Loss of interstitial cells of Cajal may be central to poor intestinal motility in diabetes mellitus

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 4, 2008, Pages 505-507

  Southwell, Bridget R ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

CELL FUNCTION; CELL REGENERATION; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE MODEL; EDITORIAL; GASTROINTESTINAL DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; INTERSTITIAL CELL OF CAJAL; INTESTINAL DYSMOTILITY; INTESTINE MOTILITY; MOTONEURON; MUSCLE CONTRACTION; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RODENT; SMOOTH MUSCLE; STOMACH EMPTYING;

EID: 41849109126     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05363.x     Document Type: Editorial

References (16)

1. Jung HK, Kim DY, Moon IH, Hong YS. Colonic transit time in diabetic patients - comparison with healthy subjects and the effect of autonomic neuropathy. Yonsei Med. J. 2003 44 : 265 72.
2. Stacher G. Diabetes mellitus and the stomach. Diabetologia 2001 44 : 1080 93.
3. Young HM, Ciampoli D, Southwell BR, Newgreen DF. Origin of interstitial cells of Cajal in the mouse intestine. Dev. Biol. 1996 180 : 97 107.
4. Sanders KM. Interstitial cells of Cajal at the clinical and scientific interface. J. Physiol. 2006 576 : 683 7.
5. Streutker CJ, Huizinga JD, Driman DK, Riddell RH. Interstitial cells of Cajal in health and disease. Part I: normal ICC structure and function with associated motility disorders. Histopathology 2007 50 : 176 89.
6. Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of interstitial cells of Cajal in motility disorders of the bowel. Am. J. Gastroenterol. 2003 98 : 618 24.
7. He CL, Soffer EE, Ferris CD, Walsh RM, Szurszewski JH, Farrugia G. Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes. Gastroenterology 2001 121 : 427 34.
8. Nakahara M, Isozaki K, Hirota S et al. Deficiency of KIT-positive cells in the colon of patients with diabetes mellitus. J. Gastroenterol. Hepatol. 2002 17 : 666 70.
9. Forster J, Damjanov I, Lin Z, Sarosiek I, Wetzel P, McCallum RW. Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings. J. Gastrointest. Surg. 2005 9 : 102 8.
10. Sanders KM, Ordog T, Ward SM. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am. J. Physiol. Gastrointest. Liver Physiol. 2002 282 : G747 56.
11. Horvath VJ, Vittal H, Ordog T. Reduced insulin and IGF-I signaling, not hyperglycemia, underlies the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach. Diabetes 2005 54 : 1528 33.
12. Horvath VJ, Vittal H, Lorincz A et al. Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis. Gastroenterology 2006 130 : 759 70.
13. Yamamoto T, Watabe K, Nakahara M et al. Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice. J. Gastroenterol. Hepatol. 2008 23 : 660 7.
14. Morton NM, Emilsson V, Liu YL, Cawthorne MA. Leptin action in intestinal cells. J. Biol. Chem. 1998 273 : 26 94 201.
15. Faussone-Pellegrini MS, Vannucchi MG, Ledder O, Huang TY, Hanani M. Plasticity of interstitial cells of Cajal: a study of mouse colon. Cell Tissue Res. 2006 325 : 211 17.
16. Mei F, Yu B, Ma H, Zhang HJ, Zhou DS. Interstitial cells of Cajal could regenerate and restore their normal distribution after disrupted by intestinal transection and anastomosis in the adult guinea pigs. Virchows Arch. 2006 449 : 348 57.