Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness

Journal of Clinical Investigation

Volumn 118, Issue 4, 2008, Pages 1437-1449

  Hayward, Lawrence J ^a   Kim, Joanna S ^b   Lee, Ming Yang ^a,f   Zhou, Hongru ^a   Kim, Ji W ^b   Misra, Kumudini ^a   Salajegheh, Mohammad ^a   Wu, Fen Fen ^c   Matsuda, Chie ^b   Reid, Valerie ^b   Cros, Didier ^b   Hoffman, Eric P ^d   Renaud, Jean Marc ^e   Cannon, Stephen C ^c   Brown Jr , Robert H ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^e UNIVERSITY OF OTTAWA   (Canada)

^f NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); OUABAIN; POTASSIUM; SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROMYOGRAPHY; EXERCISE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; MISSENSE MUTATION; MOUSE; MUSCLE FATIGUE; MUSCLE TWITCH; MUSCLE WEAKNESS; MYOTONIA; NONHUMAN; PERIODIC PARALYSIS; PHENOTYPE; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; WESTERN BLOTTING;

AGING; ANIMALS; DISEASE PROGRESSION; ELECTROPHYSIOLOGY; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUTATION; MYOTONIA; OXIDATION-REDUCTION; PARALYSIS, HYPERKALEMIC PERIODIC; PHENOTYPE; POTASSIUM; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; SODIUM CHANNELS;

EID: 41849099298     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32638     Document Type: Article

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