Inhibition of neuronal nitric oxide synthase prevents iron-induced cerebellar Purkinje cell loss in the rat

Acta Neurobiologiae Experimentalis

Volumn 68, Issue 1, 2008, Pages 26-31

  Gulturk, Sefa ^a   Kozan, Ramazan ^b   Bostanci, M Omer ^c   Sefil, Fatih ^c   Bagirici, Faruk ^c  

^a CUMHURIYET UNIVERSITY   (Turkey)

^b MUSTAFA KEMAL UNIVERSITY   (Turkey)

^c ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Iron; Neurotoxicity; Nitric oxide; Purkinje cell; Stereology

Indexed keywords

7 NITROINDAZOLE; ARGININE; FERRIC CHLORIDE; IRON; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; HISTOPATHOLOGY; IRON METABOLISM; MALE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; PURKINJE CELL; RAT; STEREOLOGY;

ANIMALS; ARGININE; CELL DEATH; CEREBELLUM; DRUG INTERACTIONS; ENZYME INHIBITORS; INDAZOLES; IRON; MALE; NEURAL INHIBITION; NITRIC OXIDE SYNTHASE TYPE I; PURKINJE CELLS; RATS; RATS, WISTAR; TRACE ELEMENTS;

EID: 41749105607     PISSN: 00651400     EISSN: 00651400     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Bagirici F, Genc H, Tan F, Demir S (2001) Neuroprotective effect of nicardipine on cadmium-induced Purkinje cell death in rat cerebellum. Neurosci Res Commun 29: 99-105.
2. Bishop G, Robinson S (2001) Quantitative analysis of cell death and ferritin expression in response to cortical iron, implications for hypoxia-ischemia and stroke. Brain Res 907: 175-187.
3. Blomgren K, Hagberg H (2006) Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med 40: 388-397.
4. Bonthius DJ, Bonthius NE, Napper RM, Astley SJ, Clarren SK, West JR (1996) Purkinje cell deficits in nonhuman primates following weekly exposure to ethanol during gestation. Teratology 53: 230-236.
5. Brown GC, Bal-Price A (2003) Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 27: 325-355.
6. Chen WJ, Edwards RB, Romero RD, Parnell S.E, Monk RJ (2003) Long-term nicotine exposure reduces Purkinje cell number in the adult rat cerebellar vermis. Neurotoxicol and Teratol 3: 329-334.
7. Ciani E, Virgili M, Contestabile A (2002) Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones. J Neurochem 81: 218-228.
8. Dawson VL, Dawson TM (1995) Physiological and toxicological actions of nitric oxide in the central nervous system. Adv Pharmacol 34: 323-342.
9. Gonzalez-Polo RA, Soler G, Rodriguezmartin A, Moran JM, Fuentes JM (2004) Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants. Cell Biol Int 28: 373-380.
10. Gundersen HJ (1977) Notes on the estimation of the numerical density of arbitrary profiles: the edge effect. J Microsc 111: 219-223.
11. Gundersen HJ (1986) Stereology of arbitrary particles. A review of unbiased number and size estimator and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143: 3-45.
12. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sorensen FB, Vesterby A (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96: 379-394.
13. Iadecola C (1997) Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20: 132-139.
14. Marangoz C, Bagirici F (2001) Effects of L-arginine on penicillin-induced epileptiform activity in rats. Jpn J Pharmacol 86: 297-301.
15. Moos T (2002) Brain iron homeostasis. Dan Med Bull 49: 279-301.
16. Reif DW, Simmons RD (1990) Nitric oxide mediates iron release from ferritin. Arch Biochem Biophys 283: 537-541.
17. Schulz JB, Matthews RT, Jenkins BG, Ferrante RJ, Siwek D, Henshaw DR, Cipolloni PB, Mecocci P, Kowall NW, Rosen BR, Beal MF (1995) Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J Neurosci 15: 8419-8429.
18. Shi HP, Most D, Efron DT, Witte MB, Barbul A (2003) Supplemental L-Arg enhances wound healing in diabetic rats. Wound Repair Regen 11: 198-203.
19. Welsh JP, Yuen G, Placantonakis DG, Vu TQ, Haiss F, O'Hearn E, Molliver ME, Aicher SA (2002) Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. Adv Neurol 89: 331-359.
20. Willmore LJ, Hiramatsu M, Kochi H, Mori A (1983) Formation of superoxide radicals after FeC13 injection into rat isocortex. Brain Res 277: 393-396.
21. Yoshida T, Limmroth V, Irikura K, Moskowitz MA (1994) The NOS inhibitor, 7-nitroindazole, decreases focal infarct volume but not the response to topical acetylcholine in pial vessels. J Cereb Blood Flow Metab 14: 924-929.
22. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5: 863-873.
23. Zhu C; Wang X, Xu F, Bahr BA, Shibata M, Uchiyama Y, Hagberg H, Blomgren K (2005) The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia- ischemia. Cell Death Differ 12: 162-176.
24. Zieminska E and Lazarewicz JW (2006) Excitotoxic neuronal injury in chronic homocysteine neurotoxicity studied in vitro: The role of NMDA and group I metabotropic glutamate receptors. Acta Neurobiol Exp (Wars) 66: 301-309.