Immunohistochemical assessment of CD25 is equally sensitive and diagnostic in mastocytosis compared to flow cytometry

European Journal of Clinical Investigation

Volumn 38, Issue 5, 2008, Pages 326-335

  Baumgartner, C ^a   Sonneck, K ^a   Krauth, M T ^a   Kneidinger, M ^a   Fodinger M ^a   Hauswirth, A W ^a   Mullauer L ^a   Valent, P ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

CD2; CD25; Diagnostic test; Mastocytosis; SM criteria

Indexed keywords

CD2 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DIAGNOSTIC TEST; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; MAST CELL; PRIORITY JOURNAL; SYSTEMIC MASTOCYTOSIS;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD; BONE MARROW; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; MASTOCYTOSIS, SYSTEMIC; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL;

EID: 41749098342     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.01942.x     Document Type: Article

References (22)

1. Lennert K, Parwaresch MR. Mast cells and mast cell neoplasia: a review. Histopathology 1979 3 : 349 65.
2. Metcalfe DD. Classification and diagnosis of mastocytosis: current status. J Invest Dermatol 1991 96 : 2 4.
3. Valent P. Biology, classification and treatment of human mastocytosis. Wien Klin Wochenschr 1996 108 : 385 97.
4. Horny H-P, Parwaresch MR, Lennert K. Bone marrow findings in systemic mastocytosis. Hum Pathol 1985 16 : 808 14.
5. Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 2001 25 : 603 25.
6. Valent P, Horny H-P, Li CY, Longley JB, Metcalfe DD, Parwaresch RM et al., Mast cell disease. World Health Organization (WHO) Classification of Tumours. Pathology & Genetics. In : Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Tumours of Haematopoietic and Lymphoid Tissues. IARC Press, Lyon 2001 pp. 291 302.
7. Escribano L, Orfao A, Díaz-Agustin B, Villarrubia J, Cerveró C, López A et al. Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications. Blood 1998 91 : 2731 6.
8. Escribano L, Díaz-Agustín B, Bellas C, Navalón R, Nuñez R, Sperr WR et al. Utility of flow cytometric analysis of mast cells in the diagnosis and classification of adult mastocytosis. Leuk Res 2001 25 : 563 70.
9. Escribano L, Diaz-Agustin B, López A, Núñez López R, García-Montero A, Almeida J et al. Immunophenotypic analysis of mast cells in mastocytosis: When and how to do it. Proposals of the Spanish Network on Mastocytosis (REMA). Cytometry B Clin Cytom 2004 58 : 1 8.
10. Sotlar K, Horny HP, Simonitsch I, Krokowski M, Aichberger KJ, Mayerhofer M et al. CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens. Am J Surg Pathol 2004 28 : 1319 25.
11. Krokowski M, Sotlar K, Krauth MT, Födinger M, Valent P, Horny HP. Delineation of patterns of bone marrow mast cell infiltration in systemic mastocytosis: value of CD25, correlation with subvariants of the disease, and separation from mast cell hyperplasia. Am J Clin Pathol 2005 124 : 560 8.
12. Florian S, Krauth MT, Simonitsch-Klupp I, Sperr WR, Fritsche-Polanz R, Sonneck K et al. Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes. Int Arch Allergy Immunol 2005 136 : 273 80.
13. Horny HP, Sotlar K, Stellmacher F, Valent P, Grabbe J. An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL). J Clin Pathol 2006 59 : 264 8.
14. Sperr WR, Escribano L, Jordan JH, Schernthaner GH, Kundi M, Horny HP, Valent P. Morphologic properties of neoplastic mast cells. delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res 2001 25 : 529 36.
15. Valent P, Samorapoompichit P, Sperr WR, Horny HP, Lechner K. Myelomastocytic leukemia: myeloid neoplasm characterized by partial differentiation of mast cell-lineage cells. Hematol J 2002 3 : 90 4.
16. Horny HP, Sillaber C, Menke D, Kaiserling E, Wehrmann M, Stehberger B et al. Diagnostic value of immunostaining for tryptase in patients with mastocytosis. Am J Surg Pathol 1998 22 : 1132 40.
17. Fritsche-Polanz R, Jordan JH, Feix A, Sperr WR, Sunder-Plassmann G, Valent P et al. Mutation analysis of c-kit in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis. Br J Haematol 2001 113 : 357 64.
18. Butterfield JH, Weiler D, Dewald G, Gleich GJ. Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk Res 1988 12 : 345 55.
19. Furitsu T, Tsujimura T, Tono T, Ikeda H, Kitayama H, Koshimizu U et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1993 92 : 1736 44.
20. Valent P, Akin C, Escribano L, Födinger M, Hartmann K, Brockow K et al. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest 2007 37 : 435 53.
21. Jordan JH, Walchshofer S, Jurecka W, Mosberger I, Sperr WR, Wolff K et al. Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: evidence for expression of CD2, CD117/Kit, and bcl-x (L). Hum Pathol 2001 32 : 545 52.
22. Valent P, Ghannadan M, Akin C, Krauth MT, Selzer E, Mayerhofer M et al. On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts. Eur J Clin Invest 2004 34 : 41 52.