Second-trimester maternal serum alpha-fetoprotein elevation and its association with adverse maternal/fetal outcome: Ten years experience

Acta Biomedica de l'Ateneo Parmense

Volumn 78, Issue 3, 2007, Pages 214-219

  Anfuso, Salvatore ^a   Soncini, Emanuele ^a   Bonelli, Patrizia ^b   Piantelli, Giovanni ^a   Gramellini, Dandolo ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b Parma Hospital   (Italy)

Author keywords

Alpha fetoprotein; Morbidity; Outcome; Perinatal; Pregnancy; Screening

Indexed keywords

ALPHA FETOPROTEIN;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ADVERSE OUTCOME; APGAR SCORE; ARTICLE; CHROMOSOME DISORDER; COHORT ANALYSIS; CONTROLLED STUDY; FETUS MALFORMATION; FETUS OUTCOME; HUMAN; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MATERNAL SERUM; NEURAL TUBE DEFECT; NEWBORN INTENSIVE CARE; PREGNANCY OUTCOME; PROTEIN BLOOD LEVEL; SECOND TRIMESTER PREGNANCY; SPONTANEOUS ABORTION; COMPARATIVE STUDY; CONGENITAL DISORDER; EVALUATION; FEMALE; ITALY; MALE; NEWBORN; PREGNANCY; PREGNANCY COMPLICATION; RETROSPECTIVE STUDY; RISK FACTOR; STATISTICAL ANALYSIS;

ADULT; ALPHA-FETOPROTEINS; APGAR SCORE; COHORT STUDIES; CONGENITAL ABNORMALITIES; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; ITALY; MALE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PREGNANCY TRIMESTER, SECOND; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 41749086486     PISSN: 03924203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Katz VL, Chescheir NC, Cefalo RC. Unexplained elevations of maternal serum alpha-fetoprotein. Obstetrical and Gynecological Survey 1990; 45: 719-26.
2. Simpson JL, Palomaki GE, Mercer B et al. Associations between adverse perinatal outcome and serially obtained second-and third-trimester maternal serum α-fetoprotein measurements. Am J Obstet Gynecol 1995; 173: 1742-48.
3. Committee on Obstetrics. Hypertension in pregnancy. Washington, DC: American College of Obstetricians and Gynecologist Technical Bulletin No. 219. American College of Obstetricians and Gynecologist, 1996.
4. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzyme levels, and low platelets): much ado about nothing? Am J Obstet Gynecol 1990; 162: 311-6.
5. American College of Obstetricians and Gynecologist. Intrauterine growth restriction. ACOG practice bulletin no. 12. Washington, DC: American College of Obstetricians and Gynecologist, 2000.
6. Bertino E, Murru P, Bagna R, et al. Standard antropometrici neonatali dell'Italia Nord-Occidentale. IJP 1999; 25; 5: 899-906.
7. Waller DK, Lusting LS, Cunningham GC, Golbus MS, Hook EB. Second-trimester maternal serum alpha-fetoprotein levels and the risk of subsequent fetal death. N Engl J Med 1991; 325: 6-10.
8. Krause TG, Christens P, Wohlfahrt J, et al. Second- trimester maternal serum alpha-fetoprotein and risk of adverse pregnancy. Obstet Gynecol 2001; 97: 277-82.
9. Simpson JL, Elias S, Morgan CD, et al. Does unexplained second-trimester (15 to 20 weeks' gestation) maternal serum α-fetoprotein elevation presage adverse perinatal outcome? Am J Obstet Gynecol 1991; 164: 829-36.
10. Cardonick EH, Bombard AT, Gross SM, et al. Unexplained increased maternal serum alpha-fetoprotein: the value of multiple marker analysis trending in predicting adverse pregnancy outcome. Proceeding of annual Society of Perinatal Obstetricians meeting. Kamuela, HI. Am J Obstet Gynecol 174: 436 (A457).
11. Chung JE, Cho JS, Han SS, Park YW, Kim JW. Uterine artery Doppler velocimetry in the prediction of adverse outcomes in unexplained MSAFP elevations. Yonsei Med J 2000; 41 (1): 17-21.
12. Ramus RM, Martin L, Dowd T, et al. Elevated maternal serum alpha-fetoprotein and placental sonolucencies. Am J Obstet Gynecol 1996; 174: 423.
13. Salafia CM, Silberman C, Herrerra NE, Mahoney MJ. Placental pathology at term associated with elevated midtrimester maternal serum AFP concentration. Am J Obstet Gynecol 1988; 158: 1064-6.
14. Yaron Y, Cherry M, Kramer RL, et al. Second trimester maternal serum marker screening: maternal serum α-fetoprotein, β-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome. Am J Obstet Gynecol 1999; 181: 968-74.
15. Purdie DW, Young JL, Guthrie KA, Picton CE. Fetal growth achievement and elevated maternal serum alpha-fetoprotein. Br J Obstet Gynaecol 1983; 90: 433-6.
16. Dyer SN, Burton BK, Nelson LH. Elevated maternal serum alpha-fetoprotein levels and oligohydramnios: poor prognosis for pregnancy outcome. Am J Obstet Gynecol 1987; 157: 336-9.
17. Nelson LH, Bensen J, Burton BK. Outcomes in patients with unusually high maternal serum alpha-fetoprotein levels. Am J Obstet Gynecol 1987; 157: 572-6
18. Huerta-Enochian G, Katz V, Erfuth S. The association of abnormal alpha-fetoprotein and adverse pregnancy outcome: does increased fetal surveillance affect pregnancy outcome? Am J Obstet Gynecol 2001; 184 (7): 1549-53; discussion 1553-5.