Synthesis and biological activity of new tricyclic purine derivatives obtained by intramolecular N-7 alkylation

Letters in Drug Design and Discovery

Volumn 5, Issue 2, 2008, Pages 122-126

  Carmo, Arturene Maria Lino ^a   Braga, Fernanda Gambogi ^a   De Paula, Marcio Luiz ^a   Ferreira, Ana Paula ^a   Teixeira, Henrique Couto ^a   Da Silva, Adilson David ^a   Coimbra, Elaine Soares ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Anticancer; Antileishmania; NO production; Purine analogues

Indexed keywords

6 (3' CHLOROPROPYLTHIO)PURINE; 7,8 DIHYDRO [1,4]THIAZEPINO[3,24 HI]PURINE HYDROFLUORIDE; 7,8 DIHYDRO[1,4]THIAZINO[3,2,4 HI]PURINE; 8,9 DIHYDRO 7H[1,4]THIAZEPINO[3,2,4 HI]PURINE; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; BCG VACCINE; DOCETAXEL; NITRIC OXIDE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN KB; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PURIFICATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEISHMANIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA CHAGASI; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; MACROPHAGE; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 41649121266     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018008783928535     Document Type: Article

References (25)

1. Rida, S.M.; Ashour, F.A.; El-Hawash, S.A.M; El-Semary, M.M.; Badr, M.H. Arch. Pharm. Chem., 2007, 340, 185.
2. Lech-Maranda, E.; Korycka, A.; Robak, T. Mini. Rev. Med. Chem., 2006, 6, 575.
3. Steurer, M.; Pall, G.; Richards, S.; Schwarzer, G.; Bohlius, J.; Greil, R. Cancer Treat. Rev., 2006, 32, 377.
4. Zaza, G.; Yang, W.; Kager, L.; Cheok, M.; Downing, J.; Pui, C.H.; Cheng, C.; Relling, M.V.; Evans, W.E. Blood, 2004, 104, 1435.
5. Robak, T.; Lech-Maranda, E.; Korycka, A.; Robak, E. Curr. Med. Chem., 2006, 13, 3165.
6. Da Silva, A.D.; Machado, A.S.; Tempête, C.; Robert-Gero, M. Eur. J. Med. Chem., 1994, 29, 149.
7. Braga, F.G.; Coimbra, E.S.; Matos, M.O., Carmo A.M.L.; Cancio, M.D.; Da Silva, A.D. Eur. J. Med. Chem., 2007, 42, 530.
8. Braga, F.G.; Bouzada, M.L.M.; Fabri, R.L.; Matos, M.O.; Moreira, F.O.; Scio, E.; Coimbra, E.S. J. Ethnopharmacol., 2007, 111, 396.
9. Delorenzi, J.C.; Freire-de-Lima, L.; Gattass, C.R.; Costa, D.A.; He, L.; Kuehne, M.E.; Saraiva, E.M.B. Antimicrob. Agents Chemother., 2002, 46, 2111.
10. Larabi, M.; Yardley, V.; Loiseau, P.M.; Appel, M.; Legrand, P.; Gulik, A.; Bories, C.; Croft, S.L.; Barratti, G. Antimicrob. Agents Chemother., 2003, 47, 3774.
11. Green, S.J.; Crawford, R.M.; Hockmeyer, J.T.; Meltzer, M.S.; Nacy, C.A. J. Immunol., 1990, 145, 4290.
12. Napolitano, D.R.; Mineo, J.R.; Souza, M.A.; Paula, J.E.; Espíndola, L.S.; Espíndola, F.S. J. Ethnopharmacol., 2005, 99, 37.
13. Parker, W.B.; Secrist, J.A.3rd.; Waud, W.R. Curr. Opin. Investig. Drugs, 2004, 5, 592.
14. Landfear, S.M. Curr. Opin. Microbiol., 2000, 3, 417.
15. Murray, H.W.; Berman, J.D.; Davies, C.R.; Saravia, N.G. Lancet, 2005, 366, 1561.
16. Grimaldi Jr, G.; Tesh, R.B. Clin. Microbiol. Rev., 1993, 6, 230.
17. Escobar, P.; Matu, S.; Marques, C.; Croft, S.L. Acta Tropica, 2002, 81, 151.
18. Tempone, A.G.; Borborema, S.E.; de Andrade, H.F.Jr.; de Amorim, N.C.G.; Yogi, A.; Carvalho, C.S.; Bachiega, D.; Lupo, F.N.; Bonotto, S.V.; Fischer, D.C. Phytomedicine, 2005, 12, 382.
19. Al-Salabi, M.I.; Wallace, L.J.M.; Koning, H.P. Mol. Pharmacol., 2003, 63, 814.
20. Landfear, S.M.; Ullman, B.; Carter, N.S.; Sanchez, M.A. Eukaryot. Cell, 2004, 3, 245.
21. Al-Salabi, M.I.; Koning, H.P. Antimicrob. Agents Chemother., 2005, 49, 3682.
22. Chan, J.; Xing, Y.; Magliozzo, R.S.; Bloom, B.R. J. Exp. Med., 1992, 175, 1111.
23. Brunet, L.R. Int. Immunopharmacol., 2001, 1, 1457.
24. Peteroy-Kelly, M.; Venketaraman, V.; Connell, N. Infect. Immun., 2001, 60, 5823.
25. Conner, E.M.; Grisham, M.B. Nutrition, 1996, 12, 274.