Bull's eye missed by the magic bullet: Preclinical investigations, publication bias, and promising new interventions

Critical Care Medicine

Volumn 36, Issue 4, 2008, Pages 1361-1363

  Tenhunen, Jyrki J ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Cytokines; Ethyl pyruvate; Lipopolysaccharide; Mice; Mortality; Nuclear factor B; Sepsis

Indexed keywords

CYTOKINE; ETHYLPYRUVATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PYRUVATE SODIUM; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

CLINICAL TRIAL; DNA BINDING; EDITORIAL; ESTERIFICATION; HUMAN; INCIDENCE; INFLAMMATION; ISCHEMIA; MORTALITY; PERITONITIS; PRIORITY JOURNAL; PUBLISHING; REPERFUSION INJURY; SEPSIS; SINGLE DRUG DOSE;

EID: 41649112624     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31816a1414     Document Type: Editorial

References (12)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
2. Alberti C, Brun-Buisson C, Burchardi H, et al: Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med 2002; 28:108-121
3. Karlsson S, Varpula M, Ruokonen E, et al: Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: The Finnsepsis study. Intensive Care Med 2007; 33:435-443
4. Kim JB, Yu YM, Kim SW, et al: Antiinflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res 2005; 1060:188-192
5. Zeng J, Liu J, Yang GY, et al: Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology 2007; 107:630-640
6. Fink MP: Ethyl pyruvate: A novel antiinflammatory agent. J Intern Med 2007; 261:349-362
7. Su J, Li X, Cui X, et al: Ethyl pyruvate decreased early nuclear factor-κB levels but worsened survival in lipopolysaccharidechallenged mice. Crit Care Med 2008; 36:1059-1067
8. Tripepi G, Jager KJ, Dekker FW, et al: Bias in clinical research. Kidney Int 2008; 73:148-153
9. Macleod MR, O'Collins T, Howells DW, et al: Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 2004; 35:1203-1208
10. Hauser B, Kick J, Asfar P, et al: Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. Crit Care Med 2005; 33:2034-2042
11. Tenhunen JJ, Fink MP, Ruokonen E, et al: Fluid resuscitation with ethyl pyruvate solution restores splanchnic perfusion better than Ringer's acetate alone. Crit Care Med 2004; 32:A23
12. Hiltebrand LB, Krejci V, Jakob SM, et al: Effects of vasopressin on microcirculatory blood flow in the gastrointestinal tract in anesthetized pigs in septic shock. Anesthesiology 2007; 106:1156-1167