Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes

Journal of Medicinal Chemistry

Volumn 51, Issue 5, 2008, Pages 1309-1318

  Scaglione, Jamie B ^a   Jastrzebska, Izabella ^a   Krishnan, Kathiresan ^a   Li, Ping ^a   Akk, Gustav ^a   Manion, Brad D ^a   Benz, Ann ^a   Taylor, Amanda ^a   Rath, Nigam P ^b   Evers, Alex S ^a   Zorumski, Charles F ^a   Mennerick, Steven ^a   Covey, Douglas F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; CYCLOPENTA[BETA]ANTHRACENE; CYCLOPENTA[BETA]PHENANTHRENE; DODECAHYDRO 3A METHYL SPIRO [3H BENZ[E]INDENE 3,2' OXIRANE] 7 ETHANOL; DODECAHYDRO 8 HYDROXY 7A METHYL 1H CYCLOPENTAL[BETA]PHENANTHRENE 3,8(2H,4H)DIONE; DODECAHYDRO 9A METHYL SPIRO [1H BENZ[F]INDENE 1,2' OXIRANE] 6 ETHANOL; HEXADECAHYDRO 3 HYDROXY 7A METHYL 8H CYCLOPENTAL[BETA]PHENANTHREN 8 ONE; HEXADECAHYDRO 7A METHYLSPIRO [8H CYCLOPENTAL(BETA)PHENANTHRENE 8,2 OXIRAN] 3 OL; HEXADECAHYDRO 8 HYDROXY 7A METHYL 3H CYCLOPENTAL[BETA]PHENANTHREN 3 ONE; HEXADODECAHYDRO 1 HYDROXY 11A METHYL 7H CYCLOPENTA[BETA]ANTHRACEN 7 ONE; HEXADODECAHYDRO 11A METHYL SPIRO[1H CYCLOPENTA(BETA)ANTHRACENE 1,2' OXIRAN] 7 OL; HEXADODECAHYDRO 7 HYDROXY 11A METHYL 1H CYCLOPENTA[BETA]ANTHRACEN 1 ONE; NEUROSTEROID; STEROID; TETRADECAHYDRO 11A METHYL 1H CYCLOPENTA[BETA]ANTHRACENE 1,7 (4H)DIONE; UNCLASSIFIED DRUG;

ANESTHESIA; ARTICLE; BINDING SITE; DRUG MECHANISM; GENE MUTATION; HYDROGEN BOND; HYDROPHOBICITY; PHARMACOPHORE; PROTEIN INTERACTION; RING OPENING;

ANESTHETICS; ANIMALS; ANTHRACENES; BINDING SITES; BRAIN; CELL LINE; GABA MODULATORS; HUMANS; LARVA; MODELS, MOLECULAR; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PHENANTHRENES; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; STEREOISOMERISM; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 41649107803     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701128r     Document Type: Article

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