Identification of two neutralization epitopes on the capsid protein of avian hepatitis E virus

Journal of General Virology

Volumn 89, Issue 2, 2008, Pages 500-508

  Zhou, E M ^a   Guo, Hailong ^b,d   Huang, F F ^c   Sun, Z F ^c   Meng, X J ^c  

^a SHANDONG AGRICULTURAL UNIVERSITY   (China)

^b IOWA STATE UNIVERSITY   (United States)

^c CENTER FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASES   (United States)

^d BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; EPITOPE; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; VIRUS ANTIGEN; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVIAN HEPATITIS E VIRUS; CHICKEN; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HEPATITIS E VIRUS; IN VITRO STUDY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; VIREMIA; VIRUS PARTICLE; VIRUS SHEDDING; WESTERN BLOTTING; ANIMAL; ANIMAL HEPATITIS; CHEMISTRY; GENETICS; HEPEVIRUS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; VIROLOGY; VIRUS CAPSID;

AVES; AVIAN HEPATITIS E VIRUS; GALLUS GALLUS; MIRIDAE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CAPSID; CHICKENS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HEPATITIS, VIRAL, ANIMAL; HEPEVIRUS;

EID: 41649103348     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83366-0     Document Type: Article

References (41)

1. Amon, J. J., Drobeniuc, J., Bower, W. A., Magana, J. C., Escobedo, M. Á., Williams, I. T., Bell, B. P. & Armstrong, G. L. (2006). Locally acquired hepatitis E virus infection, El Paso, Texas. J Med Virol 78, 741-746.
2. Baccala, R., Quang, T. V., Gilbert, M., Ternynck, T. & Avrameas, S. (1989). Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc Natl Acad Sci U S A 86, 4624-4628.
3. Billam, P., Huang, F. F., Sun, Z. F., Pierson, F. W., Duncan, R. B., Elvinger, F., Guenette, D. K., Toth, T. E. & Meng, X. J. (2005). Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens. J Virol 79, 3429-3437.
4. Bryan, J. P., Tsarev, S. A., Iqbal, M., Ticehurst, J., Emerson, S., Ahmed, A., Duncan, J., Rafiqui, A. R., Malik, I. A. & Purcell, R. H. (1994). Epidemic hepatitis E in Pakistan: patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease. J Infect Dis 170, 517-521.
5. Emerson, S. U. & Purcell, R. H. (2001). Recombinant vaccines for hepatitis E. Trends Mol Med 7, 462-466.
6. Emerson, S. U. & Purcell, R. H. (2003). Hepatitis E virus. Rev Med Virol 13, 145-154.
7. Emerson, S. U., Anderson, D., Arankalle, A., Meng, X. J., Purdy, M., Schlauder, G. G. & Tsarev, S. A. (2004). Hepevirus. In Virus Taxonomy, Eighth Report of the International Committee on Taxonomy of Viruses, pp. 851-855. Edited by C. M. Fauquet, M. A. Mayo, J. Maniloff, U. Desselberger & L. A. Ball. London: Elsevier Academic Press.
8. Emerson, S. U., Clemente-Casares, P., Moiduddin, N., Arankalle, V. A., Torian, U. & Purcell, R. H. (2006). Putative neutralization epitopes and broad cross-genotype neutralization of Hepatitis E virus confirmed by a quantitative cell-culture assay. J Gen Virol 87, 697-704.
9. Guo, H., Zhou, E. M., Sun, Z. F., Meng, X. J. & Halbur, P. G. (2006). Identification of B-cell epitopes in the capsid protein of avian hepatitis E virus (avian HEV) that are common to human and swine HEVs or unique to avian HEV. J Gen Virol 87, 217-223.
10. Guo, H., Zhou, E. M., Sun, Z. F. & Meng, X. J. (2007a). Egg whites from eggs of chickens infected experimentally with avian hepatitis E virus contain infectious virus, but evidence of complete vertical transmission is lacking. J Gen Virol 88, 1532-1537.
11. Guo, H., Zhou, E. M., Sun, Z. F. & Meng, X. J. (2007b). Protection of chickens against avian hepatitis E virus (avian HEV) infection by immunization with recombinant avian HEV capsid protein. Vaccine 25, 2892-2899.
12. Haqshenas, G., Shivaprasad, H. L., Woolcock P. R., Read, D. H. & Meng, X. J. (2001). Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States. J Gen Virol 82, 2449-2462.
13. Haqshenas, G., Huang, F. F., Fenaux, M., Guenette, D. K., Plerson, F. W., Larsen, C. T., Shivaprasad, H. L., Toth, T. E. & Meng, X. J. (2002). The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and chicken big liver and spleen disease virus. J Gen Virol 83, 2201-2209.
14. Huang, F. F., Sun, Z. F., Emerson, S. U., Purcell, R. H., Shivaprasad, H. L., Pierson, F. W., Toth, T. E. & Meng, X. J. (2004). Determination and analysis of the complete genomic sequence of avian hepatitis E virus (avian HEV) and attempts to infect rhesus monkeys with avian HEV. J Gen Virol 85, 1609-1618.
15. Huang, F. F., Pierson, F. W., Toth, T. E. & Meng, X. J. (2005). Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV. J Gen Virol 86, 2585-2593.
16. Im, S. W., Zhang, J. Z., Zhuang, H., Che, X. Y., Zhu, W. F., Xu, G. M., Li, K., Xia, N. S. & Ng, M. H. (2001). A bacterially expressed peptide prevents experimental infection of primates by the hepatitis E virus. Vaccine 19, 3726-3732.
17. Konishi, E. (1997). Monoclonal antibodies multireactive with parasite antigens produced by hybridomas generated from naive mice. Parasitology 115, 387-393.
18. Li, C., Candotti, D. & Allain, J. P. (2001). Production and characterization of monoclonal antibodies specific for a conserved epitope within hepatitis C virus hypervariable region 1. J Virol 75, 12412-12420.
19. Li, T. C., Suzaki, Y., Ami, Y., Dhole, T. N., Miyamura, T. & Takeda, N. (2004). Protection of cynomolgus monkeys against HEV infection by oral administration of recombinant hepatitis E virus-like particles. Vaccine 22, 370-377.
20. Li, S. W., Zhang, J., Li, Y. M., Ou, S. H., Huang, G. Y., He, Z. O., Ge, S. X., Xian, Y. L., Pang, S. O. & other authors (2005). A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine 23, 2893-2901.
21. Mansuy, J. M., Peron, J. M., Abravanel, F., Poirson, H., Dubois, M., Miedouge, M., Vischi, F., Alric, L., Vinel, J. P. & other authors (2004). Hepatitis E in the south west of France in individuals who have never visited an endemic area. J Med Virol 74, 419-424.
22. Meng, X. J., Purcell, R. H., Halbur, P. G., Lehman, J. R., Webb, D. M., Tsareva, T. S., Haynes, J. S., Thacker, B. J. & Emerson, S. U. (1997). A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A 94, 9860-9865.
23. Meng, X. J., Wiseman, B., Elvinger, F., Guenette, D. K., Toth, T. E., Engle, R. E., Emerson, S. U. & Purcell, R. H. (2002). Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol 40, 117-122.
24. Mizuo, H., Yezaki, Y., Sugawara, K., Tsuda, F., Takahashi, M., Nishizawa, T. & Okamoto, H. (2005). Possible risk factors for the transmission of hepatitis E virus and for the severe form of hepatitis E acquired locally in Hokkaido, Japan. J Med Virol 76, 341-349.
25. Nawagitgul, P., Harms, P. A., Morozov, I., Thacker, B. J., Sorden, S. D., Lekcharoensuk, C. & Paul, P. S. (2002). Modified indirect porcine circovirus (PCV) type 2-based and recombinant capsid protein (ORF2)-based enzyme-linked immunosorbent assays for detection of antibodies to PCV. Clin Diagn Lab Immunol 9, 33-40.
26. Purcell, R. H., Nguyen, H., Shapiro, M., Engle, R. E., Govindarajan, S., Blackwelder, W. C., Wong, D. C., Prieels, J. P. & Emerson, S. U. (2003). Pre-clinical immunogenicity and efficacy trial of a recombinant hepatitis E vaccine. Vaccine 21, 2607-2615.
27. Purdy, M. A., McCaustland, K. A., Krawczynski, K., Spelbring, J., Reyes, G. R. & Bradley, D. W. (1993). Preliminary evidence that a trpE-HEV fusion protein protects cynomolgus macaques against challenge with wild-type hepatitis E virus (HEV). J Med Virol 41, 90-94.
28. Riddell, M. A., Li, F. & Anderson, D. A. (2000). Identification of immunodominant and conformational epitopes in the capsid protein of hepatitis E virus by using monoclonal antibodies. J Virol 74, 8011-8017.
29. Robinson, R. A., Burgess, W. H., Emerson, S. U., Leibowitz, R. S., Sosnovtseva, S. A., Tsarev, S. & Purcell, R. H. (1998). Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells. Protein Expr Purif 12, 75-84.
30. Sadler, G. J., Mells, G. F., Shah, N. H., Chesner, I. M. & Walt, R. P. (2006). UK acquired hepatitis E - an emerging problem? J Med Virol 78, 473-475.
31. Schick, M. R., Dreesman, G. R. & Kennedy, R. C. (1987). Induction of an anti-hepatitis B surface antigen response in mice by noninternal image (Ab2 alpha) anti-idiotypic antibodies. J Immunol 138, 3419-3425.
32. Schofield, D. J., Glamann, J., Emerson, S. U. & Purcell, R. H. (2000). Identification by phage display and characterization of two neutralizing chimpanzee monoclonal antibodies to the hepatitis E virus capsid protein. J Virol 74, 5548-5555.
33. Schofield, D. J., Purcell, R. H., Nguyen, H. T. & Emerson, S. U. (2003). Monoclonal antibodies that neutralize HEV recognize an antigenic site at the carboxyterminus of an ORF2 protein vaccine. Vaccine 22, 257-267.
34. Shrestha, M. P., Scott, R. M., Joshi, D. M., Mammen, M. P., Jr, Thapa, G. B., Thapa, N., Myint, K. S., Fourneau, M., Kuschner, R. A. & other authors (2007). Safety and efficacy of a recombinant hepatitis E vaccine. N Engl J Med 356, 895-903.
35. Sun, Z. F., Larsen, C. T., Huang, F. F., Billam, P., Pierson, F. W., Toth, T. E. & Meng, X. J. (2004). Generation and infectivity titration of an infectious stock of avian hepatitis E virus (HEV) in chickens and cross-species infection of turkeys with avian HEV. J Clin Microbiol 42, 2658-2662.
36. Tam, A. W., Smith, M. M. Guerra, M. E., Huang, C. C., Bradley, D. W., Fry, K. E. & Reyes, G. R. (1991). Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185, 120-131.
37. Tsarev, S. A., Tsareva, T. S., Emerson, S. U., Govindarajan, S., Shapiro, M., Gerin, J. L. & Purcell, R. H. (1994). Successful passive and active immunization of cynomolgus monkeys against hepatitis E. Proc Natl Acad Sci U S A 91, 10198-10202.
38. Zhang, M., Emerson, S. U., Nguyen, H., Engle, R. E., Govinderajan, S., Gerin, J. L. & Purcell, R. H. (2001). Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells. Vaccine 20, 853-857.
39. Zhang, J., Gu, Y., Ge, S. X., Li, S. W., He, Z. O., Huang, G. Y., Zhuang, H., Ng, M. H. & Xia, N. S. (2005). Analysis of hepatitis E virus neutralization sites using monoclonal antibodies directed against a virus capsid protein. Vaccine 23, 2881-2892.
40. Zhou, E. & Afshar, A. (1999). Characterisation of monoclonal antibodies to epizootic hemorrhagic disease virus of deer (EHDV) and bluetongue virus by immunisation of mice with EHDV recombinant VP7 antigen. Res Vet Sci 66, 247-252.
41. Zhou, Y. H., Purcell, R. H. & Emerson, S. U. (2004). An ELISA for putative neutralizing antibodies to hepatitis E virus detects antibodies to genotypes 1, 2, 3, and 4. Vaccine 22, 2578-2585.