Method for quantifying nitromethane in blood as a potential biomarker of halonitromethane exposure

Environmental Science and Technology

Volumn 42, Issue 7, 2008, Pages 2522-2527

  Alwis, K Udeni ^a   Blount, Benjamin C ^a   Silva, Lalith K ^a   Smith, Mitchell M ^a   Loose, Karl Hermann ^b  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b THERMO FISHER SCIENTIFIC   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH RESOLUTION MASS SPECTROMETRY (HRMS); LINEAR CALIBRATION CURVE;

BIOMARKERS; BLOOD; ENVIRONMENTAL IMPACT; EXTRACTION; TOXICITY;

METHANE;

BIOLOGICAL MARKER; CHLOROPICRIN; HALONITROMETHANE; ISOTOPE; METHANE; NITROMETHANE; PEROXYNITRITE; UNCLASSIFIED DRUG;

BIOMARKERS; BLOOD; ENVIRONMENTAL IMPACT; EXTRACTION; METHANE; TOXICITY;

BIOMARKER; BLOOD; GAS CHROMATOGRAPHY; GENOTOXICITY; HALOCARBON; HEALTH IMPACT; MASS SPECTROMETRY; OCCUPATIONAL EXPOSURE; ORGANIC NITROGEN COMPOUND; POLLUTION EXPOSURE; SAMPLING;

ADOLESCENT; ADULT; AGED; ANALYTIC METHOD; ARTICLE; BLOOD; BLOOD SAMPLING; CALIBRATION; CHEMICAL WARFARE; CONCENTRATION (PARAMETERS); CORRELATION COEFFICIENT; DEHALOGENATION; DIAGNOSTIC ACCURACY; DILUTION; DRUG BLOOD LEVEL; FEMALE; GAS CHROMATOGRAPHY; HEALTH; HUMAN; MALE; MASS SPECTROMETRY; POPULATION; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SOLID PHASE MICROEXTRACTION; TIME; WORK ENVIRONMENT;

BIOLOGICAL MARKERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALOGENS; HUMANS; METHANE; NITROPARAFFINS; QUALITY CONTROL;

MAMMALIA;

EID: 41649085235     PISSN: 0013936X     EISSN: None     Source Type: Journal    
DOI: 10.1021/es702733k     Document Type: Article

References (27)

1. Krasner, S. W.; Weinberg, H. S.; Richardson, S. D.; Pastor, S. J.; Chinn, R.; Sclimenti, M. J.; Onstad, G. D.; Thruston, A. D., Jr. Occurrence of a new generation of disinfection byproducts. Environ. Sci. Technol. 2006, 40, 7175-7185.
2. Hoigne, J.; Bader, H. The formation of trichloronitromethane (chloropicrin) and chloroform in a combined ozonation/chlorination treatment of drinking water. Water Res. 1988, 22, 313-319.
3. Plewa, M. J.; Wagner, E. D.; Jazwierska, P.; Richardson, S. D.; Chen, P. H.; McKague, A. B. Halonitromethane drinking water disinfection byproducts: chemical characterization and mammalian cell cytotoxicity and genotoxicity. Environ. Sci. Technol. 2004, 38, 62-68.
4. Kundu, B.; Richardson, S. D.; Granville, C. A.; Shaughnessy, D. T.; Hanley, N. M.; Swartz, P. D.; Richard, A. M.; DeMarini, D. M. Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra. Mutat. Res. 2004, 554, 335-350.
5. Kundu, B.; Richardson, S. D.; Swartz, P. D.; Matthews, P. P.; Richard, A. M.; DeMarini, D. M. Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water. Mutat. Res. 2004, 562, 39-65.
6. Sparks, S. E.; Quistad, G. B.; Casida, J. E. Chloropicrin: reactions with biological thiols and metabolism in mice. Chem. Res. Toxicol. 1997, 10, 1001-1007.
7. NTP 11th Report on Carcinogens - Nitromethane. National Toxicology Program Report on Carcinogens, 11th ed.; U.S. Department of Health and Human Services: Washington, D.C., January, 2005.
8. Webb, K. G.; Fowler, J. F., Jr. Occupational allergic contact dermatitis to nitromethane. Am. J. Contact Dermat. 2002, 13, 201-202.
9. Page, E. H.; Pajeau, A. K.; Arnold, T. C.; Fincher, A. R.; Goddard, M. J. Peripheral neuropathy in workers exposed to nitromethane. Am. J. Ind. Med. 2001, 40, 107-113.
10. Sandyk, R.; Gillman, M. A. Motor dysfunction following chronic exposure to a fluoroalkane solvent mixture containing nitromethane. Eur. Neurol. 1984, 23, 479-481.
11. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans - Nitromethane; International Agency for Research on Cancer: Lyon, France, 2000; Vol. 77.
12. NTP Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies); National Institute of Environmental Health Sciences: Research Triangle Park, NC, Feb, 1997; pp 1-289.
13. Cook, M. D.; Clark, R. F. Creatinine elevation associated with nitromethane exposure: a marker of potential methanol toxicity. J. Emerg. Med. 2007, 33, 249-253.
14. Hecht, S. S. Tobacco smoke carcinogens and breast cancer. Environ. Mol. Mutagen. 2002, 39, 119-126.
15. Blount, B. C.; Kobelski, R. J.; McElprang, D. O.; Ashley, D. L.; Morrow, J. C.; Chambers, D. M.; Cardinali, F. L. Quantification of 31 volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. B 2006, 832, 292-301.
16. Ashley, D. L.; Bonin, M. A.; Cardinali, F. L.; McCraw, J. M.; Holler, J. S.; Needham, L. L.; Patterson, D. G., Jr. Determining volatile organic compounds in human blood from a large sample population by using purge and trap gas chromatography/mass spectrometry. Anal. Chem. 1992, 64, 1021-1029.
17. Silva, L. K.; Bonin, M. A.; McKague, B.; Blount, B. C. Quantification of dichloroiodomethane and bromochloroiodomethane in human blood by solid-phase microextraction coupled with gas chromatography-high-resolution mass spectrometry. J. Anal. Toxicol. 2006, 30, 670-678.
18. Colby, B. N.; McCaman, M. W. A comparison of calculation procedures for isotope dilution determinations using gas chromatography mass spectrometry. Biomed. Mass Spectrom. 1979, 6, 225-30.
19. Taylor, J. K. Quality Assurance of Chemical Measurements. Lewis Publishers: Chelsea, MI, 1987.
20. Sparks, S. E.; Quistad, G. B.; Li, W.; Casida, J. E. Chloropicrin dechlorination in relation to toxic action. J. Biochem. Mol. Toxicol. 2000, 14, 26-32.
21. Castro, C. E.; Bartnicki, E. W. Conformational isomerism and effective redox geometry in the oxidation of heme proteins by alkyl halides, cytochrome c, and cytochrome oxidase. Biochemistry 1975, 14, 498-503.
22. Castro, C. E.; Wade, R. S.; Belser, N. Biodegradation. The metabolism of chloropicrin by Pseudomonas sp. J. Agric. Food Chem. 1983, 31, 1184-1187.
23. Castro, C. E. Biodehalogenation: The kinetics and rates of the microbial cleavage of carbon-halogen bonds. Environ. Toxicol. Chem. 1993, 12, 1609-1618.
24. Castro, C. E.; Yokohama, W. H.; Belser, N. Biodehalogenation. Reductive reactivities of microbial and mammalian cytochromes P-450 compared with heme and whole-cell models. J. Agric. Food Chem. 1988, 31, 915-919.
25. Pacher, P.; Beckman, J. S.; Liaudet, L. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 2007, 87, 315-424.
26. Yi, D.; Smythe, G. A.; Blount, B. C.; Duncan, M. W. Peroxynitrite- mediated nitration of peptides: characterization of the products by electrospray and combined gas chromatography-mass spectrometry. Arch. Biochem. Biophys. 1997, 344, 253-259.
27. Kamat, J. P. Peroxynitrite: a potent oxidizing and nitrating agent. Indian J. Exp. Biol. 2006, 44, 436-447.