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Volumn 9, Issue 8, 2008, Pages 1779-1781

A simple, efficient and green procedure for Knoevenagel reaction in [MMIm][MSO4] ionic liquid

Author keywords

Carbonyl compounds; Condensation; Ionic liquids; Knoevenagel; Malononitrile

Indexed keywords

ALDEHYDES; CATALYSTS; IONIC LIQUIDS; SOLVENTS; THERMAL EFFECTS;

EID: 41549166005     PISSN: 15667367     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.catcom.2008.02.010     Document Type: Article
Times cited : (65)

References (32)
  • 20
    • 41549095091 scopus 로고    scopus 로고
    • E. Tojo, P. Verdía, "Knoevenagel reaction in alkylsulfate ionic liquids, in: Abstracts Book, 6th ANQUE International Congress of Chemistry, Puerto de la Cruz, Tenerife, December 5-7, ANQUE, Spain, 2006, p. 279.
    • E. Tojo, P. Verdía, "Knoevenagel reaction in alkylsulfate ionic liquids, in: Abstracts Book, 6th ANQUE International Congress of Chemistry, Puerto de la Cruz, Tenerife, December 5-7, ANQUE, Spain, 2006, p. 279.
  • 21
    • 41549117658 scopus 로고    scopus 로고
    • E. Tojo, F. Santamarta, A simple, efficient and green procedure for Knoevenagel reaction, in: Proceedings of the XVIII Mendeleev Congress on General and Applied Chemistry, Moscow, September 23-28, vol. 5, 2007, p. 428.
    • E. Tojo, F. Santamarta, A simple, efficient and green procedure for Knoevenagel reaction, in: Proceedings of the XVIII Mendeleev Congress on General and Applied Chemistry, Moscow, September 23-28, vol. 5, 2007, p. 428.
  • 23
    • 41549127229 scopus 로고    scopus 로고
    • note
    • Procedure for the Knoevenagel reaction of benzaldehyde with malononitrile. A mixture of benzaldehyde (67 mg), malononitrile (1.0 eq.) and glycine (0.2 eq.) in ionic liquid (1 g) was stirred in a closed round-bottomed flask until completion of the reaction as indicated by TLC (Hexane:AcOEt = 80:20). The reaction mixture was then extracted with ethyl acetate (3 × 2 mL), and the pooled organic extract was concentrated under vacuum, affording either a pure solid (entry 4 in Table 1) or a viscous oil (entries 1-3) that was purified by column chromatography on silica gel. The ionic liquids were dried by stirring under high vacuum for 24 h before use.
  • 28
    • 41549084312 scopus 로고    scopus 로고
    • note
    • +(1 0 0).
  • 29
    • 41549143297 scopus 로고    scopus 로고
    • T.B. Posner, C.D. Hall, J.C.S. Perkin II 729 (1976).
    • T.B. Posner, C.D. Hall, J.C.S. Perkin II 729 (1976).
  • 30
    • 41549119530 scopus 로고    scopus 로고
    • note
    • 4] + glycine in the Knoevenagel reaction of benzaldehyde with malononitrile.Reaction and work-up as above (Ref. 21) afforded a solid that required no further purification. The reaction medium was recovered by evaporation of ethyl acetate and water under vacuum, and was reused.
  • 31
    • 41549099757 scopus 로고    scopus 로고
    • A. García-Lorenzo, E. Tojo, J. Tojo, M. Teijeira, F.J. Rodríguez-Berrocal, M.P. González, V.S. Martínez-Zorzano, Green Chem. (2008) in press.
    • A. García-Lorenzo, E. Tojo, J. Tojo, M. Teijeira, F.J. Rodríguez-Berrocal, M.P. González, V.S. Martínez-Zorzano, Green Chem. (2008) in press.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.