Relationship between fentanyl dosage and immune function in the postoperative period

Journal of Opioid Management

Volumn 4, Issue 1, 2008, Pages 27-33

  Yardeni, Israel Z ^a,b   Beilin, Benzion ^a,b   Mayburd, Eduard ^a,b   Alcalay, Yifat ^a,b   Bessler, Hanna ^a,b  

^a HASHARON HOSPITAL   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cytokines; Fentanyl; NK cell cytotoxicity; Surgery

Indexed keywords

ATROPINE; FENTANYL; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; ISOFLURANE; LORAZEPAM; MIDAZOLAM; NEOSTIGMINE; PROPOFOL; VECURONIUM;

ADULT; ANESTHESIA MECHANISM; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CELLULAR IMMUNITY; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; INCUBATION TEMPERATURE; INCUBATION TIME; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PERIOPERATIVE PERIOD; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SINGLE DRUG DOSE; STATISTICAL ANALYSIS;

EID: 41549143131     PISSN: 15517489     EISSN: None     Source Type: Journal    
DOI: 10.5055/jom.2008.0005     Document Type: Article

References (36)

1. Lennard TW, Shenton BK, Borzotta A, et al.: The influence of surgical operation on components of the human immune system. Br J Surg. 1985; 72: 771-776.
2. Salo M: Effects of anaesthesia and surgery on the immune response. Acta Anaesthesiol Scand. 1992; 36(3): 201-220.
3. Vallejo R, Le Leon-Casasola O, Benyamin R: Opiod therapy and immunosuppression: A review. Am J Ther. 2004; 11(5): 354-365.
4. Beilin B, Martin FC, Shavit Y, et al.: Suppression of natural killer cell activity by high-dose narcotic anesthesia in rats. Brain Behav Immunol. 1989; 3(2): 129-137.
5. Beilin B, Shavit Y, Cohn S, et al.: Narcotic-induced suppression of natural killer cell activity in ventilated rats. Clin Immunol Immunpathol. 1992; 64(2): 173-176.
6. Beilin B, Shavit Y, Hart J, et al.: Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period. Anesth Analg. 1996; 82(3): 492-497.
7. Hall GM, Young C, Holderoft A, et al.: Substrate mobilization during surgery. A comparison between halothane and fentanyl anaesthesia. Anaesthesia. 1978; 33: 924-930.
8. Tonnesen E, Brinklov MM, Christensen NJ, et al.: Natural killer cell activity and lymphocyte function during and after coronary artery bypass grafting in relation to the endocrine stress response. Anesthesiology. 1987; 67(4): 526-533.
9. Stenseth R, Bjella L, Berg EM, et al.: Thoracic epidural analgesia in aortocoronary bypass surgery. II. Effects of endocrine metabolic response. Acta Anaesthesiol Scand. 1994; 38(8): 834-839.
10. Chia YY, Liu K, Wang JJ, et al.: Intraoperative high dose fentanyl induces postoperative fentanyl tolerance. Can J Anaesth. 1999; 46(9): 872-877.
11. Duncan HP, Cloote A, Weir PM, et al.: Reducing stress response in the pre-bypass phase of open surgery in infants and young children: A comparison of different fentanyl doses. Brit J Anaesth. 2000; 84(5): 556-564.
12. Brand JM, Kirchner H, Poppe C, et al.: The effects of general anesthesia on human peripheral immune cell distribution and cytokine production. Clin Immunol Immunopathol. 1997; 83(2): 190-194.
13. Costa A, Benedetto V, Ricci C, et al.: Endocrine, hematological and immunological changes in surgical patients undergoing general anesthesia. Ital J Surg Sci. 1989; 19(1): 41-49.
14. Delvin EG, Clarke RSJ, Mirakhur RK, et al.: Effect of four i.v. induction agents on T-lymphocyte proliferations PHA in vitro. Br J Anaesth 1994; 73(3): 315-317.
15. Crozier TA, Muller JE, Quittkatt D, et al.: The effect of laparotomy on plasma concentrations of interleukin (IL)-1β and IL-6. Are there interactions with neuroendocrine secretion or postoperative temperature regulation? Anaesthesist. 1993; 42(6): 343-349.
16. Hellstrand K, Hermodsson S: Interleukin-2 can induce suppression of human natural killer cell cytotoxicity. Clin Exp Immunol. 1989; 77(3): 410-416.
17. Pechnick RN: Effect of opioids on the hypothalamo-pituitary-adrenal axis. Annu Rev Pharmacol Toxicol. 1993; 32: 353-382.
18. Homo-Delarch F, Dardenne M: The neuroendocrine-immune axis. Springer Semin Immunopathol. 1993; 14(3): 221-238.
19. Carr DJ, Gerbhardt BM, Paul D: Alpha adrenergic and mu-2 opioid receptors are involved in morphine-induced suppression of splenocyte natural killer activity. J Pharmacol Exp Ther. 1993; 264(3): 1179-1186.
20. Peterson PK, Molitor TW, Chao CC: Mechanisms of morphine induced immunomodulation. Biochem Pharmacol. 1993; 46(3): 343-348.
21. Yeager MP, Yu CT, Campbell AS, et al.: Effect of morphine and β-endorphine on human Fc receptor-dependent and natural killer cell functions. Clin Immunol Immunopathol. 1992; 62(3): 336-343.
22. Sibinga NE, Goldstein A: Opioid peptides and opioid receptors in cells of the immune system. Annu Rev Immunol. 1988; 6: 219-249.
23. Brune IB, Wilke W, Hensler T, et al.: Downregulation of T helper type 1 immune response and altered pro-inflammatory and ant-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery. Am J Surg. 1999; 177(1): 55-60.
24. Hensler T, Hecker H, Heeg K, et al.: Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect Immun. 1997; 65(6): 2283-2289.
25. Faist E, Mewes A, Baker CC, et al.: Prostaglandin E2 (PGE2)-dependent suppression of interleukin-2 (IL-2) production in patients with major trauma. J Trauma. 1987; 27(8): 837-848.
26. Beilin B, Shavit Y, Trabekin E, et al.: The effect of postoperative pain management on immune response to surgery. Anesth Analg. 2003; 97(3): 822-827.
27. Berguer R, Bravo N, Bowyer M, et al.: Major surgery suppresses maximal production of helper T-cell type 1 cytokines without potentiating the release of helper T-cell type 2 cytokines. Arch Surg. 1999; 134(5): 540-544.
28. Decker D, Schondorf M, Bidlingmaier F, et al.: Surgical stress induces a shift in the type-1/type-2 helper t-cell balance, suggesting down-regulation of cell mediated and up-regulation of antibody mediated immunity commensurate to the trauma. Surgery. 1996; 119(3): 316-325.
29. Volk T, Dopfmer UR, Schmutzler M, et al.: Stress induced IL-10 does not seem to be essential for early monocyte deactivation following cardiac surgery. Cytokine. 2003; 24(6): 237-243.
30. Volk T, Schmutzler M, Engelhardt L, et al.: Influence of aminosteroid and glucocorticoid treatment on inflammation and immune function during cardiopulmonary bypass. Crit Care Med. 2001; 29: 2137-2142.
31. Rumalla V, Calvano SE, Spotnitz AJ, et al.: The effect of glucocorticoid therapy on inflammatory responses to coronary artery bypass graft surgery. Arch Surg. 2001; 136: 1039-1044.
32. Naito Y, Tamai S, Shingu K, et al.: Response of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology. 1992; 77(3): 426-431.
33. Tsukada K, Katoh H, Shiojima M, et al.: Concentration of cytokines in peritoneal fluid after abdominal surgery. Eur J Surg. 1993; 159: 475-479.
34. Moore CM, Desborough JP, Powell H, et al.: Effects of extradural anesthesia on interleukin-6 and acute phase response to surgery. Br J Aneasth. 1994; 72(3): 272-279.
35. Stefano GB, Kushnerik V, Rodriquez M, et al.: Inhibitory effect of morphine on granulocyte stimulation by tumor necrosis factor and substance P. Int J Immunopharmacol 1994; 16(4): 329-334.
36. Stefano GB, Leung MK, Bilfinger TV, et al.: Effect of prolonged exposure to morphine on responsiveness of human and invertebrate immunocytes to stimulatory molecules. J Neuroimmunol. 1995; 63 (2): 175-181.