Serum IL-18 concentration does not depend on the presence of HCV-RNA in serum or in PBMC

Hepato-Gastroenterology

Volumn 55, Issue 81, 2008, Pages 212-215

  Majda Stanisławska, Ewa ^a   Pietrzak, Anna ^a   Brzezińska Błaszczyk, Ewa ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

HCV RNA; Hepatitis C; Interleukin 18; Peripheral blood mononuclear cells

Indexed keywords

ALPHA2B INTERFERON; INTERLEUKIN 18; RIBAVIRIN; VIRUS RNA;

ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADOLESCENT; ADULT; CHILD; FEMALE; HEPACIVIRUS; HUMANS; INTERLEUKIN-18; LEUKOCYTES, MONONUCLEAR; LIVER; MALE; RNA, VIRAL;

EID: 41549136917     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Dinarello CA: Interleukin-18. Methods 1999; 19:121-132.
2. Wereszczynska-Siemiatkowska U, Kosel J, Siemiatkowski A: Interleukin-18 as a new immunomodulator of some digestive tract diseases. Pol Merkuriusz Lek 2004; 16:282-284.
3. Lebel-Binay S, Berger A, Zinzindhoue F, Cugnenc PH, Thiunnn N, Fridman WH, Pages F: Interleukin-18: biological properties and clinical implications. Eur Cytokine Netw 2000; 11:15-25.
4. Finotto S, Siebler J, Hausding M, Schipp M, Wirtz S, Klein S, Protsehka M, Doganci A, Lehr HA, Trautwein C, Khosravi-Fahr R, Strand D, Lohse A, Galle PR, Blessing M, Neurath MF: Severe hepatic injury in interleukin-18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo. Gut 2004; 53:392-400.
5. Gracie JA, Robertson SE, McInnes IB: Interleukin-18. J Leukoc Biol 2003; 73:213-124.
6. Koziel MJ: Cytokines in viral hepatitis. Semin Liver Dis 1999; 19:157-169.
7. McGuinness PH, Painter D, Davies S, McCaughan GW: Increase in intrahepatic CD68 positive cells, MAC387 positive cells and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. Gut 2000; 46:260-269.
8. Ariki N, Morimoto Y, Yagi T, Oyama T, Cyouda Y, Sadamori H, Inagaki M, Urushihara N, Iwagaki H, Tanaka N: Activated T cells and soluble molecules in the portal venous blood of patients with cholestatic and hepatitis C virus-positive liver cirrhosis. Possible promotion of Fas/FasL-mediated apoptosis in the bile-duct cells and hepatocyte injury. J Int Med Res 2003; 31:170-180.
9. Marin-Serrano E, Rodriguez-Ramos C, Diaz F, Martin-Herrera L, Giron-Gonzales JA: Modulation of the anti-inflammatory interleukin 10 and of proapoptotic IL-18 in patients with chronic hepatitis C treated with interferon alfa and ribavirin. J Viral Hepat 2006; 13:230-234.
10. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ: Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19:1513-1520.
11. Dulak J, Funk H: Quantitative PCR in diagnostic of viral hepatitis. Hepatol Pol 1996; 3:31-39.
12. Yumoto E, Higashi T, Nouso K: Serum gamma-interferon-inducing factor (IL-18) and IL-10 levels in patients with acute hepatitis and fulminant hepatic failure. J Gastroenterol Hepatol 2002; 17:285-294.
13. Jia H, Du J, Zhu S, Ma Y, Cai H: Clinical observation of serum IL-18, IL-10 and sIL-2R levels in patients with chronic hepatitis C pre- and post antiviral treatment. Chin Med J 2003; 116:605-608.
14. Schvoerer E, Navas MC, Thumann C, Fuchs A, Meyer N, Habersetzer F, Stoll-Keller F: Production of interleukin-18 and interleukin-12 in patients suffering from chronic hepatitis C virus infection before antiviral therapy. J Med Virol 2003; 70:588-593.
15. Majda-Stanisławska E, Jozwiak B, Sidorkiewicz M, Berkan E, Piekarska A: HCV-RNA persistence In peripheral blond mononuclear cells after antiviral treatment: the difference between children's and adults' treatment response. E&C Hepatol 2006; 2:47-51.
16. Majda-Stanisławska E, Bednarek M, Jóźwiak B, Sidorkiewicz M, Piekarska A, Kuydowicz J: Effect of interferon alfa and ribavirin treatment on hepatitis C virus RNA in serum and peripheral blood mononuclear cells in children with chronic hepatitis C. Acta Gastroenterol Belg 2006; 69:187-190.
17. Takeuchi D, Yoshidome H, Kato A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Morita Y, Miyazaki M: Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice. Hepatology 2004; 39:699-710.
18. Spahr L, Garcia I, Bresson-Hadni S, Rubbia-Brandt L, Guler R, Olleros M, Chvatchko Y, Hadengue A: Circulating concentrations of interleukin-18, interleukin-18 binding protein and gamma interferon in patients with alcoholic hepatitis. Liver Int 2004; 24:582-587.
19. Vecchiet J, Falasca K, Cacciatore P, Zingarello P, Dalessandro M, Marinopiccoli M, D'Amico E, Palazzi C, Petrarca C, Conti P, Pizigallo E, Guagnano MT: Association between plasma interleukin-18 levels and liver injury in chronic hepatitis C virus infection and non-alcoholic fatty liver disease. Ann Clin Lab Sci 2005; 35:415-422.
20. Jia HY, Du J, Zhu SH, Ma YJ, Chen HY, Yang BS, Cai HF: The roles of serum IL-18, IL-10, TNF-alpha and sIL-2R in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int 2002; 1:378-382.
21. Falasca K, Ucciferri C, Dalessandro M, Zingarello P, Mancino P, Petraraca C, Pizigallo E, Conti P, Vecchiet J: Cytokine patterns correlate with the liver damage in patients with chronic hepatitis B and C. Ann Clin Lab Sci 2006; 36:144-150.
22. Spanakis NE, Garinis GA, Alexopoulos EC, Patrinos GP, Menounos PG, Sklavounou A, Malinos EEN, Gorgoulis VG, Valis D: Cytokine serum levels in patients with chronic HCV infection. J Clin Lab Anal 2002; 16:40-46.
23. Majda-Stanisławska E, Omulecka A, Szaflik I: Clinical picture of chronic hepatitis C in children - Polish experience. Acta Gastroenterol Belg 2000; 64:20-24.
24. Murata K, Yamamoto N, Kawakita T, Saito Y, Yamanaka Y, Sugimoto K, Shiraki K, Nakano T, Tameda Y: Up-regulation of IL-18 by interferon alpha-2b/ribavirin combination therapy induces anti-viral effect in patients with chronic hepatitis C. Hepatogastroenterology 2005; 52:547-551.
25. Napoli J, Bishop GA, McGuiness PH, Painter DM, McCaughan GW: Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 1996; 24:759-765.