"Intention to analyze" in pharmacogenomics studies in response

Cancer Epidemiology Biomarkers and Prevention

Volumn 17, Issue 3, 2008, Pages 740-741

  Munafò, Marcus R ^a   Johnstone, Elaine C ^b   Murphy, Michael F G ^b   Aveyard, Paul ^c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; NICOTINE PATCH; NICOTINE; NICOTINIC AGENT;

GENE IDENTIFICATION; GENETIC EPIDEMIOLOGY; GENOTYPE; LETTER; MEDICAL RESEARCH; PHARMACOGENOMICS; PRIORITY JOURNAL; TOBACCO DEPENDENCE; ADULT; DOUBLE BLIND PROCEDURE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; INTRADERMAL DRUG ADMINISTRATION; MALE; NOTE; POLYMERASE CHAIN REACTION; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SMOKING CESSATION; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADULT; CATECHOL O-METHYLTRANSFERASE; DOUBLE-BLIND METHOD; FEMALE; GENOTYPE; HUMANS; MALE; NICOTINE; NICOTINIC AGONISTS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEX FACTORS; SMOKING CESSATION; TOBACCO USE DISORDER; TREATMENT OUTCOME;

EID: 41549124604     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-08-0099     Document Type: Letter

References (18)

1. Imperial Cancer Research Fund. Effectiveness of a nicotine patch in helping people stop smoking: results of a randomised trial in general practice. Br Med J 1993;306:1304-8.
2. Imperial Cancer Research Fund. Randomised trial of nicotine patches in general practice: results at one year. Br Med J 1994;308:1476-7.
3. David SP, Munafo MR, Murphy MF, Proctor M, Walton RT, Johnstone EC. Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch. Pharmacogenomics J 2007.
4. David SP, Munafo MR, Murphy MF, Walton RT, Johnstone EC. The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial. Nicotine Tob Res 2007;9:225-31.
5. 108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial. Cancer Epidemiol Biomarkers Prev 2007;16:1065-9.
6. Johnstone EC, Yudkin PL, Hey K, et al. Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. Pharmacogenetics 2004;14:83-90.
7. Munafo MR, Elliot KM, Murphy MF, Walton RT, Johnstone EC. Association of the A-opioid receptor gene with smoking cessation. Pharmacogenomics J 2007;7:353-61.
8. Munafo MR, Johnstone EC, Wileyto EP, Shields PG, Elliot KM, Lerman C. Lack of association of 5-HTTLPR genotype with smoking cessation in a nicotine replacement therapy randomized trial. Cancer Epidemiol Biomarkers Prev 2006;15:398-400.
9. Yudkin P, Munafo MR, Hey K, et al. Effectiveness of nicotine patches in relation to genotype in women versus men: randomised controlled trial. Br Med J 2004;328:989-90.
10. Ioannidis JP. Journals should publish all "null" results and should sparingly publish "positive" results. Cancer Epidemiol Biomarkers Prev 2006;15:186.
11. Ioannidis JP. Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA 1998;279:281-6.
12. Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG, Ioannidis JP. Establishment of genetic associations for complex diseases is independent of early study findings. Eur J Hum Genet 2004;12:762-9.
13. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001;29:306-9.
14. Patsopoulos NA, Tatsioni A, Ioannidis JP. Claims of sex differences: an empirical assessment in genetic associations. JAMA 2007;298:880-93.
15. Ioannidis JP, Trikalinos TA. An exploratory test for an excess of significant findings. Clin Trials 2007;4:245-53.
16. Aveyard P, Brown K, Saunders C, et al. Weekly versus basic smoking cessation support in primary care: a randomised controlled trial. Thorax 2007;62:898-903.
17. 108/158Met genotype with smoking cessation. Pharmacogenet Genomics 2008;18:121-8.
18. Munafo MR, Flint J. Meta-analysis of genetic association studies. Trends Genet 2004;20:439-44