Effects of wortmannin on phosphorylation of PDK1, GSK3-β, PTEN and expression of Skp2 mRNA after ischemia/reperfusion injury in the mouse kidney

International Urology and Nephrology

Volumn 40, Issue 1, 2008, Pages 185-192

  Zheng, Xiangyi ^a   Xie, Liping ^a   Qin, Jie ^a   Shen, Huafeng ^a   Chen, Zhaodian ^a   Jin, Yongfeng ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Glycogen synthase kinase 3 ; Kidney failure; Phosphatidylinositol 3 kinase; Reperfusion injury; S phase kinase associated protein 2

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; S PHASE KINASE ASSOCIATED PROTEIN 2; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; KIDNEY INJURY; KIDNEY ISCHEMIA; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANDROSTADIENES; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GLYCOGEN SYNTHASE KINASE 3; KIDNEY; MALE; MICE; MICE, INBRED BALB C; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PTEN PHOSPHOHYDROLASE; RANDOM ALLOCATION; REPERFUSION INJURY; RNA, MESSENGER; S-PHASE KINASE-ASSOCIATED PROTEINS; TIME FACTORS; TREATMENT OUTCOME;

EID: 41549112503     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11255-007-9215-9     Document Type: Article

References (35)

1. Edelstein CL, Ling H, Wangsiripaisan A, Schrier RW (1997) Emerging therapies for acute renal failure. Am J Kidney Dis 30:S89-S95
2. Kelly KJ, Molitoris BA (2000) Acute renal failure in the new millennium: time to consider combination therapy. Semin Nephrol 20:4-19
3. Harris TK (2003) PDK1 and PKB/Akt: Ideal targets for development of new strategies to structure-based drug design. IUBMB Life 55:117-126
4. Andreucci M, Michael A, Kramers C et al (2003) Renal ischemia/ reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int 64:1189-1198
5. Kandel ES, Hay N (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 253:210-229
6. Brunet A, Bonni A, Zigmond MJ et al (1999) Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96:857-868
7. Downward J (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267
8. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657
9. Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602
10. Franke TF, Yang SI, Chan TO et al (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736
11. Toker A, Newton AC (2000) Cellular signaling: Pivoting around PDK-1. Cell 103:185-188
12. Shibata M, Yamawaki T, Sasaki T et al (2002) Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice. Brain Res 942:1-10
13. Matsui T, Tao J, del Monte F et al (2001) Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104:330-335
14. Xie LP, Zheng XY, Qin J et al (2006) Role of PI3-kinase/Akt signaling pathway in renal function and cell proliferation after renal ischemia/ reperfusion injury in mice. Nephrology 11:207-212
15. Takaoka M, Itoh M, Hayashi S, Kuro T, Matsumura Y (1999) Proteasome participates in the pathogenesis of ischemic acute renal failure in rats. Eur J Pharmacol 384:43-46
16. Itoh M, Takaoka M, Shibata A, Ohkita M, Matsumura Y (2001) Preventive effect of lactacystin, a selective proteasome inhibitor, on ischemic acute renal failure in rats. J Pharmacol Exp Ther 298:501-507
17. Zhang H, Kobayashi R, Galaktionov K, Beach D (1995) p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82:915-925
18. Schulman BA, Carrano AC, Jeffrey PD et al (2000) Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature 408:381-386
19. Singh VP, Saluja AK, Bhagat L et al (2001) Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest 108:1387-1395
20. Muller C, Dunschede F, Koch E, Vollmar AM, Kiemer AK (2003) Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway. Am J Physiol Gastrointest Liver Physiol 285:G769-778
21. Matsui T, Li L, Wu JC et al (2002) Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 277:22896-22901
22. Loverre A, Ditonno P, Crovace A et al (2004) Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: Differential modulation by rapamycin. J Am Soc Nephrol 15:2675-2686
23. Lieberthal W, Fuhro R, Andry CC et al (2001) Rapamycin impairs recovery from acute renal failure: Role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 281:F693-706
24. Smith KD, Wrenshall LE, Nicosia RF et al (2003) Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. J Am Soc Nephrol 14:1037-1045
25. Vanhaesebroeck B, Alessi DR (2000) The PI3K-PDK1 connection: More than just a road to PKB. Biochem J 346(Pt 3):561-576
26. Kis A, Yellon DM, Baxter GF (2003) Second window of protection following myocardial preconditioning: An essential role for PI3 kinase and p70S6 kinase. Mol Cell Cardiol 35:1063-1071
27. Budas GR, Sukhodub A, Alessi DR, Jovanovic A (2006) 3′Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium. FASEB J 20:2556-2558
28. Gross ER, Hsu AK, Gross GJ (2004) Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 94:960-966
29. Nishihara M, Miura T, Miki T et al (2006) Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase-3 beta. Am J Physiol Heart Circ Physiol 291:H748-755
30. Omori N, Jin G, Li F et al (2002) Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Brain Res 954:317-322
31. Cai Z, Semenza GL (2005) PTEN activity is modulated during ischemia and reperfusion: Involvement in the induction and decay of preconditioning. Circ Res 97:1351-1359
32. Bonventre JV (2003) Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 14(Suppl 1):S55-61
33. Carrano AC, Eytan E, Hershko A, Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1:193-199
34. Bornstein G, Bloom J, Sitry-Shevah D et al (2003) Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 278:25752-25757
35. Bouscary D, Pene F, Claessens YE et al (2003) Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood 101:3436-3443