Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations

Neuroscience Letters

Volumn 435, Issue 3, 2008, Pages 194-197

  Ohtsuki, T ^a,b   Horiuchi, Y ^a,b   Koga, M ^a,b   Ishiguro, H ^a,b   Inada, T ^c   Iwata, N ^d   Ozaki, N ^e   Ujike, H ^f   Watanabe, Y ^g   Someya, T ^g   Arinami, T ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

^d FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f OKAYAMA UNIVERSITY   (Japan)

^g NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Alternative splicing; Association; Netrin; Schizophrenia

Indexed keywords

NETRIN; NETRIN G1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHROMOSOME; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; FEMALE; GENE FREQUENCY; GENE STRUCTURE; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RNA SPLICING; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHROMOSOMES, HUMAN, PAIR 1; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLYCOPROTEINS; HAPLOTYPES; HUMANS; JAPAN; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA SPLICING; SCHIZOPHRENIA;

EID: 41549110578     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.02.053     Document Type: Article

References (6)

1. Aoki-Suzuki M., Yamada K., Meerabux J., Iwayama-Shigeno Y., Ohba H., Iwamoto K., Takao H., Toyota T., Suto Y., Nakatani N., Dean B., Nishimura S., Seki K., Kato T., Itohara S., Nishikawa T., and Yoshikawa T. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol. Psychiatry 57 (2005) 382-393
2. Archer H.L., Evans J.C., Millar D.S., Thompson P.W., Kerr A.M., Leonard H., Christodoulou J., Ravine D., Lazarou L., Grove L., Verity C., Whatley S.D., Pilz D.T., Sampson J.R., and Clarke A.J. NTNG1 mutations are a rare cause of Rett syndrome. Am. J. Med. Genet. A 140 (2006) 691-694
3. Arinami T., Ohtsuki T., Ishiguro H., Ujike H., Tanaka Y., Morita Y., Mineta M., Takeichi M., Yamada S., Imamura A., Ohara K., Shibuya H., Ohara K., Suzuki Y., Muratake T., Kaneko N., Someya T., Inada T., Yoshikawa T., Toyota T., Yamada K., Kojima T., Takahashi S., Osamu O., Shinkai T., Nakamura M., Fukuzako H., Hashiguchi T., Niwa S.I., Ueno T., Tachikawa H., Hori T., Asada T., Nanko S., Kunugi H., Hashimoto R., Ozaki N., Iwata N., Harano M., Arai H., Ohnuma T., Kusumi I., Koyama T., Yoneda H., Fukumaki Y., Shibata H., Kaneko S., Higuchi H., Yasui-Furukori N., Numachi Y., Itokawa M., and Okazaki Y. Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. Am. J. Hum. Genet. 77 (2005) 937-944
4. Eastwood S.L., and Harrison P.J. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. Neuropsychopharmacology 33 (2008) 933-945
5. Levinson D.F., and Mowry B.J. Genetics of schizophrenia. In: Pfaff D.W., Berrettini W.H., Maxson S.C., and Joh T.H. (Eds). Genetic Influences on Neural and Behavioral Functions (2000), CRC Press, New York 47-82
6. Lin J.C., Ho W.H., Gurney A., and Rosenthal A. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nat. Neurosci. 6 (2003) 1270-1276