Potential interaction between warfarin and high dietary protein intake

Pharmacotherapy

Volumn 28, Issue 4, 2008, Pages 536-539

  Hornsby, Lori B ^a,b   Hester, E Kelly ^a   Donaldson, Amy R ^a  

^a AUBURN UNIVERSITY   (United States)

^b Montgomery Family Medicine Residency Program   (United States)

Author keywords

Anticoagulation; Dietary effects; Drug diet interaction; High protein diet; International normalized ratio; Low carbohydrate diet; Warfarin

Indexed keywords

CYTOCHROME P450; WARFARIN;

ADULT; ALBUMIN BLOOD LEVEL; ANTICOAGULATION; AORTA VALVE REPLACEMENT; ARTICLE; CASE REPORT; DRUG DOSE INCREASE; DRUG METABOLISM; FOOD DRUG INTERACTION; HUMAN; INTERNATIONAL NORMALIZED RATIO; LIVER FUNCTION TEST; LOW CARBOHYDRATE DIET; MALE; PATIENT MONITORING; PROTEIN DIET; PROTEIN INTAKE;

ANTICOAGULANTS; CYTOCHROME P-450 ENZYME SYSTEM; DIETARY CARBOHYDRATES; DIETARY PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD-DRUG INTERACTIONS; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; WARFARIN;

EID: 41549096409     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.28.4.536     Document Type: Article

References (10)

1. Beatty S, Mehta B, Rodis J. Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets. Ann Pharmacother 2005;39(4):744-7.
2. Fagan T, Oexmann M. Effects of high protein, high carbohydrate, and high fat diets on laboratory parameters. J Am Coll Nutr 1987;6(4):333-43.
3. Beatty S, Mehta B, Rodis J. Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets [letter]. Ann Pharmacother 2005;39(7-8):1372.
4. Fagan T, Walle T, Oexmann M, Walle U, Bai S, Gaffney T. Increased clearance of propranolol and theophylline by high-protein compared with high-carbohydrate diet. Clin Pharmacol Ther 1987;41(4):402-6.
5. Feldman C, Hutchinson V, Sher T, Feldman B, Davis W. Interaction between nutrition and theophylline metabolism in children. Ther Drug Monit 1982;4(1):69-76.
6. Takahashi H, Echizen H. Pharmacogenetics of warfarin elimination and its clinical implications. Clin Pharmacokinet 2001;40(8):587-603.
7. Anderson KE, Kappas A. Dietary regulation of cytochrome P450. Annu Rev Nutr 1991;11:141-67.
8. Lee J, Suh O, Lee M. Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 enzymes. Arch Pharm Res 2004;27(7):693-712.
9. Cancino-Badias L, Reyes R, Nosti R, et al. Modulation of rat liver cytochrome P450 by protein restriction assessed by biochemical and bacterial mutagenicity methods. Mutagenesis 2003;18(1):95-100.
10. Schwabedissen C, Mevissen V, Schmitz F, et al. Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not. Eur J Clin Pharmacol 2006;62(9):713-20.