Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H- naphthol[1,2-b]pyran-5,6-dione (ARQ 501; β-lapachone) in whole blood

Drug Metabolism and Disposition

Volumn 36, Issue 4, 2008, Pages 641-648

  Miao, Xiu Sheng ^a   Song, Pengfei ^a   Savage, Ronald E ^a   Zhong, Caiyun ^a   Yang, Rui Yang ^a   Kizer, Darin ^a   Wu, Hui ^a   Volckova, Erika ^a   Ashwell, Mark A ^a   Supko, Jeffrey G ^b   He, Xiaoying ^b   Chan, Thomas C K ^a  

^a ARQULE INC   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (5 FORMYL 2,2 DIMETHYL 3,4 DIHYDRO 2H PYRAN 6 YL)BENZOIC ACID; 2,2 DIMETHYL 3,4 DIHYDRO 2H,5H PYRANO[3,2 C]CHROMEN 5 ONE; 2,2 DIMETHYL 3,4 DIHYDROINDENO[1,2 B]PYRAN 5(2H) ONE; 2,2 DIMETHYL 3,4 DIHYDROPYRANO[3,2 C]ISOCHROMEN 6(2H) ONE; 6 (2 CARBOXYPHENYL) 2,2 DIMETHYL 3,4 DIHYDRO 2H PYRAN 5 CARBOXYLIC ACID; ARQ 501; BETA LAPACHONE; CARBONYL DERIVATIVE; CARBOXYLIC ACID; DICARBOXYLIC ACID; DRUG METABOLITE; OXYGEN; PYRAN DERIVATIVE; PYRONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER PATIENT; CONTROLLED STUDY; COVALENT BOND; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG OXIDATION; ERYTHROCYTE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; LACTONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RAT; STRUCTURE ANALYSIS;

ANIMALS; DOGS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HAPLORHINI; HUMANS; MICE; NAPHTHOQUINONES; PROTEIN BINDING; RATS; SPECIES SPECIFICITY;

CANIS FAMILIARIS; RATTUS;

EID: 41549094544     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.018572     Document Type: Article

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