Analysis of genetic variations in the resistin gene shows no associations with obesity in women

Obesity

Volumn 16, Issue 4, 2008, Pages 905-907

  Beckers, Sigri ^a   Peeters, Armand V ^a   Freitas, Fenna De ^a   Mertens, Ilse L ^b   Hendrickx, Jan Jaap ^b   Van Gaal, Luc F ^b   Van Hul, Wim ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

RESISTIN; RETN PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BELGIUM; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; MIDDLE AGED; OBESITY; PREMENOPAUSE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; BELGIUM; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREMENOPAUSE; RESISTIN; VARIATION (GENETICS);

EID: 41549089289     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2007.131     Document Type: Article

References (21)

1. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006;444:875-880.
2. Steppan CM, Bailey ST, Bhat S et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-312.
3. Holcomb IN, Kabakoff RC, Chan B et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMSO J 2000;19:4046-4055.
4. Kim KH, Lee K, Moon YS, Sul HS. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 2001;276:11252-11256.
5. Pang SS, Le YY. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol 2006;3:29-34.
6. Engert JC, Vohl MC, Williams SM et al. 5′ flanking variants of resistin are associated with obesity. Diabetes 2002;51:1629-1634.
7. Bouchard L, Weisnagel SJ, Engert JC et al. Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study. J Endocrinol Invest 2004;27:1003-1009.
8. Mattevi VS, Zembrzuski VM, Hutz MH. A resistin gene polymorphism is associated with body mass index in women. Hum Genet 2004;115:208-212.
9. Smith SR, Bai F, Charbonneau C, Janderova L, Argyropoulos G. A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Diabetes 2003;52:1611 -1618.
10. Sentinelli F, Romeo S, Area M et al. Human resistin gene, obesity, and type 2 diabetes: mutation analysis and population study. Diabetes 2002;51:860-862.
11. Ochi M, Osawa H, Onuma H et al. The absence of evidence for major effects of the frequent SNP +299G>A in the resistin gene on susceptibility to insulin resistance syndrome associated with Japanese type 2 diabetes. Diabetes Res Clin Pract 2003;61:191-198.
12. Cho YM, Youn BS, Chung SS et al. Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans. Diabetologia 2004;47:559-565.
13. Lenth RV. Java Applets for Power and Sample Size. 〈http://www.stat. uiowa. edu/~rlenth/Power〉 (2006). Accessed 20 June 2007.
14. Xu JY, Sham PC, Xu A et al. Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study. Clin Endocrinol (Oxf) 2007:66:211-217.
15. Gouni-Berthold I, Giannakidou E, Faust M et al. Resistin gene 3'-untranslated region +62G→A polymorphism is associated with hypertension but not diabetes mellitus type 2 in a German population. J Intern Med 2005;258:518-526.
16. Steppan CM, Brown EJ, Wright CM et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 2001;98:502-506.
17. Nagaev I, Smith U. Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochem Biophys Res Commun 2001;285:561-564.
18. Savage DB, Sewter CP, Klenk ES et al. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001;50:2199-2202.
19. Patel L, Buckels AC, Kinghorn IJ et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 2003;300:472-476.
20. Barrett JC, Fry B, Mailer J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-265.
21. Becker T, Knapp M. Maximum-likelihood estimation of haplotype frequencies in nuclear families. Genet Epidemiol 2004;27:21-32.