Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: Tumor escape by antigen loss and loss of MHC expression

Journal of Immunotherapy

Volumn 27, Issue 3, 2004, Pages 184-190

  Khong, Hung T ^a   Wang, Qiong J ^a   Rosenberg, Steven A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Immunoselection; Melanoma antigens; Tumor escape; Tumor infiltrating lymphocytes; Vaccination

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BETA 2 MICROGLOBULIN; CISPLATIN; COMPLEMENTARY DNA; CYTOKINE; DACARBAZINE; FREUND ADJUVANT; GAMMA INTERFERON; GLYCOPROTEIN GP 100; HLA A ANTIGEN; HLA A2 ANTIGEN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B ANTIGEN; HLA C ANTIGEN; HLA DP ANTIGEN; INTERLEUKIN 2; MELAN A; MELANOMA ANTIGEN; MONOPHENOL MONOOXYGENASE; RNA; TRANSCRIPTION FACTOR SOX10; TYROSINASE RELATED PROTEIN 2; UNCLASSIFIED DRUG; VINBLASTINE;

ADULT; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; BRAIN METASTASIS; BRAIN RADIATION; CANCER IMMUNOTHERAPY; CASE REPORT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; FEMALE; GENE MUTATION; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX; MELANOMA; MELANOMA CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE;

EID: 4143149381     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002371-200405000-00002     Document Type: Article

References (15)

1. Rosenberg SA, Yang JC, Schwartzentruber DJ, et al. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med. 1998;4:321-327.
2. Jager E, Chen YT, Drijfhout JW, et al. Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med. 1998;187:265-270.
3. Khong HT, Rosenberg SA. The Waardenburg syndrome type 4 gene, SOX10, is a novel tumor-associated antigen identified in a patient with a dramatic response to immunotherapy. Cancer Res. 2002;62:3020-3023.
4. Khong HT, Rosenberg SA. Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. J Immunol. 2002;168:951-956.
5. de Vries TJ, Fourkour A, Wobbes T, et al. Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions. Cancer Res. 1997;57:3223-3229.
6. Mashino K, Sadanaga N, Tanaka F, et al. Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas. Br J Cancer. 2001;85:713-720.
7. Cheng L, Guan Y, Li L, et al. Expression in normal human tissues of five nucleotide excision repair genes measured simultaneously by multiplex reverse transcription-polymerase chain reaction. Cancer Epidemiol Biomarkers Prev. 1999;8:801-807.
8. Restifo NP, Marincola FM, Kawakami Y, et al. Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy. J Natl Cancer Inst. 1996;88:100-108.
9. Coulie PG, Ikeda H, Baurain JF, Chiari R. Antitumor immunity at work in a melanoma patient. Adv Cancer Res. 1999;76:213-242.
10. Maeurer MJ, Gollin SM, Martin D, et al. Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen. J Clin Invest. 1996; 98:1633-1641.
11. Rosenberg SA, Yang JC, Robbins PF, et al. Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma. J Immunother. 2003;26:385-393.
12. Durda PJ, Dunn IS, Rose LB, et al. Induction of "antigen silencing" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression. Mol Cancer Res. 2003;1:411-419.
13. Potterf SB, Furumura M, Dunn KJ, et al. Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3. Hum Genet. 2000;107:1-6.
14. Widtund HR, Fisher DE. Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene. 2003;22:3035-3041.
15. Du J, Miller AJ, Widlund HR, et al. MLANA/MART1 and SILV/MEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003;163:333-343.