Computational chemical analysis of the retention of acidic drugs on a pentyl-bonded silica gel in reversed-phase liquid chromatography

Journal of Chromatographic Science

Volumn 42, Issue 7, 2004, Pages 354-360

  Hanai, Toshihiko ^a   Miyazaki, Rie ^b   Koseki, Ayako ^b   Kinoshita, Toshio ^b  

^a HEALTH RESEARCH FOUNDATION   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; 4 HYDROXYBENZOIC ACID; ACID; ADSORBENT; AMOXICILLIN; BARBITURIC ACID; BENZOIC ACID; DIMETHYLPENTYLSILANE; FUROSEMIDE; IBUPROFEN; INDOMETACIN; IOPANOIC ACID; MEFENAMIC ACID; NALIDIXIC ACID; NAPROXEN; NICOTINIC ACID; PHENOL DERIVATIVE; PHENYLBUTAZONE; PROBENECID; SALICYLIC ACID; SILANE DERIVATIVE; SILICA GEL; SULFAMETHOXAZOLE; TOLAZAMIDE; TOLBUTAMIDE; UNCLASSIFIED DRUG; WARFARIN;

ADSORPTION; ARTICLE; CALCULATION; CHEMICAL ANALYSIS; COMPUTER PROGRAM; CORRELATION COEFFICIENT; DRUG DETERMINATION; DRUG SOLUBILITY; ENERGY; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE;

EID: 4143138566     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/42.7.354     Document Type: Article

References (11)

1. T. Hanai. HPLC A Practical Guide. Royal Society of Chemistry, Cambridge, U.K., 1999, pp. 109-32.
2. N. Boder, Z. Gabanyi, and C.-K. Wong. A new method for the estimation of partition coefficient. J. Am. Chem. Soc. 111: 3783-86 (1989).
3. R.F. Rekker. The Hydrophobic Fragmental Constant. Elsevier, Amsterdam, the Netherlands, 1977.
4. T. Hanai, K. Koizumi, and T. Kinoshita. Prediction of retention factors of phenolic and nitrogen-containing compounds in reversed-phase liquid chromatography based on log P and pKa obtained by computational chemical calculation. J. Liq. Chromatogr. Rel. Technol. 23: 363-85 (2000).
5. T. Hanai. Separation of polar compounds using carbon columns. J. Chromatogr. A 989: 183-96 (2003).
6. T. Hanai, H. Hatano, N. Nimura, and T. Kinoshita. Computer-aided analysis of molecular recognition in chromatography. Analyst 118: 1371-74 (1993).
7. CAChe manual. Fujitsu (Sony-Techtronix), Tokyo, Japan, 1994, 2002.
8. T. Hanai, Chi. Mizutani, and H. Homma. Computational chemical simulation of chromatographic retention of phenolic compounds. J. Liq. Chromatogr. & Rel. Technol. 26: 2031-39 (2003).
9. T. Hanai, K. Koizumi, T. Kinoshita, R. Arora, and F. Ahmed. Prediction of pKa values of phenolic and nitrogen-containing compounds by computational chemical analysis compared to those measured by liquid chromatography. J. Chromatogr. A 762: 55-61 (1997).
10. T. Hanai. Simulation chromatography of phenolic compounds using a computational chemical method. J. Chromatogr. A 1027: 279-87 (2004).
11. D.J. Pietrzyk and C.-H. Chu. Separation of organic acids on Amberlite-XAD copolymers by reversed-phase high pressure liquid chromatography. Anal. Chem. 49: 860-67 (1977).