Growth hormone use in children with idiopathic short stature

Annals of Pharmacotherapy

Volumn 38, Issue 9, 2004, Pages 1460-1468

  Weise, Karen L ^a,b   Nahata, Milap C ^a,c,d  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Pharmacotherapy and Translational Research   (United States)

^d THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Human growth hormone; Idiopathic short stature; Somatrem; Somatropin

Indexed keywords

HUMAN GROWTH HORMONE; SOMATREM;

BRAIN PSEUDOTUMOR; CARDIOVASCULAR DISEASE; CHILD; CLINICAL TRIAL; DRUG DOSE REGIMEN; DRUG INDICATION; DRUG USE; FOOD AND DRUG ADMINISTRATION; GLUCOSE INTOLERANCE; HUMAN; HYPERTENSION; HYPOTHYROIDISM; LEUKEMIA; MEDICAL ETHICS; MEDICAL LITERATURE; MEDLINE; PATIENT SELECTION; PRIORITY JOURNAL; PUBLICATION; REVIEW; SHORT STATURE; SIDE EFFECT;

CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; RECOMBINANT PROTEINS;

EID: 4143138530     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1D548     Document Type: Review

References (30)

1. Eli Lilly and Company. Briefing document: Humatrope for non-growth hormone deficient short stature. Endocrinologic and Metabolic Drugs Advisory Committee 2003. www.fda.gov/ohrms/dockets/ac/03/briefing/3957bl.htm (accessed 2003 Aug 10).
2. Allen DB, Brook CGD, Bridges NA, Hindmarsh PC, Guyda HJ, Frazier D. Therapeutic controversies: growth hormone (GH) treatment of non-GH deficient subjects. J Clin Endocrinol Metab 1994;79:1239-48.
3. Kamp GA, Wit JM. High-dose growth hormone therapy in idiopathic short stature. Horm Res 1998;49(suppl 2):67-72.
4. Chemaitilly W, Trivin C, Souberbielle JC, Brauner R. Assessing short-statured children for growth hormone deficiency. Horm Res 2003;60:34-42.
5. American Academy of Pediatrics Committee on Drugs and Committee on Bioethics. Considerations related to the use of recombinant human growth hormone in children. Pediatrics 1997;99:122-9.
6. Hintz RL. Growth hormone treatment of idiopathic short stature. Horm Res 1996;46:208-14.
7. Minnesota Health Technology Advisory Committee Report 2000. The use of human growth hormone (HGH) for children with idiopathic short stature. www.health.state.mn.us/htac/hgh.htm (accessed 2003 Aug 15).
8. Finkelstein BS, Imperiale TF, Speroff T, Marrero U, Radcliffe DJ, Cuttler L. Effect of growth hormone therapy on height in children with idiopathic short stature. Arch Pediatr Adolesc Med 2002;156:230-40.
9. Hintz RL, Attie KM, Baptista J, Roche A. Effect of growth hormone treatment on adult height of children with idiopathic short stature. N Engl J Med 1999;340:502-7.
10. FDA talk paper. FDA approves Humatrope for short stature. July 25, 2003. U.S. Food and Drug Administration. www.fda.gov/bbs/topics/ANSWERS/2003/ANS01242. html (accessed 2003 Aug 10).
11. Fitzgerald PA. Hypothalamic & pituitary hormones. In: Katzung BG, ed. Clinical pharmacology. 8th ed. New York: Lange Medical Books/McGraw-Hill, 2001:629-30.
12. Parks JS, Sunders WB, Hormones of the hypothalamus and pituitary and hypopituitarism. In: Behrman RE, Kliegman R, Jenson HB, eds. Nelson textbook of pediatrics. 17th ed. New York: WB Saunders Books, 2003: 1845-52.
13. Prescribing information. Humatrope (somatropin [rDNA origin] for injection). Indianapolis: Eli Lilly, July 2003.
14. Prescribing information. Genotropin (somatropin [rDNA origin] for injection). Kalamazoo, MI: Pharmacia & Upjohn, April 2003.
15. Zadik Z, Mira U, Landau H. Final height after growth hormone therapy in peripubertal boys with a subnormal integrated concentration of growth hormone. Horm Res 1992;37:150-5.
16. Wit JM, Boersma B, de Muinick Keizer-Schrama SM, Nienhuis HE, Oostdijk W, Otten BJ, et al. Long-term results of growth hormone therapy in children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. Dutch Growth Hormone Working Group. Clin Endocrinol (Oxf) 1995;42:365-72.
17. Hindmarsh PC, Brook CGD. Final height of short normal children treated with growth hormone. Lancet 1996;348:13-6.
18. Lanes R. Effects of two years of growth hormone treatment in short, slowly growing non-growth hormone deficient children. J Pediatr Endocrinol Metab 1995;8:167-71.
19. McCaughey ES, Mulligan J, Voss LD, Betts PR. Randomised trial of growth hormone in short normal girls. Lancet 1998;351:940-4.
20. Barton JS, Bardiner HM, Cullen S, Hindmarsh PC, Brook CGD, Preece MA. The growth and cardiovascular effects of high dose growth hormone therapy in idiopathic short stature. Clin Endocrinol (Oxf) 1995; 42:619-26.
21. Wit JM, Rekers-Mombarg LTM, Dutch Hormone Working Group. Final height gain by GH therapy in children with idiopathic short stature is dose dependent. J Clin Endocrinol Metab 2002;82:604-11.
22. Schmitt K, Blumel P, Waldhor T, Lassi M, Tulzer G, Frisch H. Short- and long-term (final height) data in children with normal variant short stature treated with growth hormone. Eur J Pediatr 1997;156:680-3.
23. Chanoine JP, Vanderschueren-Lodeweyckx M, Maes M, Thiry-Counson G, Craen M, Van Vliet G. Growth hormone (GH) treatment in short normal children: absence of influence of time of injection and resistance to GH autofeedback. J Clin Endocrinol Metab 1991;73:1269-74.
24. Guyda HJ. Growth hormone therapy for non-growth hormone-deficient children with short stature. Curr Opin Pediatr 1998;10:416-21.
25. FDA Endocrinologic and Metabolic Drugs Advisory Committee June 10th 2003 meeting transcript. www.fda.gov/ohrms/dockets/ac/03/transcripts/3957T1.htm (accessed 2003 Aug 10).
26. Saenger P, Attie KM, DiMartino-Nardi J, Hintz R, Frahm L, Frane JW, et al. Metabolic consequences of 5-year growth hormone (GH) therapy in children treated with GH for idiopathic short stature. J Clin Endocrinol Metab 1998;83:3115-20.
27. Soliman AT, Khadir MMA. Growth parameters and predictors of growth in short children with and without growth hormone (GH) deficiency treated with human GH: a randomized controlled study. J Trop Pediatr 1996;42:281-6.
28. Barton JS, Cullen S, Hindmarsh PC, Brook CGD, Preece MA. Growth hormone treatment in idiopathic short stature: a preliminary analysis of cardiovascular effects. Acta Paediatr 1992;383(suppl):35-8.
29. Lippe B. Genotropin (somatropin [rDNA origin] for injection). Rockville, MD: FDA/CDER/Office of Drug Safety, MedWatch Alert (letter). May 30, 2003.
30. Eiholzer U, Nonimann Y, L'Allemand D. Fatal outcome of sleep apnoea in PWS during the initital phase of growth hormone treatment. Horm Res 2002;58(suppl 3):24-6.