High altitude training of dogs results in elevated erythropoietin and endothelin-1 serum levels

Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Volumn 138, Issue 3, 2004, Pages 355-361

  Glaus, Tony M ^a   Grenacher, Beat ^a   Koch, Daniel ^a   Reiner, Barbel ^a   Gassmann, Max ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Acclimatisation; Big endothelin; Dogs; Endothelin 1; Erythropoietin; High altitude; Hypoxia; VEGF

Indexed keywords

BIG ENDOTHELIN 1; ENDOTHELIN 1; ERYTHROPOIETIN; VASCULOTROPIN;

ALTITUDE ACCLIMATIZATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CELL LEVEL; CONTROLLED STUDY; DOG; ERYTHROCYTOSIS; HUMORAL IMMUNITY; HYPOXIA; NONHUMAN; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; VASOCONSTRICTION;

CANIS FAMILIARIS;

EID: 4143133178     PISSN: 10956433     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpb.2004.05.008     Document Type: Article

References (32)

1. Banks R.E., Forbes M.A., Kinsey S.E., Stanley A., Ingham E., Walters C., Selby P.J. Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets. Significance for VEGF measurements and cancer biology. Br. J. Cancer. 77:1998;956-964
2. Biondo A.W., Wiedmeyer C.E., Sisson D.D., Solter P.F. Comparative sequences of canine and feline endothelin1. Vet. Clin. Pathol. 32:2003;188-194
3. Chen Y.F., Oparil S. Endothelin and pulmonary hypertension. J. Cardiovasc. Pharmacol. 35(4 Suppl. 2):2000;S49-S53
4. Christou H., Yoshida A., Arthur V., Morita T., Kourembanas S. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 18:1998;768-776
5. Clifford C.A., Hughes D., Beal M.W., Maeckin A.J., Henry W., Shofer F.S., Sorenmo K.U. Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma. J. Vet. Intern. Med. 14:2001;131-135
6. Cook S.M., Lothrop C.D. Serum erythropoietin concentrations measured by radioimmunoassay in normal, polycythemic, and anemic dogs and cats. J. Vet. Intern. Med. 8:1994;18-25
7. Douglas S.A., Vickery-Clark L.M, Ohlstein E.H. Endothelin-1 does not mediate hypoxic vasoconstriction in canine isolated blood vessels: effect of BQ-123. Br. J. Pharmacol. 108:1993;418-421
8. Glaus T.M., Hauser K., Hassig M., Lipp B., Reusch C.E. Non-invasive measurement of cardiovascular effects of chronic hypoxaemia on dogs living at moderately high altitude. Vet. Rec. 152:2003;800-803
9. Glaus T.M., Hassig M., Baumgartner C., Reusch C.E. Pulmonary hypertension induced by hypoxia at different high-altitude levels in dogs. Vet. Res. Commun. 27:2003;661-670
10. Glaus T.M., Tomsa K., Hassig M. Echocardiographic changes induced by moderate to marked hypobaric hypoxia in dogs. Vet. Radiol. Ultrasound. 45:2004;233-237
11. Goerre S., Wenk M., Bartsch P., Luscher T.F., Niroomand F., Hohenhaus E., Oelz O., Reinhart W.H. Endothelin-1 in pulmonary hypertension associated with high-altitude exposure. Circulation. 91:1995;359-364
12. Grosenbaugh D.A., Gadawski J.E., Muir W.W. Evaluation of a portable clinical analyser in a veterinary hospital setting. J. Am. Vet. Med. Assoc. 213:1998;691-694
13. Grover R.F., Johnson R.L., McCullough R.G., McCullough R.E., Hofmeister S.E., Campbell W.B., Reynolds R.C. Pulmonary hypertension and pulmonary vascular reactivity in beagles at high altitude. J. Appl. Physiol. 65:1988;2632-2640
14. Grover R.F., Reeves J.T., Rowell L.B., Piantadosi C.A., Saltzman H.A. The influence of environmental factors on the cardiovascular system. Alexander R.W., Schlant R.C., Fuster V. Hurst's The Heart. 9th Ed.:1998;2327-2345 McGraw-Hill, New York
15. Heinicke K., Prommer N., Cajigal J., Viola T., Behn C., Schmidt W. Long-term exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin plasma levels in man. Eur. J. Appl. Physiol. Occup. Physiol. 88:2003;535-543
16. Hopfl G., Ogunshola O., Gassmann M. HIFs and tumors - causes and consequences. Am. J. Physiol. 286:2004;R608-R623
17. Horgan M.J., Pinheiro J.M.P., Malik A.B. Mechanism of endothelin-1-induced pulmonary vasoconstriction. Circ. Res. 69:1991;157-164
18. Keith I.M. The role of endogenous lung neuropeptides in regulation of the pulmonary circulation. Physiol. Res. 49:2000;519-537
19. Koistinen P.O., Rusko H., Irjala K., Rajamaki A., Penttinen K., Sarparanta V.P., Karpakka J., Leppaluoto J. EPO, red cells, and serum transferring receptor in continuous and intermittent hypoxia. Med. Sci. Sports Exerc. 32:2000;800-804
20. Louzier V., Raffestin B., Leroux A., Branellec D., Caillaud J.M., Levame M., Eddahibi S., Adnot S. Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension. Am. J. Physiol., Lung Cell. Mol. Physiol. 284:2003;L926-L937
21. Mazzeo R.S., Wolfel E.E., Butterfield G.E., Reeves J.T. Sympathetic response during 21 days at high altitude (4300 m) as determined by urinary and arterial catecholamines. Metabolism. 43:1994;1226-1232
22. Partovian C., Adnot S., Raffestin B., Louzier V., Levame M., Mavier I.M., Lemarchand P., Eddahibi S. Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am. J. Respir. Cell Mol. Biol. 23:2000;762-771
23. Pechereau D., Martel P. Plasma erythropoietin concentrations in dogs and cats: reference values and changes with anaemia and/or chronic renal failure. Res. Vet. Sci. 62:1997;185-188
24. Sanchez C., Merino C., Figallo M. Simultaneous measurement of plasma volume and cell mass in polycythemia of high altitude. J. Appl. Physiol. 28:1970;775-778
25. Scheidegger P., Weiglhofer W., Suarez S., Kaser-Hotz B., Steiner R., Ballmer-Hofer K., Jaussi R. Vascular endothelial growth factor (VEGF) and its receptors in tumour-bearing dogs. Biol. Chem. 380:1999;1449-1454
26. Syvertsen G.R., Harris J.A. Erythropoietin production in dogs exposed to high altitude and carbon monoxide. Am. J. Physiol. 225:1973;293-299
27. Voelkl N., Cool C., Taraceviene-Stewart L., Geraci M.W., Yeager M., Bull T., Kasper M., Tuder R.M. Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodelling in severe pulmonary hypertension. Crit. Care Med. 30(5 Suppl.):2002;251-265
28. Vollmar A.M., Preusser U., Gerbes A.L., Kraft W., Schulz R. Endothelin concentration in plasma of healthy dogs and dogs with congestive heart failure, renal failure, diabetes mellitus, and hyperadrenocorticism. J. Vet. Intern. Med. 9:1995;105-111
29. Webb N.J., Bottomley M.J., Watson C.J., Brenchley P.E. Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: implications for measurement of circulating VEGF levels in clinical disease. Clin. Sci. 94:1998;395-404
30. Wenger R.H. Mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 203:2000;1253-1263
31. Wergin M.C., Kaser-Hotz B. Plasma vascular endothelial growth factor (VEGF) measured in seventy dogs with spontaneously occurring tumours. In Vivo. 18:2004;15-20
32. Wolfel E.E., Selland M.A., Mazzeo R.S., Reeves J.T. Systemic hypertension at 4300 m is related to sympathoadrenal activity. J. Appl. Physiol. 76:1994;1643-1650