Proximal tubular kidney damage and tenofovir: A role for mitochondrial toxicity? [1]

AIDS

Volumn 18, Issue 12, 2004, Pages 1741-1742

  Saumoy, Maria ^a   Vidal, Francesc ^a   Peraire, Joaquim ^a   Sauleda, Silvia ^b   Vea, Albert Martínez ^a   Viladés, Consuelo ^a   Ribera, Esteve ^b   Richart, Cristóbal ^a  

^a HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ASCORBIC ACID; BICARBONATE; DIDANOSINE; HYDROXYUREA; LOPINAVIR PLUS RITONAVIR; POTASSIUM; TENOFOVIR;

ADULT; ANAMNESIS; CASE REPORT; CLINICAL FEATURE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY TUBULE DISORDER; LABORATORY TEST; LETTER; MALE; MITOCHONDRIAL TOXICITY; MITOCHONDRION; PHYSICAL EXAMINATION; PRIORITY JOURNAL; TREATMENT WITHDRAWAL;

ADENINE; ADULT; ANTI-HIV AGENTS; DNA, MITOCHONDRIAL; HIV INFECTIONS; HIV-1; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MALE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS;

EID: 4143128772     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aids.0000131386.38103.37     Document Type: Letter

References (9)

1. Karras F, Lafaurie M, Furco A, Bourgarit A, Droz D, Sereni D, et al. Tenofovir-related nephotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome and nephrogenic diabetes insipidus. Clin Infect Dis 2003, 36:1070-1073.
2. Verhelst D, Monge M, Meynard J-L, Fouqueray B, Mougenot B, Girard P-M, et al. Fanconi syndrome and renal failure induced by tenofovir: a first case report. Am J Kidney Dis 2002, 40:1331-1333.
3. Creput C, Gonzalez-Canali G, Hill G, Pikelty C, Kazatchkine M, Nochy D. Renal lesions in HIV-1-positive patient treated with tenofovir. AIDS 2003, 17:935-937.
4. Schaaf B, Aries SP, Kramme E, Steinhoff J, Dalhoff K. Acute renal failure associated with tenofovir treatment in a patient with adquired immunodeficiency syndrome. Clin Infect Dis 2003, 37:e41-e43.
5. Lee JL, Marasok RD. Acute tubular necrosis in a patient receiving tenofovir. AIDS 2003, 17:2543-2545.
6. Cihlar T, Ho ES, Lin DC, Mulato AS. Human renal organic anion transporter (hOAT1) and its role in nephrotoxicity of antiviral nucleoside analogs. Nucleos Nucleot Nucleic Acids 2001, 20:641-648.
7. Cihlar T, Birkus G, Greenwalt GD, Hitchcock MIM. Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors. Antivir Res 2002, 54:37-45.
8. Tanji N, Tanji K, Kambham N, Markowitz GS, Bell A, D'Agati VD. Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Hum Pathol 2001, 32:734-740.
9. Birkus G, Hitchcock MJM, Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 2002, 46:716-723.