Prenatal methylazoxymethanol exposure alters evoked responses in fetal rats

Neurotoxicology and Teratology

Volumn 26, Issue 5, 2004, Pages 663-671

  Kleven, Gale A ^a   Queral, Laila ^a   Robinson, Scott R ^a  

^a E11 SSH   (United States)

Author keywords

Fetal movement; Methylazoxymethanol; Motor coordination

Indexed keywords

METHYLAZOXYMETHANOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BEHAVIORAL SCIENCE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EVOKED RESPONSE; MOTOR COORDINATION; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; UTERUS;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; FACE; FEMALE; INJECTIONS, INTRAPERITONEAL; MALE; METHYLAZOXYMETHANOL ACETATE; MOUTH; MOVEMENT; PHYSICAL STIMULATION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; TERATOGENS;

CITRUS LIMON;

EID: 4143115611     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2004.06.003     Document Type: Article

References (53)

1. Balduini W., Lombardelli G., Peruzzi G., Cattabeni F. Treatment with methylazoxymethanol at different gestational days: physical, reflex development and spontaneous activity in the offspring. Neurotoxicology. 12:1991;179-188
2. Bekoff A. Development of motor behavior in chick embryos. Lecanuet J.-P., Fifer W.P., Krasnegor N.A., Smotherman W.P. Fetal Development: A Psychobiological Perspective. 1995;191-204 Lawrence Erlbaum Associates, Hillsdale
3. Esclaire F., Kisby G., Spencer P., Milne J., Lesort M., Hugon J. The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity. Exp. Neurol. 155:1999;11-21
4. Ferguson S.A., Holson R.R. Methylazoxymethanol-induced micrencephaly in the brown Norway strain: behavior and brain weight. Int. J. Dev. Neurosci. 15:1997;75-86
5. Gavin C.E., Kates B., Gerken L.A., Rodier P.M. Patterns of growth deficiency in rats exposed in utero to undernutrition, ethanol, or the neuroteratogen methylazoxymethanol (MAM). Teratology. 49:1994;113-121
6. Godfrey K.M., Barker D.J. Fetal programming and adult health. Public Health Nutr. 4:2001;611-624
7. Goldey E.S., O'Callaghan J.P., Stanton M.E., Barone S. Jr., Crofton K.M. Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury. Fundam. Appl. Toxicol. 23:1994;447-464
8. Hamburger V., Wenger E., Oppenheim R. Motility in the chick embryo in the absence of sensory input. J. Exp. Zool. 166:1966;133-160
9. Jones K.L., Smith D.W. Recognition of the fetal alcohol syndrome in early infancy. Lancet. 2:1973;999-1001
10. Kabat K., Buterbaugh G.G., Eccles C.U. Methylazoxymethanol as a developmental model of neurotoxicity. Neurobehav. Toxicol. Teratol. 7:1985;519-525
11. Kisby G.E., Kabel H., Hugon J., Spencer P. Damage and repair of nerve cell DNA in toxic stress. Drug Metab. Rev. 31:1999;589-618
12. Kleven G.A., Queral L., Robinson S.R. Fetal patterns of interlimb movement synchrony, facial wiping, and nipple attachment are altered by prenatal exposure to methylazoxymethanol (MAM). Dev. Psychobiol. 41:2002;83
13. Kleven G.A., Queral L., Robinson S.R. Utility of fetal movement coordination in assessing nervous system functioning after prenatal administration of the neurotoxin methylazoxymethanol (MAM). Neurotoxicol. Teratol. 25:2003;395
14. Lacquer G.L. Oncogenicity of cycads and its implications. Kraybill H.F., Mehlman M.A. Advances in Modern Toxicology. vol. 3:1977;231-262 Wiley, New York
15. Matsumoto H., Higa H.H. Studies on methylazoxymethanol, the aglycone of cycasin: methylation of nucleic acids in vitro. Biochem. J. 98:1966;20C-22C
16. Matsumoto H., Spatz M., Laqueur G.L. Quantitative changes with age in the DNA content of methylazoxymethanol-induced microencephalic rat brain. J. Neurochem. 19:1972;297-306
17. Moessinger A.C. Fetal akinesia deformation sequence: an animal model. Pediatrics. 72:1983;857-863
18. Moessinger A.C. Morphological consequences of depressed or impaired fetal activity. Smotherman W.P., Robinson S.R. Behavior of the Fetus. 1988;163-173 Telford Press, Caldwell, NJ
19. Morgane P.J., Austin-LaFrance R., Bronzino J., Tonkiss J., Diaz-Cintra S., Cintra L., Kemper T., Galler J.R. Prenatal malnutrition and development of the brain. Neurosci. Biobehav. Rev. 17:1993;91-128
20. Nagata Y., Matsumoto H. Studies on methylazoxymethanol: methylation of nucleic acids in the fetal rat brain. Proc. Soc. Exp. Biol. Med. 132:1969;383-385
21. National Institutes of Health Guide for the Care and Use of Laboratory Animals. 1986;U.S. Government Printing Office, Washington, DC. Vol. DHEW Publication No. 86-23
22. Petry C.J., Hales C.N. Long-term effects on offspring of intrauterine exposure to deficits in nutrition. Hum. Reprod. Updat. 6:2000;578-586
23. Plonsky M., Riley E.P., Lee M.H., Haddad R.K. The effects of prenatal methylazoxymethanol acetate (MAM) on holeboard exploration and shuttle avoidance performance in rats. Neurobehav. Toxicol. Teratol. 7:1985;221-226
24. Prechtl H.F., Einspieler C. Is neurological assessment of the fetus possible? Eur. J. Obstet., Gynecol., Reprod. Biol. 75:1997;81-84
25. Queral L., Kleven G.A., Robinson S.R. Prenatal exposure to methylazoxymethanol (MAM) alters coordination in facial wiping and oral grasping responses of fetal rats. Annual Meeting of the Society for Neuroscience. vol. 27:2001;Society for Neuroscience Abstracts, San Diego, CA. program number 618.22
26. Reuhl K.R. Delayed expression of neurotoxicity: the problem of silent damage. Neurotoxicology. 12:1991;341-346
27. Ripley K.L., Provine R.R. Neural correlates of embryonic motility in the chick. Brain Res. 45:1972;127-134
28. Robinson S.R. A Comparative Study of Prenatal Behavioral Ontogeny in Altricial and Precocial Murid Rodents. 1989;Oregon State University, Corvallis
29. Robinson S.R., Smotherman W.P. The amniotic sac as scaffolding: prenatal ontogeny of an action pattern. Dev. Psychobiol. 24:1991;463-485
30. Robinson S.R., Smotherman W.P. Fundamental motor patterns of the mammalian fetus. J. Neurobiol. 23:1992;1574-1600
31. Robinson S.R., Smotherman W.P. Motor competition in the prenatal ontogeny of species-typical behavior. Anim. Behav. 44:1992;89-99
32. Robinson S.R., Hoeltzel T.C., Cooke K.M., Umphress S.M., Smotherman W.P., Murrish D.E. Oral capture and grasping of an artificial nipple by rat fetuses. Dev. Psychobiol. 25:1992;543-555
33. Robinson S.R., Arnold H.M., Spear N.E., Smotherman W.P. Experience with milk and an artificial nipple promotes conditioned opioid activity in the rat fetus. Dev. Psychobiol. 26:1993;375-387
34. Robinson S.R., Hoeltzel T.C.M., Smotherman W.P. Development of responses to an artificial nipple in the rat fetus: involvement of mu and kappa opioid systems. Physiol. Behav. 57:1995;953-957
35. Rodier P.M. Behavioral effects of antimitotic agents administered during neurogenesis. Riley E.P., Vorhees C.V. Handbook of Behavioral Teratology. 1986;185-209 Plenum Press, New York
36. Rodier P.M. The early origins of autism. Sci. Am. 282:2000;56-63
37. Schulte F.J., Schrempf G., Hinze G. Maternal toxemia, fetal malnutrition, and motor behavior of the newborn. Pediatrics. 48:1971;871-882
38. Simonik D.K., Robinson S.R., Smotherman W.P. Cocaine alters behavior in the rat fetus. Behav. Neurosci. 107:1993;867-875
39. Simonik D.K., Robinson S.R., Smotherman W.P. Central administration of cocaine produces age-dependent effects on behavior in the fetal rat. Behav. Neurosci. 108:1994;1179-1187
40. Simonik D.K., Robinson S.R., Smotherman W.P. Cocaine alters cyclic motor activity in the fetal rat. Dev. Psychobiol. 27:1994;489-501
41. Smotherman W.P., Robinson S.R. Environmental determinants of behaviour in the rat fetus. Anim. Behav. 34:1986;1859-1873
42. Smotherman W.P., Robinson S.R. Prenatal expression of species-typical action patterns in the rat fetus (Rattus norvegicus). J. Comp. Psychol. 101:1987;190-196
43. Smotherman W.P., Robinson S.R. Behavior of rat fetuses following chemical or tactile stimulation. Behav. Neurosci. 102:1988;24-34
44. Smotherman W.P., Robinson S.R. Cryptopsychobiology: the appearance, disappearance, and reappearance of a species-typical action pattern during early development. Behav. Neurosci. 103:1989;246-253
45. Smotherman W.P., Robinson S.R. Olfactory bulb transection alters fetal behavior after chemosensory but not tactile stimulation. Brain Res. Dev. Brain Res. 57:1990;175-180
46. Smotherman W.P., Robinson S.R. Accessibility of the rat fetus for psychobiological investigation. Shair H.N., Barr G.A., Hofer M.A. Developmental Psychobiology: New Methods and Changing Concepts. 1991;148-163 Oxford University Press, New York
47. Smotherman W.P., Arnold H.M., Robinson S.R. Responses to ecologically relevant stimuli in the rat fetus: interactive effects of milk and an artificial nipple. Dev. Psychobiol. 26:1993;359-374
48. Spatz M., Dougherty W.J., Smith D.W. Teratogenic effects of methylazoxymethanol. Proc. Soc. Exp. Biol. Med. 124:1967;476-478
49. Spencer P.S. Are neurotoxins driving us crazy? Planetary observations on the causes of neurodegenerative diseases of old age. Russell R.W., Flattau P.E., Pope A.M. Behavioral Measures of Neurotoxicity: Report of a Symposium. 1990;11-36 National Academy Press, Washington, DC
50. Spencer P.S., Kisby G.E., Ross S.M., Roy D.N., Hugon J., Ludolph A.C., Nunn P.B. Guam ALS-PDC: possible causes [letter; comment]. Science. 262:1993;825-826
51. Streissguth A.P., Landesman-Dwyer S., Martin J.C., Smith D.W. Teratogenic effects of alcohol in humans and laboratory animals. Science. 209:1980;353-361
52. Vorhees C.V., Fernandez K., Dumas R.M., Haddad R.K. Pervasive hyperactivity and long-term learning impairments in rats with induced micrencephaly from prenatal exposure to methylazoxymethanol. Brain Res. 317:1984;1-10
53. Whiting M.G. Toxicity of cycads. Econ. Bot. 17:1963;269-302