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Mediators and moderators of treatment effects in randomized controlled trials
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Kraemer H, Wilson G, Fairburn C, Agras W. Mediators and moderators of treatment effects in randomized controlled trials. Arch Gen Psychiatry 2002; 59:877-883. This is an important review of an analytic framework to recognize and distinguish between mediators and moderators so that most effective treatments and most likely responders can be identified.
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Arch Gen Psychiatry
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Kraemer, H.1
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Cognitive behaviour therapy for depression? Choose horses for courses
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Parker G, Roy K, Eyers K. Cognitive behaviour therapy for depression? Choose horses for courses. Am J Psychiatry 2003; 160:825-834. This is an excellent critique of the strengths and weaknesses of current empirical data on the role of cognitive therapy in the treatment of depression. It includes suggestions of key areas for future research.
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Am J Psychiatry
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Parker, G.1
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Methodological aspects of randomized controlled trials of psychotherapy in primary care
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Scott J, Sensky T. Methodological aspects of randomized controlled trials of psychotherapy in primary care. Psychological Medicine 2003; 33:191-196. This is a useful overview of the problems of undertaking RCTs of brief therapies.
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Psychological Medicine
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Scott, J.1
Sensky, T.2
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Group interpersonal psychotherapy for depression in rural Uganda: A randomized controlled trial
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Bolton P, Bass J, Neugebauer R, et al. Group interpersonal psychotherapy for depression in rural Uganda: a randomized controlled trial. JAMA 2003; 289:3117-3124. This is an important paper because it explores the use of brief therapies in different ethnic and cultural contexts.
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JAMA
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Bolton, P.1
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Treating depression in predominantly low-income young minority women: A randomized controlled trial
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Miranda J, Chung JY, Green BL, et al. Treating depression in predominantly low-income young minority women: a randomized controlled trial. JAMA 2003; 290:57-65. Women with MDD from impoverished backgrounds, where ethnic minority subgroups are over-represented responded well to ADM or CT and both treatments were superior to routine referral to community services. This RCT is important because it demonstrates that CT can be delivered to different socioeconomic, cultural and ethnic groups without any significant loss in efficacy.
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JAMA
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Miranda, J.1
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Improving care for minorities: Can quality improvement interventions improve care and outcomes for depressed minorities? Results of a randomized, controlled trial
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Miranda J, Duan N, Sherbourne C, et al. Improving care for minorities: can quality improvement interventions improve care and outcomes for depressed minorities? Results of a randomized, controlled trial. Health Services Research 2003; 38:613-630. An important re-analysis of data from a large multi-centre RCT. It suggests that the observed reductions in depressive symptoms were primarily a result of the significant gains made by individuals from ethnic minority rather than Caucasian subgroups. The latter benefited much less from systematic care or CT, but interestingly still had better employment outcomes.
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Health Services Research
, vol.38
, pp. 613-630
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Miranda, J.1
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7
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Treating depression in primary care in low-income women in Santiago, Chile: A randomized controlled trial
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Araya R, Rojas G, Fritsch R, et al. Treating depression in primary care in low-income women in Santiago, Chile: a randomized controlled trial. Lancet 2003; 361:995-1000. This RCT that moved away from the traditional settings and populations usually involved in treatment trials of depression. The paper is additionally interesting as the therapy comprises a brief psycho-education package.
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Lancet
, vol.361
, pp. 995-1000
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Araya, R.1
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A randomized controlled trial of an educational intervention for depression among Asian women in primary care in the United Kingdom
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Jacobs K, Bhugra D, Mann A. A randomized controlled trial of an educational intervention for depression among Asian women in primary care in the United Kingdom. Int J Soc Psychiatry 2002; 48:139-148.
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Jacobs, K.1
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9
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A randomized controlled trial to evaluate the effectiveness and cost-effectiveness of psychodynamic counselling for general practice patients with chronic depression
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Simpson S, Corney R, Fitzgerald P, Beecham J. A randomized controlled trial to evaluate the effectiveness and cost-effectiveness of psychodynamic counselling for general practice patients with chronic depression. Psychol Med 2003; 33:229-239.
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Simpson, S.1
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Scott J. Cognitive therapy for depression. Br Med Bull 2001; 57:101-113.
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Scott, J.1
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A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents
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Clarke GN, Hornbrook M, Lynch F, et al. A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Archives of General Psychiatry 2001; 58:1127-1134.
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Archives of General Psychiatry
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Clarke, G.N.1
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12
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Controlled clinical trial of interpersonal psychotherapy versus parenting education program for depressed pregnant women
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Spinelli M, Endicott J. Controlled clinical trial of interpersonal psychotherapy versus parenting education program for depressed pregnant women. Am J Psychiatry 2003; 160:555-562.
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Am J Psychiatry
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Chabrol H, Teissedre F, St-Jean M, et al. Prevention and treatment of postpartum depression: a controlled randomized study on women at risk. Psychol Med 2002; 32:1039-1047.
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Chabrol, H.1
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Burnand Y, Andreoli A, Kolatte E, et al. Psychodynamic psychotherapy and clomipramine in the treatment of major depression. Psychiatr Serv 2002; 53:585-590.
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Burnand, Y.1
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Sertraline and/or interpersonal psychotherapy for patients with dysthymic disorder in primary care: Six month comparison with longitudinal two year follow-up of effectiveness and costs
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Browne G, Steiner M, Roberts J, et al. Sertraline and/or interpersonal psychotherapy for patients with dysthymic disorder in primary care: six month comparison with longitudinal two year follow-up of effectiveness and costs. J Affect Disord 2002; 68:317-330.
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Use of cognitive therapy for relapse prevention in chronic depression. Cost-effectiveness study
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Scott J, Palmer S, Paykel E, et al. Use of cognitive therapy for relapse prevention in chronic depression. Cost-effectiveness study. Br J Psychiatry 2003; 182:221-227. This is one of the few cost-effectiveness studies of an RCT of psychological treatments that also explores the longer term outcomes and cost per depressive relapse.
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Br J Psychiatry
, vol.182
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Scott, J.1
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Miller P, Chilvers C, Dewey M, et al. Counseling versus antidepressant therapy for the treatment of mild to moderate depression in primary care: economic analysis. Int J Technol Assess Health Care 2003; 19:80-90.
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Schulberg H, Raue P, Rollman B. The effectiveness of psychotherapy in treating depressive disorders in primary care practice: clinical and cost perspectives. Gen Hosp Psychiatry 2002; 24:203-212.
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King M, Davidson O, Taylor F, et al. Effectiveness of teaching general practitioners skills in brief cognitive behaviour therapy to treat patients with depression: randomised controlled trial. BMJ 2002; 324:947-950. This important paper suggests that training general practitioners in the use of techniques is unlikely to develop into an effective treatment strategy.
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BMJ
, vol.324
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King, M.1
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Computerized, interactive, multimedia cognitive behavioural program for anxiety and depression in general practice
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Proudfoot J, Goldberg D, Mann A, et al. Computerized, interactive, multimedia cognitive behavioural program for anxiety and depression in general practice. Psychol Med 2003; 33:191-196.
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Clarke G, Reid E, Eubanks D, et al. Overcoming depression on the internet: randomized controlled trial of an internet depression skills intervention program. J Med Internet Res 2002; 4:E14.
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Miller L, Weissman M. Interpersonal psychotherapy delivered over the telephone to recurrent depressives. A pilot study. Depress Anxiety 2002; 16:114-117.
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Meyer B, Krupnick JL, Simmens SJ, et al. Treatment expectancies, patient alliance, and outcome: further analyses from the NIMH TDCRP. J Consult Clin Psychol 2002; 70:1051-1055.
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Hamilton K, Dobson K. Cognitive therapy of depression: pre-treatment patient predictors of outcome. Clin Psychol Rev 2002; 22:875-893.
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Shahar G, Blatt SJ, Zuroff DC, Pilkonis PA. Role of perfectionism and personality disorder features in response to brief treatment for depression. J Consult Clin Psychol 2003; 71:629-633.
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Zuroff DC, Blatt SJ, Sotsky SM, et al. Relation of therapeutic alliance and perfectionism to outcome in brief outpatient treatment for depression. J Consult Clin Psychol 2000; 68:114-124.
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Tang TZ, Luborsky L, Andrusyna T. Sudden gains in recovering from depression: are they also found in psychotherapies other than cognitive-behavioural therapy? J Consult Clin Psychol 2002; 70:444-447. This fascinating research suggests that a significant reduction in symptoms between two sessions of therapy may be the best predictor of outcome in MDD. This has important implications for monitoring of progress and the development of all brief therapies.
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J Consult Clin Psychol
, vol.70
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Tang, T.Z.1
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Teasdale JD, Moore RG, Hayhurst H, et al. Metacognitive awareness and prevention of relapse in depression: Empirical evidence. J Consult Clin Psychol 2002; 70:275-287. This was an important study of the mechanisms of action of cognitive therapy that offers some support for the compensatory skills hypothesis.
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Segal Z, Vincent P, Levitt A. Efficacy of combined, sequential, and crossover psychotherapy and psychotherapy in improving outcomes in depression. J Psychiatry Neurosci 2002; 27:281-290.
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Wampold BE, Minami T, Baskin TW, Callen Tierney S. A meta-(re)analysis of the effects of cognitive therapy versus 'other therapies' for depression. J Affect Disord 2002; 68:159-165. This carefully conducted meta-analysis controlled for therapist training, quality of therapies and other methodological problems. The authors demonstrate that when all these factors are taken into account all brief therapies have a similar level of effectiveness.
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J Affect Disord
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Merrill KA, Tolbert VE, Wade WA. Effectiveness of cognitive therapy for depression in a community mental health center: a benchmarking study. J Consult Clin Psychol 2003; 71:404-409.
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J Consult Clin Psychol
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