Dilution of rocuronium to 0.5 mg/mL with 0.9% NaCl eliminates the pain during intravenous injection in awake patients

Anesthesia and Analgesia

Volumn 99, Issue 3, 2004, Pages 740-743

  Tuncali, Bahattin ^a,b   Karci, Ayse ^a   Tuncali, Binnur Erdalkiran ^a   Mavioglu, Omur ^a   Olguner, Cimen Gulben ^a   Ayhan, Selin ^a   Elar, Zahide ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ROCURONIUM; SODIUM CHLORIDE; SUXAMETHONIUM;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DEMOGRAPHY; DILUTION; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; FEMALE; HUMAN; INJECTION PAIN; MAJOR CLINICAL STUDY; MALE; OSMOLALITY; PAIN; PAIN ASSESSMENT; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; WAKEFULNESS;

ADULT; AGED; ANDROSTANOLS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NEUROMUSCULAR NONDEPOLARIZING AGENTS; OSMOLAR CONCENTRATION; PAIN; SODIUM CHLORIDE; WAKEFULNESS;

EID: 4143103747     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000130005.94395.B2     Document Type: Article

References (18)

1. Savarese JJ, Caldwell JE, Lien CA, Miller RD. Pharmacology of muscle relaxants and their antagonists. In: Miller RD, ed. Anesthesia. Philadelphia: Churchill Livingstone, 2000:412-90.
2. Martin R, Carrier J, Pirlet M, et al. Rocuronium is the best non-depolarizing relaxant to prevent succinylcholine fasciculations and myalgia. Can J Anaesth 1998;45:521-5.
3. Moorthy SS, Dierdorf SF. Pain on injection of rocuronium bromide. Anesth Analg 1995;80:1067.
4. Lockey D, Coleman P. Pain during injection of rocuronium bromide. Anaesthesia 1995;50:474.
5. Steegers MA, Robertson EN. Pain on injection of rocuronium bromide. Anesth Analg 1996;83:193-205.
6. Borgeat A, Kwiatkowski D. Spontaneous movements associated with rocuronium: is pain on injection the cause? Br J Anaesth 1997;79:382-3.
7. Joshi GP, Whitten CW. Pain on injection of rocuronium bromide. Anesth Analg 1997;84:228-36.
8. Ruetsch YA, Borgeat A. Withdrawal movements associated with the injection of rocuronium. Anesth Analg 2000;90:227-8.
9. Shevchenko Y, Jocson JC, McRae VA, et al. The use of lidocaine for preventing the withdrawal associated with the injection of rocuronium in children and adolescents. Anesth Analg 1999;88: 7446-8.
10. Cheong KF, Wong WH. Pain on injection of rocuronium: influence of two doses of lidocaine pretreatment. Br J Anaesth 2000; 84:106-7.
11. Reddy MS, Chen FG, Ng HP. Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. Anaesthesia 2001;56:879-905.
12. Memis D, Turan A, Karamanlioglu B, et al. The prevention of pain from injection of rocuronium by ondansetron, lidocaine, tramadol and fentanyl. Anesth Analg 2002;94:1517-20.
13. Memis D, Turan A, Karamanlioglu B, et al. The prevention of pain from injection of rocuronium by magnesium sulphate, lignocaine, sodium bicarbonate and alfentanil. Anaesth Intensive Care 2003;31:277-81.
14. Dalgleish DJ. Drugs which cause pain on intravenous injection. Anaesthesia 2000;55:828-9.
15. Chiarella AB, Jolly DT, Huston CM, et al. Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium. Br J Anaesth 2003;90:377-9.
16. Arndt JO, Klement W. Pain evoked by polymodal stimulation of hand veins in humans. J Physiol 1991;440:467-78.
17. Tan CH, Onsiong MK. Pain on injection of propofol. Anaesthesia 1998;53:468-76.
18. Klement W, Arndt JO. Pain on intravenous injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations. Br J Anaesth 1991;66:189-95.