Kinetics of immune parameters in a patient with sepsis caused by Streptococcus pyogenes treated with activated protein C

Scandinavian Journal of Infectious Diseases

Volumn 36, Issue 6-7, 2004, Pages 486-488

  Holub, Michal ^a,b   Helcl, Miroslav ^b   Beran, Ondřej ^a,c   Hnyková, Jarmila ^a   Příhodová, Jana ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL BULOVKA   (Czech Republic)

^c WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTIBIOTIC AGENT; CD4 ANTIGEN; CD8 ANTIGEN; CEFALOTIN; DROTRECOGIN; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; NORADRENALIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BACTERIUM IDENTIFICATION; BLEEDING; BLOOD SAMPLING; CASE REPORT; CHILL; CLINICAL OBSERVATION; FEMALE; FEVER; FLOW CYTOMETRY; HEMODIALYSIS; HOSPITAL ADMISSION; HUMAN; HYDRATION; IMMUNOLOGICAL PARAMETERS; IMMUNOMODULATION; INTENSIVE CARE UNIT; KIDNEY FAILURE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MYALGIA; PATHOGENESIS; RESPIRATORY FAILURE; RESPIRATORY TRACT INTUBATION; SEPSIS; SHOCK; STREPTOCOCCUS PYOGENES; TREATMENT OUTCOME;

EID: 4143100265     PISSN: 00365548     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365540410016113     Document Type: Article

References (14)

1. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
2. Groeneveld AB, Tacx AN, Bossink AW, van Mierlo GJ, Hack CE. Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection. Clin Immunol 2003; 106: 106-15.
3. Reddy RC, Chen GH, Tekchandani PK, Standiford TJ. Sepsis-induced immunosuppression. Immunol Res 2001; 24: 273-87.
4. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250-6.
5. Moreno R, Vincent JL, Matos R, Mendonca A, Cantraine F, Thijs L, et al. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of prospective, multicentre study. Working group on sepsis related problems of the ESCIM. Intensive Care Med 1999; 25: 686-96.
6. Cheadle WG, Pemberton RM, Robinson D, Livingston DH, Rodriguez JL, Polk HC Jr. Lymphocyte subset responses to trauma and sepsis. J Trauma 1993; 35: 844-9.
7. Holub M, Kluckova Z, Helcl M, Prihodova J, Rokyta R, Beran O. Lymphocyte subset numbers depend on the bacterial origin of sepsis. Clin Microbiol Infect 2003; 9: 202-11.
8. + T-lymphocytes in humans. J Immunol 2001; 166: 6952-63.
9. Grinnell BW, Hermann RB, Yan SB. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology 1994; 4: 221-5.
10. Joyce DE, Grinnel BW. Recombinant human activated protein C attenuates the inflammatory responses in endothelium and monocytes by modulating nuclear factor-κB. Crit Care Med 2002; 30(Suppl 5): S288-93.
11. Yu DT, Clements PJ, Paulus HE, Peter JB, Levy J, Barnett EV. Human lymphocyte subpopulations. Effect of corticosteroids. J Clin Invest 1974; 53: 565-71.
12. Dellinger RP. Inflammation and coagulation: implications for the septic patient. Clin Infect Dis 2003; 36: 1259-65.
13. Rahman A, Anwar KN, True AL, Malik AB. Thrombin-induced p65 homodimer binding to downstream NF-κB site of the promoter mediated endothelial ICAM-1 expression and neutrophil adhesion. J Immunol 1999; 162: 5466-76.
14. Stevens DL, Bryant AE, Hackett SP, Chang A, Peer G, Kosanke S. Group A streptococcal bacteraemia: the role of tumour necrosis factor in shock and organ failure. J Infect Dis 1996; 173: 619-26.