Sensory testing of the esophagus

Journal of Clinical Gastroenterology

Volumn 38, Issue 8, 2004, Pages 628-641

  Fass, Ronnie ^a,b  

^a SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Brain imaging; Esophageal sensation; Esophagus; Provocative testing

Indexed keywords

EDROPHONIUM; PROTON PUMP INHIBITOR;

BALLOON; COMPUTER ANALYSIS; ECHOGRAPHY; ELECTROSTIMULATION; ESOPHAGUS FUNCTION; EVALUATION; HUMAN; IMPEDANCE; PAIN ASSESSMENT; PERCEPTIVE THRESHOLD; PERFUSION; PRIORITY JOURNAL; REVIEW; SENSORY STIMULATION;

ACIDS; BALLOON DILATATION; BRAIN; CHOLINESTERASE INHIBITORS; EDROPHONIUM; ELECTRIC IMPEDANCE; ELECTRIC STIMULATION; ESOPHAGUS; EVOKED POTENTIALS; HUMANS; PROTON PUMPS; SENSATION;

EID: 4143061302     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mcg.0000128989.13808.95     Document Type: Review

References (147)

1. Gebhart GF. Visceral pain-peripheral sensitisation. Gut. 2000;47: iv54-iv55; discussion iv58.
2. Goyal RK, Hirano I. The enteric nervous system. N Engl J Med. 1996;334:1106-1115.
3. Grundy D, Scratcherd T. Sensory afferents from the gastrointestinal tract. In: Schultz SG, Wood JD, Rauner BB, eds. Handbook of Physiology. New York: Oxford University; 1989:593-620.
4. Randich A. Visceral nerve stimulation and pain modulation. In: Joshn LR, ed. Physiology of the Gastrointestinal Tract. 3rd ed. Amsterdam: Elsevier; 1993:126-139.
5. Tougas G, Fitzpatrick D, Upton ARM, et al. The cortical evoked responses produced by balloon distention and electrical stimulation of the esophagus involve different vagal fibers. Gastroenterology. 1993;104.
6. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology. 1994;107:271-293.
7. Fass R, Naliboff B, Higa L, et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology. 1998;115:1363-1373.
8. Rodrigo J, Hernandez CJ, Vidal MA, et al. Vegetative innervation of the esophagus. III. Intraepithelial endings. Acta Anat (Basel). 1975;92:242-258.
9. Fass R, Tougas G. Functional heartburn - the stimulus, the pain and the brain. Gut. 2002;51:885-892.
10. Aziz Q, Andersson JL, Valind S, et al. Identification of human brain loci processing esophageal sensation using positron emission tomography. Gastroenterology. 1997;113:50-59.
11. Minshohima S, Morrow TJ, Koeppe RA. Involvement of insular cortex in central autonomic regulation during painful thermal stimulation. J Cereb Blood Flow Metab. 1995;15:1355-1358.
12. Talbot JD, Marrett S, Evans AC, et al. Multiple representations of pain in human cerebral cortex. Science. 1991;251:1355-1358.
13. Vogt BA, Sikes RW, Vogt LJ. Anterior cingulate cortex and the medial pain system. In: Vogt BA, Gabriel M, eds. Neurobiology of Cingulate Cortex and Limbic Thalamus. Boston: Birkhauser; 1994:313-344.
14. Kern MK, Birn RM, Jaradeh S, et al. Identification and characterization of cerebral cortical response to esophageal mucosal acid exposure and distention. Gastroenterology. 1998;115:1353-1362.
15. Takeda T, Liu J, Gui A, et al. Heartburn not chest pain, is the most common symptoms in response to esophageal distension in normal subjects. Gastroenterology. 2001;120:A-222.
16. Balaban DH, Yamamoto Y, Liu J, et al. Sustained esophageal contraction: a marker of esophageal chest pain identified by intraluminal ultrasonography. Gastroenterology. 1999;116:29-37.
17. Pehlivanov N, Liu J, Mittal RK. Sustained esophageal contraction: a motor correlate of heartburn symptom. Am J Physiol Gastrointest Liver Physiol. 2001;281:G743-G751.
18. Baldi F, Ferrarini F, Longanesi A, et al. Acid gastroesophageal reflux and symptom occurrence. Analysis of some factors influencing their association. Dig Dis Sci. 1989;34:1890-1893.
19. Meyer JH, Lembo A, Elashoff JD, et al. Duodenal fat intensifies the perception of heartburn. Gut. 2001;49:624-628.
20. Fass R. Focused clinical review - nonerosive reflux disease. Medscape Gastroenterol. 2001;3:1-13.
21. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastrooesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut. 1995;37:7-12.
22. Fass R, Malagon I, Naliboff B, et al. Effect of psychologically induced stress on symptom perception & autonomic nervous system response of patients (PTS) with erosive esophagitis (EE) and non-erosive reflux disease (NERD). Gastroenterology. 2000;118:A637.
23. Fass R, Malagon I, Pulliam G, et al. Gender differences in perceptual and emotional ratings of intra-esophageal stimuli in GERD patients undergoing auditory-induced stress. Gastroenterology. 2002;122:A187.
24. Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47:861-869.
25. Bernstein LM, Baker LA. A clinical test for esophagitis. Gastroenterology. 1958;347:760.
26. Bemot R, Norton RA. The esophageal acid perfusion test. Lahey Clin Found Bull. 1965;14:58-63.
27. Richter JE, Hewson EG, Sinclair JW, et al. Acid perfusion test and 24-hour esophageal pH monitoring with symptom index. Comparison of tests for esophageal acid sensitivity. Dig Dis Sci. 1991;36:565-571.
28. Price SF, Smithson KW, Castell DO. Food sensitivity in reflux esophagitis. Gastroenterology. 1978;75:240-243.
29. Kaul B, Petersen H, Grette K, et al. The acid perfusion test in gastroesophageal reflux disease. Scand J Gastroenterol. 1986;21:93-96.
30. Howard PJ, Maher L, Pryde A, et al. Symptomatic gastro-oesophageal reflux, abnormal oesophageal acid exposure, and mucosal acid sensitivity are three separate, though related, aspects of gastro-oesophageal reflux disease. Gut. 1991;32:128-132.
31. Battle WS, Nyhus LM, Bombeck CT. Gastroesophageal reflux: diagnosis and treatment. Ann Surg. 1973;177:560-565.
32. Behar J, Biancani P, Sheahan DG. Evaluation of esophageal tests in the diagnosis of reflux esophagitis. Gastroenterology. 1976;71:9-15.
33. Breen KJ, Whelan G. The diagnosis of reflux oesophagitis: an evaluation of five investigative procedures. Aust N Z J Surg. 1978;48:156-161.
34. Fisher RS, Cohen S. Gastroesophageal reflux. Med Clin North Am. 1978;62:3-20.
35. Bachir GS, Leigh-Collis J, Wilson P, et al. Diagnosis of incipient reflux esophagitis: a new test. South Med J. 1981;74:1072-1074.
36. Johnson DA, Winters C, Spurling TJ, et al. Esophageal acid sensitivity in Barrett's esophagus. J Clin Gastroenterol. 1987;9:23-27.
37. Gracely RH, McGrath F, Dubner R. Ratio scales of sensory and affective verbal pain descriptors. Pain. 1978;5:5-18.
38. Silverman DH, Munakata JA, Ennes H, et al. Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology. 1997;112:64-72.
39. Richter JE. Provocative tests in esophageal diseases. In: Scarpignato C, Galmiche JP, eds. Functional Evaluation in Esophageal Disease. Basel: Karger; 1994.
40. De Caestecker JS, Pryde A, Heading RC. Comparison of intravenous edrophonium and oesophageal acid perfusion during oesophageal manometry in patients with non-cardiac chest pain. Gut. 1988;29:1029-1034.
41. Ghillebert G, Janssens J, Vantrappen G, et al. Ambulatory 24 hour intraoesophageal pH and pressure recordings v provocation tests in the diagnosis of chest pain of oesophageal origin. Gut. 1990;31:738-744.
42. Hewson EG, Dalton CB, Richter JE. Comparison of esophageal manometry, provocative testing, and ambulatory monitoring in patients with unexplained chest pain. Dig Dis Sci. 1990;35:302-309.
43. Nevens F, Janssens J, Piessens J, et al. Prospective study on prevalence of esophageal chest pain in patients referred on an elective basis to a cardiac unit for suspected myocardial ischemia. Dig Dis Sci. 1991;36:229-235.
44. Peters L, Maas L, Petty D, et al. Spontaneous noncardiac chest pain. Evaluation of 24-hour ambulatory esophageal motility and pH monitoring. Gastroenterology. 1988;94:878-886.
45. Soffer EE, Scalabrini P, Wingate DL. Spontaneous noncardiac chest pain: value of ambulatory esophageal pH and motility monitoring. Dig Dis Sci. 1989;34:1651-1655.
46. Vantrappen G, Janssens J, Ghillebert G. The irritable oesophagus - a frequent cause of angina-like pain. Lancet. 1987;1:1232-1234.
47. Hewson EG, Sinclair JW, Dalton CB, et al. Acid perfusion test: does it have a role in the assessment of non cardiac chest pain. Gut. 1989;30:305-310.
48. Eslick GD, Fass R. Non-cardiac chest pain: evaluation and treatment. Gastroenterol Clin N Am. 2003;32:531-552.
49. London RL, Ouyang A, Snape WJJ, et al. Provocation of esophageal pain by ergonovine or edrophonium. Gastroenterology. 1981;81:10-14.
50. Nostrant TT. Provocation testing in noncardiac chest pain. Chest pain of undetermined origin. Am J Gastroenterol. 1991;5A:S56-S64.
51. Richter JE, Hackshaw BT, Wu WC, et al. Edrophonium: a useful provocative test for oesophageal chest pain. Ann Intern Med. 1985;103:14-21.
52. Frobert O, Funch-Jensen P, Bagger JP. Diagnostic value of esophageal studies in patients with angina-like chest pain and normal coronary angiograms. Ann Intern Med. 1996;124:959-969.
53. Katz PO, Dalton CB, Richter JE, et al. Esophageal testing of patients with noncardiac chest pain or dysphagia. Ann Intern Med. 1987;106:593-597.
54. Cooke RA, Anggiansah A, Chambers JB, et al. A prospective study of oesophageal function in patients with normal coronary angiograms and controls with angina. Gut. 1998;42:323-329.
55. Dalton CB, Hewson EG, Castell DO, et al. Edrophonium provocative test in noncardiac chest pain. Evaluation of testing techniques. Dig Dis Sci. 1990;35:1445-1451.
56. DiMarino AJJ, Allen ML, Lynn RB, et al. Clinical value of esophageal motility testing. Dig Dis. 1998;16:198-204.
57. Richter JE, Bradley LA, Castell DO. Esophageal chest pain: current controversies in pathogenesis, diagnosis, and therapy. Ann Intern Med. 1989;110:66-78.
58. Benjamin SB, Richter JE, Cordova CM, et al. Prospective manometric evaluation with pharmacologic provocation of patients with suspected esophageal motility dysfunction. Gastroenterology. 1983;84:893-901.
59. Mellow M. Symptomatic diffuse esophageal spasm. Manometric follow-up and response to cholinergic stimulating and cholinesterase inhibition. Gastroenterology. 1977;73:237-240.
60. Nostrant TT, Sams J, Huber T. Bethanechol increases the diagnostic yield in patients with esophageal chest pain. Gastroenterology. 1986;91:1141-1146.
61. Davies HA, Kaye MD, Rhodes J, et al. Diagnosis of oesophageal spasm by ergometrine provocation. Gut. 1982;23:89-97.
62. Buxton A, Goldberg S, Hirshfeld JW, et al. Refractory ergonovine-induced coronary vasospasm: importance of intracoronary nitroglycerin. Am J Cardiol. 1980;46:329-334.
63. Cherian P, Smith LF, Bardhan KD, et al. Esophageal tests in the evaluation of non-cardiac chest pain. Dis Esophagus. 1995;8:129-133.
64. Fass R, Fennerty MB, Ofman JJ, et al. The clinical and economic value of a short course of omeprazole in patients with noncardiac chest pain. Gastroenterology. 1998;115:42-49.
65. Hsia PC, Maher KA, Lewis JH, et al. Utility of upper endoscopy in the evaluation of noncardiac chest pain. Gastrointest Endosc. 1991;37:22-26.
66. Frobert O, Funch-Jensen P, Jacobsen NO, et al. Upper endoscopy in patients with angina and normal coronary angiograms. Endoscopy. 1995;27:365-370.
67. Locke GR 3rd, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmstead County. Minnesota. Gastroenterology. 1997;112:1448-1456.
68. Hewson EG, Sinclair JW, Dalton CB, et al. Twenty-four-hour esophageal pH monitoring: the most useful test for evaluating noncardiac chest pain. Am J Med. 1991;90:576-583.
69. Achem SR, Kolts BE, MacMath T, et al. Effects of omeprazole versus placebo in treatment of noncardiac chest pain and gastroesophageal reflux. Dig Dis Sci. 1997;42:2138-2145.
70. Fass R, Fennerty MB, Vakil N. Nonerosive reflux disease - current concepts and dilemmas. Am J Gastroenterol. 2001;96:303-314.
71. Fass R, Winters GF. Evaluation of the patient with noncardiac chest pain: is gastroesophageal reflux disease or an esophageal motility disorder the cause? Medscape Gastroenterol eJournal. 2001;3:1-7.
72. Euler AR, Byrne WJ. Twenty-four-hour esophageal intraluminal pH probe testing: comparative analysis. Gastroenterology. 1981;80:957-961.
73. Fass R. Empirical trials in treatment of gastroesophageal reflux disease. Dig Dis. 2000;18:20-26.
74. Fass R. Testing of diagnosis with a therapeutic trial: concept and requirements for a therapeutic trial. Eur J Gastroenterol Hepatol. 2001;13: S49-S50.
75. Schenk BE, Kuipers EJ, Klinkenberg-Knol EC, et al. Omeprazole as a diagnostic tool in gastroesophageal reflux disease. Am J Gastroenterol. 1997;92:1997-2000.
76. Squillace SJ, Young MF, Sanowski RA. Single dose omeprazole as a test for noncardiac chest pain. Gastroenterology. 1993;104:A197.
77. Young MF, Sanowski RA, Talbert GA, et al. Omeprazole administration as a test for gastroesophageal reflux. Gastroenterology. 1992;102:192.
78. Pandak WM, Arezo S, Everett S, et al. Short course of omeprazole. A better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour esophageal pH monitoring. J Clin Gastroenterol. 2002;35:307-314.
79. Fass R, Pulliam G, Hayden CW. Patients with non-cardiac chest pain (NCCP) receiving an empirical trial of high dose lansoprazole, demonstrate early symptom response-a double blind, placebo-controlled trial. Gastroenterology. 2001;120:A221.
80. Fass R, Fullerton H, Hayden CW, et al. Patients with noncardiac chest pain (NCCP) receiving an empirical trial of high dose rabeprazole, demonstrate early symptom response - a double blind, placebo-controlled trial. Gastroenterology. 2002;122:A580-A581.
81. Fass R, Fennerty MB, Johnson C, et al. Correlation of ambulatory 24-hour esophageal pH monitoring results with symptom improvement in patients with noncardiac chest pain due to gastroesophageal reflux disease. J Clin Gastroenterol. 1999;28:36-39.
82. Ofman J, Gralnek I, Udani J, et al. The cost-effectiveness of the omepra zole test in noncardiac chest pain (NCCP). Gastroenterology. 1998;114: A31.
83. Ofman JJ, Gralnek IM, Udani J, et al. The cost-effectiveness of the omeprazole test in patients with noncardiac chest pain. Am J Med. 1999;107:288-289.
84. Fass R, Ofman JJ, Sampliner RE, et al. The omeprazole test is as sensitive as 24-h oesophageal pH monitoring in diagnosing gastrooesophageal reflux disease in symptomatic patients with erosive esophagitis. Aliment Pharmacol Ther. 2000;14:389-396.
85. Hollerbach S, Kamath MV, Fitzpatrick D, et al. The cerebral response to electrical stimuli in the oesophagus is altered by increasing stimulus frequencies. Neurogastroenterol Motil. 1997;9:129-139.
86. Tougas G, Hudoba P, Fitzpatrick D, et al. Cerebral-evoked potential responses following direct vagal and esophageal electrical stimulation in humans. Am J Physiol. 1993;264:G486-G491.
87. Sarkar S, Aziz Q, Woolf CJ, et al. Contribution of central sensitisation to the development of noncardiac chest pain. Lancet. 2000;356:1154-1159.
88. Heft MW, Parker SR. An experimental basis for revising the graphic rating scale for pain. Pain. 1984;19:153-161.
89. Hollerbach S, Bulat R, May A, et al. Abnormal cerebral processing of oesophageal stimuli in patients with noncardiac chest pain (NCCP). Neurogastroenterol Motil. 2000;12:555-565.
90. Harris JH, Therkelsen EE, Zinner NR. Electrical measurement of urethral flow. In: Boyarsky S, Tanagho EA, Gottschalf CW, Zimskind PD, eds. Urodynamics. London: Academic Press; 1971:465-472.
91. Rask-Andersen H, Djurhuus JC. Development of a probe for endoureteral investigation of peristalsis by flow velocity and cross section area measurement. Acta Chir Scand Suppl. 1976;472:59-65.
92. Silny J, Knigge KP, Fass J, et al. Verification of the intraluminal multiple electrical impedance measurement for the recording of gastrointestinal motility. J Gastrointest Motil. 1993;5:107-122.
93. Rao SSC, Hayek B, Summers RW. Impedance planimetry: an integrated approach for assessing sensory, active, and passive biomechanical properties of the human esophagus. Am J Gastroenterol. 1995;90:431-438.
94. Orvar KB, Gregersen H, Christensen J. Biomechanical characteristics of the human esophagus. Dig Dis Sci. 1993;38:197-205.
95. Rao SSC, Hayek B, Summers RW. Functional chest pain of esophageal origin: hyperalgesia or motor dysfunction. Am J Gastroenterol. 2001;96:2584-2589.
96. Sifrim D, Holloway R, Silny J, et al. Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during ambulatory 24-hour pH-impedance recordings. Gastroenterology. 2001;120:1588-1598.
97. Vela MF, Camacho-Lobato L, Srinivasan R, et al. Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. Gastroenterology. 2001;120:1599-1606.
98. Silny J. Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility. J Gastrointest Motil. 1991;3:151-162.
99. Fass J, Silny J, Braun J, et al. Measuring esophageal motility with a new intraluminal impedance device. First clinical results in reflux patients. Scand J Gastroenterol. 1994;29:693-702.
100. Nguyen HN, Silny J, Matern S. Multiple intraluminal electrical impedancometry for recording of upper gastrointestinal motility: current results and further implications. Am J Gastroenterol. 1999;94:306-317.
101. Takeda T, Kassab G, Liu J, et al. A novel ultrasound technique to study the biomechanics of the human esophagus in vivo. Am J Physiol Gastrointest Liver Physiol. 2002;282:G785-G793.
102. Richter JE, Barish CF, Castell DO. Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology. 1986;91:845-852.
103. Ritchie J. Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut. 1973;14:125-132.
104. Mertz H, Walsh JH, Sytnik B, et al. The effect of octreotide on human gastric compliance and sensory perception. Neurogastroenterol Motil. 1995;7:175-185.
105. Kramer P, Hollander W. Comparison of experimental esophageal pain with clinical pain of angina pectoris and esophageal disease. Gastroenterology. 1955;29:719.
106. Lipkin M, Sleisenger MH. Studies of visceral pain: measurements of stimulus intensity and duration associated with the onset of pain in esophagus, ileum and colon. J Clin Invest. 1958;37:28.
107. Yakshe PN, et al. Does provocative esophageal testing influence coronary blood flow or coronary flow reserve? Preliminary results of concurrent esophageal and cardiac testing. Gastroenterology. 1993;104: A227.
108. Barish CF, Castell DO, Richter JE. Graded esophageal balloon distention. A new provocative test for noncardiac chest pain. Dig Dis Sci. 1986;31:1292-1298.
109. Whitehead WE, Delvaux M, Team TW. Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. Dig Dis Sci. 1997;42:223-241.
110. Azpiroz F, Malagelada JR. Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol. 1985;248: G229-G237.
111. Toma TD, Zighelboim J, Phillips SF, et al. Methods for studying intestinal sensitivity and compliance: in vitro studies of balloons and a barostat. Neurogastroenterol Motil. 1996;8:19-28.
112. Khan MI, Feinle C, Read NW. Investigating gastric and sensory response to distention: comparative studies using flaccid bags and latex balloons. 2nd United European Gastroenterology Meeting 1992;13:175.
113. Hu WHC, Martin CJ, Talley NJ. Intraesophageal acid perfusion sensitizes the esophagus to mechanical distension: a barostat study. Am J Gastroenterol. 2000;95:2189-2194.
114. Sun WM, Read NW, Prior A, et al. Sensory and motor responses to rectal distention vary according to rate and pattern of balloon inflation. Gastroenterology. 1990;99:1008-1015.
115. Munakata J, Naliboff B, Harraf F, et al. Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome. Gastroenterology. 1997;112:55-63.
116. Whitehead WE, Crowell MD, Shone D, et al. Sensitivity to rectal distension: validation of a measurement system (abstr). Gastroenterology. 1993;104:A600.
117. Lembo T, Niazi N, Mayer EA. Do mucosal mechanoreceptors contribute to rectal hyperalgesia in IBS patients? (abstr). Gastroenterology. 1993;104:A540.
118. Pehlivanov N, Liu J, Mittal R. Sustained esophageal contraction: a motor correlate of heartburn symptom. Gastroenterology. 1999;116:A1062.
119. Nguyen P, Castell DO. Stimulation of esophageal mechanoreceptors is dependent on rate and duration of distension. Am J Physiol. 1994;267: G115-G118.
120. Lasch H, Castell DO, Castell JA. Evidence of diminished visceral pain with aging: studies using graded intraesophageal balloon distension. Am J Physiol. 1997;272:G1-G3.
121. Fass R, Pulliam G, Johnson C, et al. Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastrooesophageal reflux. Age Ageing. 2000;29:125-130.
122. Nguyen P, Lee SD, Castell DO. Evidence of gender differences in esophageal pain threshold. Am J Gastroenterol. 1995;90:901-905.
123. Niemantsverdriet EC, Timmer R, Breumelhof R, et al. Regional differences in esophageal acid sensitivity studied with pH-controlled segmental acid perfusion. Gastroenterology. 1997;112:A237.
124. Winwood PJ, Mavrogiannis CC, Smith CL. Reduced sensitivity to intraoesophageal acid in patients with reflux-induced strictures. Scand J Gastroenterol. 1993;28:109-112.
125. Grade A, Pulliam G, Johnson C, et al. Reduced chemoreceptor sensitivity in patients with Barrett's esophagus may be related to age and not to the presence of Barrett's epithelium. Am J Gastroenterol. 1997;92:2040-2043.
126. Clouse RE, McCord GS, Lustman PJ, et al. Clinical correlates of abnormal sensitivity to intraesophageal balloon distension. Dig Dis Sci. 1991;36:1040-1045.
127. Mehta AJ, De Caestecker JS, Camm AJ, et al. Sensitization to painful distention and abnormal sensory perception in the esophagus. Gastroenterology. 1995;108:311-319.
128. Garrison DW, Chandler MJ, Foreman RD. Viscerosomatic convergence onto feline spinal neurons from esophagus, heart and somatic fields: effects of inflammation. Pain. 1992;49:373-382.
129. Peghini PL, Johnston BT, Leite LP, et al. Mucosal acid exposure sensitizes a subset of normal subjects to intra-oesophageal balloon distension. Eur J Gastroenterol Hepatol. 1996;8:979-983.
130. DeVault KR. Acid infusion does not affect intraesophageal balloon distention-induced sensory and pain thresholds. Am J Gastroenterol. 1997;92:947-949.
131. Sarkar S, Woolf CJ, Aziz Q, et al. Secondary hyperalgesia is induced by acid in the healthy human oesophagus (abstr). Gut. 1997;41:A26.
132. Cannon RO 3rd, Quyyumi AA, Mincemoyer R, et al. Imipramine in patients with chest pain despite normal coronary angiograms. N Engl J Med. 1994;330:1411-1417.
133. Peghini PL, Katz PO, Castell DO. Imipramine decreases oesophageal pain perception in human male volunteers. Gut. 1998;42:807-813.
134. Castell DO, Wood JD, Frieling T, et al. Cerebral electrical potentials evoked by balloon distention of the human esophagus. Gastroenterology. 1990;98:662-666.
135. DeVault KR. Nifedipine does not alter barostat determined esophageal smooth muscle tone. Gastroenterology. 1995;108:A591.
136. Smout AJ, DeVore MS, Dalton CB, et al. Effects of nifedipine on esophageal tone and perception of esophageal distension. Dig Dis Sci. 1992;37:598-602.
137. DeVault KR. Provocative tests for pain of esophageal origin. Applied sensory physiology. In: Castell DO, Richter JE, eds. The Esophagus. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 1999:135-143.
138. Hollerbach S, Kamath MV, Chen Y, et al. The magnitude of the central response to esophageal electrical stimulation is intensity dependent. Gastroenterology. 1997;112:1137-1146.
139. Smout AJ, DeVore MS, Castell DO. Cerebral potentials evoked by esophageal distension in human. Am J Physiol. 1990;259:G955-G959.
140. Frieling T, Enck P, Wienbeck M. Cerebral responses evoked by electrical stimulation of rectosigmoid in normal subjects. Dig Dis Sci. 1989;34:202-205.
141. DeVault KR, Beacham S, Castell DO, et al. Esophageal sensation in spinal cord-injured patients: balloon distension and cerebral evoked potential recording. Am J Physiol. 1996;271:G937-G941.
142. Franssen H, Weusten BL, Wieneke GH, et al. Source modeling of message evoked potentials. Electroencephalogr Clin Neurophysiol. 1996;100:85-95.
143. Aziz Q, Furlong PL, Barlow J, et al. Topographic mapping of cortical potentials evoked by distension of the human proximal and distal oesophagus. Electroencephalogr Clin Neurophysiol. 1995;96:219-228.
144. Aziz Q, Thompson DG. Brain-gut axis in health and disease. Gastroenterology. 1998;114:559-578.
145. Hartshorne MF. Positron emission tomography. In: Orrison WW, Lewine JD, Sanders JA, Hartshorne MF, eds. Functional Brain Imaging. St. Louis, MO: Mosby-Year Book; 1995:187-212.
146. Aine CJ. A conceptual overview and critique of functional neuroimaging techniques in humans: I. MRI/FMRI and PET. Crit Rev Neurobiol. 1995;9:229-309.
147. Sanders JA, Orrison WW. Functional magnetic resonance imaging. In: Orrison WW, Lewine JD, Sanders JA, Hartshorne MF, eds. Functional Brain Imaging. St. Louis, MO: Mosby-Year Book; 1995:239-326.