Interaction between metabolism and transport of toxicologically relevant substances in the gastrointestinal barrier;Interaktion zwischen metabolismus und transport von toxikologisch relevanten substanzen in der gastrointestinalen barriere

BioSpektrum

Volumn 10, Issue 2, 2004, Pages 157-159

  Lampen, Alfonso ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSTATIC AGENT; TOXIC SUBSTANCE;

DETOXIFICATION; ENZYME ACTIVATION; ENZYME METABOLISM; FOOD CONTAMINATION; GASTROINTESTINAL TRACT; HUMAN; METABOLISM; PERMEABILITY BARRIER; PROTEIN TRANSPORT; SHORT SURVEY;

EID: 4143058980     PISSN: 09470867     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (8)

1. Christians, U., Benet, L., Lampen, A. (2002): Clinically significant drug interactions associated with tacrolimus. Review; Clinical Pharmacokinetics 41 (11): 813-51.
2. Suzuki H., Sugiyama Y. (2000): Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur J Pharm Sci. 12(1): 3-12.
3. Lampen A., Ebert B., Stumkat L., Seidel A., Jacob J. (2003): Effects of PAH on the Expression of drug metabolizing enzymes and ABC-transporter in the human Caco-2 cell culture model. BBA (eingereicht).
4. Lampen A., Bader A., Bestmann T., Winkler M., Borlak J.T. (1998): Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. Xenobiotica 28, 429-441.
5. Boulenc, X., Bourrie, M., Fabre, I., Roque, C., Berger, Y., Fabre, G. (1992): Regulation of cytochrome CYP1A1 gene expression in a human intestinal cell line, Caco-2. Pharmacol. Exp. Ther. 263, 1471-1478.
6. Artursson, P., Karlsson, J. (1991): Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175, 880-885.
7. Buesen, R., Mock, M., Nau, H., Seidel, A., Jacob, J., Lampen, A. (2002): Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes. Tax. Appl. Pharm. 183:168.
8. Buesen, R., Mock, M., Nau, H., Seidel, A., Jacob, J., Lampen, A. (2003): Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolistes. Chem. Biol. Inter. 6; 142(3): 201-2.