An antimalarial neem leaf extract has both schizonticidal and gametocytocidal activities

American Journal of Therapeutics

Volumn 15, Issue 2, 2008, Pages 108-110

  Udeinya, J I ^a,e   Shu, E N ^b   Quakyi, I ^c   Ajayi, F O ^d  

^a ROCITUS Institute Research   (Nigeria)

^b UNIVERSITY OF NIGERIA   (Nigeria)

^c GEORGETOWN UNIVERSITY   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Antimalarial; Gametocytocidal; Malaria; Neem leaf extract; Schizonticidal

Indexed keywords

AZADIRACHTA INDICA EXTRACT;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; GAMETOCYTE; IN VITRO STUDY; NONHUMAN; PARASITEMIA; PLANT LEAF; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT; TROPHOZOITE;

ANIMALS; ANTIMALARIALS; AZADIRACHTA; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMETOGENESIS; PLANT EXTRACTS; PLANT LEAVES; PLASMODIUM FALCIPARUM; REPRODUCTION; SCHIZONTS;

EID: 41349119016     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/MJT.0b013e31804c6d1d     Document Type: Article

References (14)

1. Looareesuwan S, Chulay JD, Condfield CJ, et al. Malarone ™ (atorquone and proguanil hydrochloride): a review of its clinical development for reaction of malaria. Am J Trop Med Hyg. 1999;60:533-541.
2. Mutabingwa TK, Maxwell CA, Sia IG, et al. A trial of proguanil-dapsone in Plasmodium falciparum infections in Tanzania. Trans R Soc Trop Med Hyg. 2001;95:433-438.
3. World Health Organization. The use of antimalarial drugs. Report of a WHO Informal Consultation, 13-17 November 2000. WHO/CDS/RBM/2001.33. Geneva: World Health Organization, 2001.
4. World Health Organization. Country strategies and resource requirements, 2001. WHO/CDS/RBM/2001.34. Geneva: World Health Organization, 2001.
5. Brown HW, Neva FA, eds. Basic Clinical Parasitology, ed 4. New York: Appleton-Century-Crafts; 1983.
6. Ekanem OJ. Has Azadirachta indica (Dongo yaro) any antimalarial activity? Nigerian Med J. 1971;8:8-11.
7. Badam L, Deolankar RP, Kulkarni MM, et al. In vitro antimalarial activity of neem (A. indica A Juss) leaf and seed extracts. Indian J Malariol. 1987;24:111-117.
8. Koul P, Isman MB, Ketkar CM. Properties and uses of neem, Azadirachta indica. Can J Botany. 1987;68:1-11.
9. Jones IW, Denholm AA, Ley SV, et al. 1994. Sexual development of malaria parasites is inhibited by the neem extract azadirachtin, and its semi-synthetic analogues. FEMS Microbiol Lett. 1994;120:267-273.
10. Udeinya IJ. Antimalarial of activity of Nigerian neem leaves. Trans R Soc Trop Med Hyg. 1993;87:471.
11. Trager W, Jensen JB, Human malarial parasites in continuous culture. Science. 1976;193:673-675.
12. Lambros C, Vanderberg JP. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol. 1979;65:418-420.
13. Dahr R, Zhang K, Talwar GP, et al. Inhibition of the growth and development of asexual and sexual stages of drug-sensitive and resistant strains of the human malaria parasite Plasmodium falciparum by Neem (Azadirachta indica) fractions. J Ethnopharmacol. 1998;61:31-39.
14. Udeinya IJ, Mbah AU, Chijioke CP, et al. An antimalarial extract from neem leaves is antiretroviral. Trans R Soc Trop Med Hyg. 2004;98:435-437.