Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro

Journal of Medicinal Food

Volumn 11, Issue 1, 2008, Pages 14-20

  Ishikawa, Yasuko ^a,b   Tokura, Tomoko ^a   Nakano, Nobuhiro ^a   Hara, Mutsuko ^a   Niyonsaba, François ^a   Ushio, Hiroko ^a   Yamamoto, Yuji ^b   Tadokoro, Tadahiro ^b   Okumura, Ko ^a   Ogawa, Hideoki ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

Allergy; Bee pollen; Fc immunoglobulin E receptor; Immunoglobulin E; Mast cell

Indexed keywords

ANTIALLERGIC AGENT; FC RECEPTOR; IMMUNOGLOBULIN E; POLLEN EXTRACT; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; B LYMPHOCYTE; BEE EXTRACT; CELL ACTIVATION; CYTOKINE PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PATHOGENESIS; POLLEN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; BEES; BONE MARROW CELLS; CELL DEGRANULATION; CYTOKINES; IMMUNOGLOBULIN E; MAST CELLS; MICE; MICE, INBRED BALB C; PASSIVE CUTANEOUS ANAPHYLAXIS; PHOSPHORYLATION; POLLEN; PROTEIN-TYROSINE KINASES; RECEPTORS, IGE;

APIS MELLIFERA; APOIDEA; MUS;

EID: 41349109613     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2006.163     Document Type: Article

References (25)

1. Campos M, Markham KR, Mitchell KA, da Chunha AP: An approach to the characterization of bee pollens via their flavonoid/phenolic profiles. Phytochem Anal 1997;8:181-185.
2. Linskens HF, Jorde W: Pollen as food and medicine - a review. Economic Botany 1997;51:78-87.
3. Traidl-Hoffmann C, Kasche A, Menzel A, Jakob T, Thiel M, Ring J, Behrendt H: Impact of pollen on human health: more than allergen carriers? Int Arch Allergy Immunol 2003;131:1-13.
4. Middleton E Jr: Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol 1998;439:175-182.
5. Dudov IA, Starodub NF: Antioxidant system of rat erythrocytes under conditions of prolonged intake of honeybee flower pollen load. Ukr Biokhim Zh 1994;66:94-96.
6. Dudov IA, Morenets AA, Artiukh VP, Starodub NF: Immunomodulatory effect of honeybee flower pollen load. Ukr Biokhim Zh 1994;66:91-93.
7. Buck AC, Rees RW, Ebeling L: Treatment of chronic prostatitis and prostatodynia with pollen extract. Br J Urol 1989;64:496-499.
8. Shoskes DA: Phytotherapy in chronic prostatitis. Urology 2002;60:35-37.
9. Loschen G, Ebeling L: Inhibition of arachidonic acid cascade by extract of rye pollen. Arzneimittelforschung 1991;41:162-167.
10. Theoharides TC, Bielory L: Mast cells and mast cell mediators as targets of dietary supplements. Ann Allergy Asthma Immunol 2004;93(Suppl):S24- S34.
11. Stickl H, Kerscher G: Treatment of hay fever with new pollen capsules. Fortschr Med 1980;98:343-346.
12. Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol 2001;167:2250-2256.
13. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H: Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest 2002;109:1351-1359.
14. Razin E, Mencia-Huerta JM, Stevens RL, Lewis RA, Liu FT, Corey E, Austen KF: IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells. J Exp Med 1983;157:189-201.
15. Koda A, Miura T, Inagaki N, Sakamoto O, Arimura A, Nagai H, Mori H: A method for evaluating anti-allergic drugs by simultaneously induced passive cutaneous anaphylaxis and mediator cutaneous reactions. Int Arch Allergy Appl Immunol 1990;92:209-216.
16. Shiue L, Zoller MJ, Brugge JS: Syk is activated by phosphotyrosine- containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem 1995;270:10498-10502.
17. Tokura T, Nakano N, Ito T, Matsuda H, Nagasako-Akazome Y, Kanda T, Ikeda M, Okumura K, Ogawa H, Nishiyama C: Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and FcepsilonRI. Biosci Biotechnol Biochem 2005;69:1974-1977.
18. Kanda T, Akiyama H, Yanagida A, Tanabe M, Goda Y, Toyoda M, Teshima R, Saito Y: Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells. Biosci Biotechnol Biochem 1998;62:1284-1289.
19. Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC: Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol 2005;145:934-944.
20. Shichijo M, Yamamoto N, Tsujishita H, Kimata M, Nagai H, Kokubo T: Inhibition of syk activity and degranulation of human mast cells by flavonoids. Biol Pharm Bull 2003;26:1685-1690.
21. Bevzo VV, Grygor'eva NP: Effect of bee pollen extract on glutathione system activity in mice liver under X-ray irradiation. Ukr Biokhim Zh 1997;69:115-117.
22. Suzuki Y, Yoshimaru T, Inoue T, Niide O, Ra C: Role of oxidants in mast cell activation. Chem Immunol Allergy 2005;87:32-42.
23. Gushchin IS, Petyaev IM, Tsinkalovsky OR: Kinetics of oxygen metabolism indices in the course of histamine secretion from rat mast cells. Agents Actions 1990;30:85-88.
24. Foreman JC: Mast cells and the actions of flavonoids. J Allergy Clin Immunol 1984;73:769-774.
25. Kimata M, Inagaki N, Nagai H: Effects of luteolin and other flavonoids on IgE-mediated allergic reactions. Planta Med 2000;66:25-29.