메뉴 건너뛰기




Volumn 134, Issue 4, 2008, Pages 1104-1115

Perturbation of Hoxb5 Signaling in Vagal Neural Crests Down-Regulates Ret Leading to Intestinal Hypoganglionosis in Mice

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; HOX PROTEIN; PROTEIN ENB5; PROTEIN HOXB5; PROTEIN RET; UNCLASSIFIED DRUG;

EID: 41349099140     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.01.028     Document Type: Article
Times cited : (46)

References (35)
  • 1
    • 34249007508 scopus 로고    scopus 로고
    • Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies
    • Heanue T.A., and Pachnis V. Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. Nat Rev Neurosci 8 (2007) 466-479
    • (2007) Nat Rev Neurosci , vol.8 , pp. 466-479
    • Heanue, T.A.1    Pachnis, V.2
  • 2
    • 0041520957 scopus 로고    scopus 로고
    • Hirschsprung disease is linked to defects in neural crest stem cell function
    • Iwashita T., Kruger G.M., Pardal R., et al. Hirschsprung disease is linked to defects in neural crest stem cell function. Science 301 (2003) 972-976
    • (2003) Science , vol.301 , pp. 972-976
    • Iwashita, T.1    Kruger, G.M.2    Pardal, R.3
  • 3
    • 0036832278 scopus 로고    scopus 로고
    • Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    • Natarajan D., Marcos-Gutierrez C., Pachnis V., et al. Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. Development 129 (2002) 5151-5160
    • (2002) Development , vol.129 , pp. 5151-5160
    • Natarajan, D.1    Marcos-Gutierrez, C.2    Pachnis, V.3
  • 4
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A., D'Agati V., Larsson-Blomberg L., et al. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367 (1994) 380-383
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D'Agati, V.2    Larsson-Blomberg, L.3
  • 5
    • 0032132829 scopus 로고    scopus 로고
    • Role of the RET signal transduction pathway in development of the mammalian enteric nervous system
    • Pachnis V., Durbec P., Taraviras S., et al. Role of the RET signal transduction pathway in development of the mammalian enteric nervous system. Am J Physiol 275 (1998) G183-G186
    • (1998) Am J Physiol , vol.275
    • Pachnis, V.1    Durbec, P.2    Taraviras, S.3
  • 6
    • 0027219581 scopus 로고
    • A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10
    • Angrist M., Kauffman E., Slaugenhaupt S.A., et al. A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10. Nat Genet 4 (1993) 351-356
    • (1993) Nat Genet , vol.4 , pp. 351-356
    • Angrist, M.1    Kauffman, E.2    Slaugenhaupt, S.A.3
  • 7
    • 0027972513 scopus 로고
    • Mutations of the RET proto-oncogene in Hirschsprung's disease
    • Edery P., Lyonnet S., Mulligan L.M., et al. Mutations of the RET proto-oncogene in Hirschsprung's disease. Nature 367 (1994) 378-380
    • (1994) Nature , vol.367 , pp. 378-380
    • Edery, P.1    Lyonnet, S.2    Mulligan, L.M.3
  • 8
    • 0028120882 scopus 로고
    • Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease
    • Romeo G., Ronchetto P., Luo Y., et al. Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature 367 (1994) 377-378
    • (1994) Nature , vol.367 , pp. 377-378
    • Romeo, G.1    Ronchetto, P.2    Luo, Y.3
  • 9
    • 0034602646 scopus 로고    scopus 로고
    • A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus
    • Bolk S., Pelet A., Hofstra R.M., et al. A human model for multigenic inheritance: phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus. Proc Natl Acad Sci U S A 97 (2000) 268-273
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 268-273
    • Bolk, S.1    Pelet, A.2    Hofstra, R.M.3
  • 10
    • 0036788576 scopus 로고    scopus 로고
    • Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
    • Carrasquillo M.M., McCallion A.S., Puffenberger E.G., et al. Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. Nat Genet 32 (2002) 237-244
    • (2002) Nat Genet , vol.32 , pp. 237-244
    • Carrasquillo, M.M.1    McCallion, A.S.2    Puffenberger, E.G.3
  • 11
    • 18544365991 scopus 로고    scopus 로고
    • Segregation at three loci explains familial and population risk in Hirschsprung disease
    • Gabriel S.B., Salomon R., Pelet A., et al. Segregation at three loci explains familial and population risk in Hirschsprung disease. Nat Genet 31 (2002) 89-93
    • (2002) Nat Genet , vol.31 , pp. 89-93
    • Gabriel, S.B.1    Salomon, R.2    Pelet, A.3
  • 12
    • 0027953771 scopus 로고
    • Hox genes in vertebrate development
    • Krumlauf R. Hox genes in vertebrate development. Cell 78 (1994) 191-201
    • (1994) Cell , vol.78 , pp. 191-201
    • Krumlauf, R.1
  • 13
    • 0041857928 scopus 로고    scopus 로고
    • HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts
    • Fu M., Lui V.C.H., Sham M.H., et al. HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts. Dev Dyn 228 (2003) 1-10
    • (2003) Dev Dyn , vol.228 , pp. 1-10
    • Fu, M.1    Lui, V.C.H.2    Sham, M.H.3
  • 14
    • 0032714049 scopus 로고    scopus 로고
    • Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code
    • Pitera J.E., Smith V.V., Thorogood P., et al. Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code. Gastroenterology 117 (1999) 1339-1351
    • (1999) Gastroenterology , vol.117 , pp. 1339-1351
    • Pitera, J.E.1    Smith, V.V.2    Thorogood, P.3
  • 15
    • 0026684136 scopus 로고
    • Expression and modification of Hox 2.1 protein in mouse embryos
    • Wall N.A., Jones C.M., Hogan B.L., et al. Expression and modification of Hox 2.1 protein in mouse embryos. Mech Dev 37 (1992) 111-120
    • (1992) Mech Dev , vol.37 , pp. 111-120
    • Wall, N.A.1    Jones, C.M.2    Hogan, B.L.3
  • 16
    • 0028859990 scopus 로고
    • Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation
    • Rancourt D.E., Tsuzuki T., and Capecchi M.R. Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev 9 (1995) 108-122
    • (1995) Genes Dev , vol.9 , pp. 108-122
    • Rancourt, D.E.1    Tsuzuki, T.2    Capecchi, M.R.3
  • 17
    • 0025759962 scopus 로고
    • Active repression of transcription by the engrailed homeodomain protein
    • Jaynes J.B., and O'Farrell P.H. Active repression of transcription by the engrailed homeodomain protein. EMBO J 10 (1991) 1427-1433
    • (1991) EMBO J , vol.10 , pp. 1427-1433
    • Jaynes, J.B.1    O'Farrell, P.H.2
  • 18
    • 0029021867 scopus 로고
    • Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo
    • John A., Smith S.T., and Jaynes J.B. Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo. Development 121 (1995) 1801-1813
    • (1995) Development , vol.121 , pp. 1801-1813
    • John, A.1    Smith, S.T.2    Jaynes, J.B.3
  • 19
    • 0034079665 scopus 로고    scopus 로고
    • A β-catenin/engrailed chimera selectively suppresses Wnt signaling
    • Montross W.T., Ji H., and McCrea P.D. A β-catenin/engrailed chimera selectively suppresses Wnt signaling. J Cell Sci 113 (2000) 1759-1770
    • (2000) J Cell Sci , vol.113 , pp. 1759-1770
    • Montross, W.T.1    Ji, H.2    McCrea, P.D.3
  • 20
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21 (1999) 70-71
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 21
    • 0033561410 scopus 로고    scopus 로고
    • Z/AP, a double reporter for cre-mediated recombination
    • Lobe C.G., Koop K.E., Kreppner W., et al. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208 (1999) 281-292
    • (1999) Dev Biol , vol.208 , pp. 281-292
    • Lobe, C.G.1    Koop, K.E.2    Kreppner, W.3
  • 22
    • 19544378341 scopus 로고    scopus 로고
    • Hoxb3 vagal neural crest-specific enhancer element for controlling enteric nervous system development
    • Chan K.K., Chen Y.S., Yau T.O., et al. Hoxb3 vagal neural crest-specific enhancer element for controlling enteric nervous system development. Dev Dyn 233 (2005) 473-483
    • (2005) Dev Dyn , vol.233 , pp. 473-483
    • Chan, K.K.1    Chen, Y.S.2    Yau, T.O.3
  • 23
    • 19944430369 scopus 로고    scopus 로고
    • TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease
    • Garcia-Barcelo M., Ganster R.W., Lui V.C., et al. TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease. Hum Mol Genet 14 (2005) 191-204
    • (2005) Hum Mol Genet , vol.14 , pp. 191-204
    • Garcia-Barcelo, M.1    Ganster, R.W.2    Lui, V.C.3
  • 24
    • 0027265820 scopus 로고
    • Colonization of the bowel by neural crest-derived cells re-migrating from foregut backtransplanted to vagal or sacral regions of host embryos
    • Rothman T.P., Le Douarin N.M., Fontaine-Perus J.C., et al. Colonization of the bowel by neural crest-derived cells re-migrating from foregut backtransplanted to vagal or sacral regions of host embryos. Dev Dyn 196 (1993) 217-233
    • (1993) Dev Dyn , vol.196 , pp. 217-233
    • Rothman, T.P.1    Le Douarin, N.M.2    Fontaine-Perus, J.C.3
  • 25
    • 0347194147 scopus 로고    scopus 로고
    • Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET
    • Barlow A., de Graaff E., and Pachnis V. Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Neuron 40 (2003) 905-916
    • (2003) Neuron , vol.40 , pp. 905-916
    • Barlow, A.1    de Graaff, E.2    Pachnis, V.3
  • 26
    • 0034163569 scopus 로고    scopus 로고
    • Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia
    • Burns A.J., Champeval D., and Le Douarin N.M. Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia. Dev Biol 219 (2000) 30-43
    • (2000) Dev Biol , vol.219 , pp. 30-43
    • Burns, A.J.1    Champeval, D.2    Le Douarin, N.M.3
  • 27
    • 33846187723 scopus 로고    scopus 로고
    • Effect of Gdnf haploinsufficiency on rate of migration and number of enteric neural crest-derived cells
    • Flynn B., Bergner A.J., Turner K.N., et al. Effect of Gdnf haploinsufficiency on rate of migration and number of enteric neural crest-derived cells. Dev Dyn 236 (2007) 134-141
    • (2007) Dev Dyn , vol.236 , pp. 134-141
    • Flynn, B.1    Bergner, A.J.2    Turner, K.N.3
  • 28
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: signalling, biological functions and therapeutic value
    • Airaksinen M.S., and Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3 (2002) 383-394
    • (2002) Nat Rev Neurosci , vol.3 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 29
    • 0035883740 scopus 로고    scopus 로고
    • Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
    • de Graaff E., Srinivas S., Kilkenny C., et al. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev 15 (2001) 2433-2444
    • (2001) Genes Dev , vol.15 , pp. 2433-2444
    • de Graaff, E.1    Srinivas, S.2    Kilkenny, C.3
  • 30
    • 18044362169 scopus 로고    scopus 로고
    • Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival
    • Srinivasan S., Anitha M., Mwangi S., et al. Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival. Mol Cell Neurosci 29 (2005) 107-119
    • (2005) Mol Cell Neurosci , vol.29 , pp. 107-119
    • Srinivasan, S.1    Anitha, M.2    Mwangi, S.3
  • 31
    • 9444225531 scopus 로고    scopus 로고
    • Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis
    • Jain S., Naughton C.K., Yang M., et al. Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development 131 (2004) 5503-5513
    • (2004) Development , vol.131 , pp. 5503-5513
    • Jain, S.1    Naughton, C.K.2    Yang, M.3
  • 32
    • 0033609337 scopus 로고    scopus 로고
    • The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    • Pattyn A., Morin X., Cremer H., et al. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399 (1999) 366-370
    • (1999) Nature , vol.399 , pp. 366-370
    • Pattyn, A.1    Morin, X.2    Cremer, H.3
  • 33
    • 33646489010 scopus 로고    scopus 로고
    • Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes
    • Heanue T.A., and Pachnis V. Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A 103 (2006) 6919-6924
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6919-6924
    • Heanue, T.A.1    Pachnis, V.2
  • 34
    • 0029865897 scopus 로고    scopus 로고
    • Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA
    • Shen W.F., Chang C.P., Rozenfeld S., et al. Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nucleic Acids Res 24 (1996) 898-906
    • (1996) Nucleic Acids Res , vol.24 , pp. 898-906
    • Shen, W.F.1    Chang, C.P.2    Rozenfeld, S.3
  • 35
    • 0032536818 scopus 로고    scopus 로고
    • Selectivity, sharing and competitive interactions in the regulation of Hoxb genes
    • Sharpe J., Nonchev S., Gould A., et al. Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. EMBO J 17 (1998) 1788-1798
    • (1998) EMBO J , vol.17 , pp. 1788-1798
    • Sharpe, J.1    Nonchev, S.2    Gould, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.