A practical synthesis of the kappa opioid receptor selective agonist (+)-5R,7S,8S-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxospiro[4,5]dec-8-yl] benzeneacetamide (U69,593)

Synthesis

Volumn , Issue 6, 2008, Pages 943-947

  McElroy, Timothy ^a   Thomas, James B ^a   Brine, George A ^a   Navarro, Hernán A ^a   Deschamps, Jeffrey ^b   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Kappa opioid agonist; Receptors; Synthesis; U69,593; X ray crystal structure

Indexed keywords

KAPPA OPIOID AGONIST; RECEPTORS; X-RAY CRYSTAL STRUCTURE;

ASSAYS; CRYSTAL STRUCTURE; EPOXIDATION; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL); X RAY ANALYSIS;

AMIDES;

EPOXIDE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXOSPIRO[4,5]DEC 8 YL]BENZENEACETAMIDE; SULFATE; U 69 593; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; BIOLOGICAL ACTIVITY; DRUG SYNTHESIS; QUANTITATIVE ANALYSIS; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 41349092513     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1032185     Document Type: Article

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