Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics

Pharmacology

Volumn 81, Issue 3, 2008, Pages 195-

  Ahrens, Jörg ^a   Leuwer, Martin ^b   Haeseler, Gertrud ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Glycine receptor; Propofol; Volatile anaesthetics

Indexed keywords

ALCOHOL; GLYCINE RECEPTOR; INHALATION ANESTHETIC AGENT; PROPOFOL; STRYCHNINE;

ANALGESIC ACTIVITY; DRUG RECEPTOR BINDING; HYPNOSIS; NOCICEPTION; NOTE; PRIORITY JOURNAL; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION;

ANESTHETICS, INTRAVENOUS; DRUG DELIVERY SYSTEMS; HUMANS; PAIN; PROPOFOL; RECEPTORS, GLYCINE; STRYCHNINE; SYNAPTIC TRANSMISSION;

EID: 41349090336     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000112943     Document Type: Note

References (7)

1. Chen Y, Dai TJ, Zeng YM: Strychnine-sensitive glycine receptors mediate the analgesic but not hypnotic effects of emulsified volatile anesthetics. Pharmacology 2007;80:151-157.
2. A and glycine receptors. Nature 1997;389:385-389.
3. Belelli D, Lambert JJ, Peters JA, et al: The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proc Natl Acad Sci USA 1997;94:11031-11036.
4. Ahrens J, Haeseler G, Leuwer M, et al: 2,6 di-tert-butylphenol, a non-anesthetic propofol analog, modulates alpha1beta glycine receptor function in a manner distinct from propofol. Anesth Analg 2004;99:91-96.
5. Betz H, Laube B: Glycine receptors: recent insights into their structural organization and functional diversity. J Neurochem 2006;97:1600-1610.
6. Bolay H, Moskowitz MA: Mechanisms of pain modulation in chronic syndromes. Neurology 2002;59:S2-S7.
7. Laube B, Maksay G, Schemm R, Betz H: Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol Sci 2002;23:519-527.