An efficient one-pot synthesis of 3-substituted-5-amino-1,2,4-thiadiazoles from isothiocyanates and amidines

Tetrahedron Letters

Volumn 49, Issue 18, 2008, Pages 2869-2871

  Wu, Yong Jin ^a   Zhang, Yunhui ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; AMIDINE; ISOTHIOCYANIC ACID DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ONE POT SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

EID: 41349085760     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.03.030     Document Type: Article

References (8)

1. Yamanaka, T.; Ohki, H.; Ohgaki, M.; Okuda, S.; Toda, A.; Kawabata, K.; Inoue, S.; Misumi, K.; Itoh, K.; Satoh, K. U.S. Pat. Appl. Publ. US2005004094A1.
2. Boschelli, D. H.; Connor, D.T. U.S. Pat. Appl. Publ. US005114958A.
3. Kharimian, K.; Tam, T. F.; Leung-Toung, R. C.; Li, W. PCT Int. Appl. WO9951584A1.
4. Johnstone, C.; Mckerrecher, D.; Pike, K. G.; Waring, M.J. PCT Int. Appl. WO2005121110A1.
5. Franz J.E., and Dhingra O.P. In: Potts T.P. (Ed). Comprehensive Heterocyclic Chemistry. 1,2,4-Thiadiazoles Vol. 6, Chapter 4.25 (1984), Pergamon, New York 463-511
6. Lin L., Lang S.A., and Petty S.R. J. Org. Chem. 45 (1980) 3750
7. Kihara Y., Kabashima S., Uno K., Okawara T., Yamasaki T., and Furukawa M. Synthesis (1990) 1020
8. 32 S (M+H): 333.9831; found: 333.9825.