Ciprofloxacin in primary prophylaxis of spontaneous bacterial peritonitis: A randomized, placebo-controlled study

Journal of Hepatology

Volumn 48, Issue 5, 2008, Pages 774-779

  Terg, Rubén ^a   Fassio, Eduardo ^b   Guevara, Mónica ^c   Cartier, Mariano ^a   Longo, Cristina ^b   Lucero, Romina ^a   Landeira, Cristina ^b   Romero, Gustavo ^a   Dominguez, Nora ^b   Muñoz, Alberto ^a   Levi, Diana ^a   Miguez, Carlos ^a   Abecasis, Raquel ^a  

^a HOSPITAL DE GASTROENTEROLOGÍA DR CARLOS BONORINO UDAONDO   (Argentina)

^b HOSPITAL NACIONAL PROFESOR ALEJANDRO POSADAS   (Argentina)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Ciprofloxacin; Primary prophylaxis; Spontaneous bacterial peritonitis

Indexed keywords

ALBUMIN; CEFTRIAXONE; CIPROFLOXACIN; CIRIAX; COTRIMOXAZOLE; PLACEBO; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASCITES FLUID; BACTERIAL PERITONITIS; CAUSE OF DEATH; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FOLLOW UP; HEPATIC ENCEPHALOPATHY; HUMAN; INFECTION PREVENTION; KIDNEY FAILURE; LABORATORY TEST; LIVER CIRRHOSIS; LONG TERM CARE; MAJOR CLINICAL STUDY; NAUSEA; OPPORTUNISTIC INFECTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SPONTANEOUS BACTERIAL PERITONITIS; SURVIVAL RATE; TREATMENT DURATION; UPPER GASTROINTESTINAL BLEEDING;

ADULT; AGED; ANTI-INFECTIVE AGENTS; BACTERIAL INFECTIONS; CIPROFLOXACIN; HUMANS; MIDDLE AGED; PERITONITIS;

EID: 41249102819     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.01.024     Document Type: Article

References (28)

1. García Tsao G. Spontaneous bacterial peritonitis. Gastroenterol Clin North Am 21 (1992) 257-275
2. Caly W., and Strauss E. A prospective study of bacterial infections in patients with cirrhosis. J Hepatol 18 (1993) 353-358
3. Pinzello G., Simonetti R., Craxi A., Di Piazza S., Spano C., and Pagliaro L. Spontaneous bacterial perotinitis: a prospective investigation in predominantly nonalcoholic cirrhotic patients. Hepatology 3 (1983) 545-549
4. Levi D., Terg R., Podesta A., Abecasis R., Deglee G., and Raffaelli C. Infecciones bacterianas en el paciente cirrótico. Gastroenterologia y Hepatología 12 (1989) 384-388
5. Sort P., Navasa M., Arroyo V., Aldeguer X., Planas R., Ruiz del Arbol L., et al. Effects of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 341 (1999) 403-409
6. Ginés P., Rimola A., Planas R., Vargas V., Marco F., Almela M., et al. Norfloxacin prevents spontaneous bacterial peritonitis recurrence in cirrhosis: results of a double-blind, placebo-controlled trial. Hepatology 12 (1990) 716-724
7. Tito L.I., Rímola A., Ginés P., Llach J., Arroyo V., and Rodés J. Recurrence of spontaneous bacterial peritonitis in cirrhosis: frequency and predictive factors. Hepatology 8 (1988) 27-31
8. Silvain C., Besson I., Ingrand P., Mannant P.R., Fort E., and Beuchant M. Prognosis and long-term recurrence of spontaneous bacterial peritonitis in cirrhosis. J Hepatol 19 (1993) 188-189
9. Terg R., Levi D., Lopez P., Rafaelli C., Rojter S., Abecasis R., et al. Analysis of clinical course and prognosis of culture positive spontaneous bacterial peritonitis and neutrocytic ascites. Evidence of the same disease. Dig Dis Sci 37 (1992) 1499-1504
10. Bernard B., Grangé G.J., Khac E., Amio X., Opolon P., and Poynard T. Antibiotics prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 29 (1999) 1655-1661
11. Hou M., Lin H., Liu T., Kuo B., Lee F., Chang F., et al. Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial. Hepatology 39 (2004) 746-753
12. Llach J., Rimola A., Navasa M., Gines P., Salmeron J.M., Gines A., et al. Incidence and predictive factors of first episode of spontaneous bacterial peritonitis in cirrhosis with ascites: relevance of ascitic fluid protein concentration. Hepatology 16 (1992) 724-727
13. Runyon B. Low-protein-concentration ascitic fluid is predisposed to spontaneous bacterial peritonitis. Gastroenterology 91 (1986) 1343-1346
14. Novella M., Solá R., Soriano G., Andreu M., Gana J., Ortiz J., et al. Continuous vs. inpatient prophylaxis of the first episode of spontaneous bacterial peritonitis in cirrhotic patients with norfloxacin. Hepatology 25 (1997) 532-536
15. Grange J.D., Roulot D., Pelletier G., Pariente E.A., Denis J., Ink O., et al. Primary prophylaxis of bacterial infections with norfloxacin in cirrhotic patients with ascites: results of a double-blind, placebo-controlled trial. J Hepatol 29 (1998) 430-436
16. Rolachon A., Cordier L., Bacq Y., Nousbaum J.B., Franza A., Paris J.C., et al. Ciprofloxacin and long-term prevention of spontaneous bacterial peritonitis: results of a prospective controlled trial. Hepatology 22 (1995) 1171-1174
17. Singh N., Gayowski T., Yu V.L., and Wagener M.M. Trimethoprim-sulfamethoxazole for the prevention of spontaneous bacterial peritonitis in cirrhosis: a randomised trial. Ann Intern Med 122 (1995) 595-598
18. Guarner C., Solá R., Soriano G., Andreu M., Novella M., Vila M., et al. Risk of a first community-acquired spontaneous bacterial peritonitis in cirrhotic with low ascitic fluid protein levels. Gastroenterology 117 (1999) 414-419
19. Fernandez J., Navasa M., Planas R., Montoliu S., Montfort D., Soriano G., et al. Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improve survival in cirrhosis. Gastroenterology 133 (2007) 818-824
20. Singh N., Wagener M., and Gayowski T. Changing epidemiology and predictors of mortality in patients with spontaneous bacterial peritonitis at a liver transplant unit. Clin Microbiol Infect 9 (2003) 531-537
21. Fernandez J., Navasa M., Gomez J., Colmenero J., Vila J., Arroyo V., et al. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology 35 (2002) 140-148
22. Dupeyron C., Mangeney N., Sedrati L., Campillo B., Fouet P., and Leluan G. Rapid emergence of quinolone resistance in cirrhotic patients treated with norfloxacin to prevent spontaneous bacterial peritonitis. Antimicrob Agents Chemother 38 (1994) 340-344
23. Campillo B., Dupeyron C., Richardet J., Mangeney N., and Leluan G. Epidemiology of severe hospital acquired infections in patients with liver cirrhosis: effects of long term administration of norfloxacin. Clin Infect Dis 26 (1998) 1066-1070
24. Cirera I., Bauer T., Navasa M., Vila J., Grande L., Taura P., et al. Bacterial translocation of enteric organism in patients with cirrhosis. J Hepatol 34 (2001) 32-37
25. Runyon B., Borzio M., Young S., Squier S., Guarner C., and Runyon M. Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation and survival in an animal model of cirrhosis. Hepatology 21 (1995) 1719-1724
26. Llovet J., Bartolí R., Planas R., Viñado B., Arnal J., Ojanguren I., et al. Selective intestinal decontamination with norfloxacin reduces bacterial translocation in ascitic cirrhotic rats exposed to haemorrhagic shock. Hepatology 23 (1996) 781-787
27. Chin-Dusting J., Rasaratnam B., Jennings G., and Dudley F. Effect of fluoroquinolone on the enhanced nitric oxide induced peripheral vasodilation seen in cirrhosis. Ann Int Med 127 (1997) 985-988
28. Rasaratnam B., Kaye D., Jenning G., Dudley F., and Chin-Dustin J. The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. Ann Intern Med 139 (2003) 186-193