Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3224-3232

  Farina, Carlo ^a   Gagliardi, Stefania ^b   Ghelardini, Carla ^c   Martinelli, Marisa ^b   Norcini, Monica ^c   Parini, Carlo ^b   Petrillo, Paola ^b   Ronzoni, Silvano ^a  

^a Brane Discovery   (Italy)

^b NiKem Research   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

CCI; Neuropathic pain; Nootropic drugs; Streptozocin

Indexed keywords

ANALGESIC AGENT; DIMIRACETAM; ETIRACETAM; GABAPENTIN; IMIDAZOLE DERIVATIVE; NEFIRACETAM; PYRROLE DERIVATIVE; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TOLERABILITY; IN VIVO STUDY; MALE; NERVE INJURY; NEUROPATHIC PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN THRESHOLD; PRESSURE; RAT; ROTAROD TEST; SCIATIC NEUROPATHY;

ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; IMIDAZOLES; NEURALGIA; PAIN THRESHOLD; PYRROLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 41249097096     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.015     Document Type: Article

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