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Catalyst 13a did not catalyze the addition of HCN itself to imine substrates.
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Catalyst 13a did not catalyze the addition of HCN itself to imine substrates.
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0001366183
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A referee has pointed out that in the presence of stoichiometric amounts of isopropyl alcohol, an analogous catalysis mode involving the activation of HCN by the quinuclidine ring nitrogen could also be considered. For a discussion of the influence of protic additives see
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A referee has pointed out that in the presence of stoichiometric amounts of isopropyl alcohol, an analogous catalysis mode involving the activation of HCN by the quinuclidine ring nitrogen could also be considered. For a discussion of the influence of protic additives see: M. Takamura, Y. Hamashima, H. Usuda, M. Kanai, M. Shibasaki, Angew. Chem. 2000, 112, 1716;
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3 catalyst: G. K. S. Prakash, T. Matthew, C. Panja, S. Alconcel, H. Vaghoo, C. Do, G. A. Olah, Proc. Natl. Acad. Sci. USA 2007, 104, 3703.
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