Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances

Biochemical Pharmacology

Volumn 75, Issue 8, 2008, Pages 1616-1622

  Terazono, Hideyuki ^a   Hamdan, Ahmed ^a   Matsunaga, Naoya ^a   Hayasaka, Naoto ^b   Kaji, Hiroaki ^c   Egawa, Takashi ^c   Makino, Kazutaka ^c   Shigeyoshi, Yasufumi ^b   Koyanagi, Satoru ^a   Ohdo, Shigehiro ^a  

^a Pharmaceutics   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHUJITSU UNIVERSITY   (Japan)

Author keywords

5 Fluorouracil; Chemotherapy; Circadian rhythm; Clock genes; Suprachiasmatic nuclei

Indexed keywords

FLUOROURACIL; MESSENGER RNA; PER1 PROTEIN; PER2 PROTEIN; URACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CELL STRAIN 3T3; CELL VIABILITY; CIRCADIAN RHYTHM; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPRACHIASMATIC NUCLEUS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL CYCLE PROTEINS; CIRCADIAN RHYTHM; FLUOROURACIL; GENE EXPRESSION REGULATION; LIVER; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; NIH 3T3 CELLS; NUCLEAR PROTEINS; RNA, MESSENGER; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION FACTORS;

EID: 41249090029     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.01.011     Document Type: Article

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