Relationship between HIV-RNA load in blood and semen in antiretroviral naïve and experience men and effect of asymptomatic sexually transmissible infections

Current HIV Research

Volumn 6, Issue 2, 2008, Pages 138-142

  Chan, Derek J ^a   McNally, Leon ^b   Batterham, Marjika ^c   Smith, Don E ^a  

^a PRINCE OF WALES HOSPITAL   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Human immunodeficiency virus; Semen; Sexual transmission; Sexually transmissible infection; Viral load

Indexed keywords

ANTIRETROVIRUS AGENT; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VIRUS RNA;

ADULT; BIOCHEMISTRY; CD4 LYMPHOCYTE COUNT; CHLAMYDIASIS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFICACY; GONORRHEA; HEMATOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; REVIEW; RISK REDUCTION; SAMPLING; SCREENING TEST; SEMEN ANALYSIS; SEMINAL PLASMA; SEXUALLY TRANSMITTED DISEASE; SYPHILIS; TREATMENT RESPONSE; VIRUS LOAD; ARTICLE; BLOOD; CROSS-SECTIONAL STUDY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; MIDDLE AGED; PATHOPHYSIOLOGY; PREVALENCE; SPERM; VIROLOGY;

ADULT; ANTI-HIV AGENTS; BLOOD; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; CROSS-SECTIONAL STUDIES; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; PREVALENCE; RNA, VIRAL; SEMEN; SEXUALLY TRANSMITTED DISEASES; VIRAL LOAD;

EID: 41249086368     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016208783885074     Document Type: Review

References (32)

1. Wasserheit JN. Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Transm Dis 1992;19:61-77.
2. Wasserheit JN. HIV infection and other STDs: so close and yet so far. Sex Transm Dis 1999;26:549-550.
3. Chakraborty H, Sen PK, Helms RW, et al. Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. AIDS 2001; 15: 621-627.
4. Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect 1999; 75: 3-17.
5. Kuiken CL, van Griensven GJ, de Vroome EM, Coutinho RA. Risk factors and changes in sexual behavior in male homosexuals who seroconverted for human immunodeficiency virus antibodies. Am J Epidemiol 1990; 132: 523-530.
6. Darrow WW, Echenberg DF, Jaffe HW, et al. Risk factors for human immunodeficiency virus (HIV) infections in homosexual men. Am J Public Health 1987; 77: 479-483.
7. Otten MW, Jr., Zaidi AA, Peterman TA, Rolfs RT, Witte JJ. High rate of HIV seroconversion among patients attending urban sexually transmitted disease clinics. AIDS 1994; 8: 549-553.
8. Buchacz K, Patel P, Taylor M, et al. Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS 2004; 18: 2075-2079.
9. Sturm-Ramirez K, Gaye-Diallo A, Eisen G, Mboup S, Kanki PJ. High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus. J Infect Dis 2000; 182: 467-473.
10. Wawer MJ, Sewankambo NK, Serwadda D, et al. Control of sexually transmitted diseases for AIDS prevention in Uganda: a randomised community trial. Rakai Project Study Group. Lancet 1999; 353: 525-535.
11. Kashuba AD, Dyer JR, Kramer LM, Raasch RH, Eron JJ, Cohen MS. Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1. Antimicrob Agents Chemother 1999; 43: 1817-1826.
12. Fiscus SA, Brambilla D, Coombs RW, et al. Multicenter evaluation of methods to quantitate human immunodeficiency virus type, 1 RNA in seminal plasma. J Clin Microbiol 2000; 38: 2348-2353.
13. Boom R, Sol CJ, Salimans MM, Jansen CL, Wertheim-van Dillen PM, van der Noordaa J. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990; 28: 495-503.
14. Eron JJ, Jr., Smeaton LM, Fiscus SA, et al. The effects of protease inhibitor therapy on human immunodeficiency virus type 1 levels in semen (AIDS clinical trials group protocol 850). J Infect Dis 2000; 181: 1622-1628.
15. Chan DJ. Fatal attraction: sex, sexually transmitted infections and HIV-1. Int J STD AIDS 2006; 17: 643-651.
16. Fiscus SA. Quantitation of HIV-1 viral RNA in blood plasma and genital secretions. Methods Mol Biol 2005; 304: 201-213.
17. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49: 1373-1379.
18. Schacker T. The role of HSV in the transmission and progression of HIV. Herpes 2001; 8: 46-49.
19. Chen CY, Ballard RC, Beck-Sague CM, et al. Human immunodeficiency virus infection and genital ulcer disease in South Africa: the herpetic connection. Sex Transm Dis 2000; 27: 21-29.
20. Schacker T, Ryncarz AJ, Goddard J, Diem K, Shaughnessy M, Corey L. Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. JAMA 1998; 280: 61-66.
21. Gadkari DA, Quinn TC, Gangakhedkar RR, et al. HIV-1 DNA shedding in genital ulcers and its associated risk factors in Pune, India. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 18: 277-281.
22. Gray RH, Wawer MJ, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet 2001; 357: 1149-1153.
23. Gupta P, Mellors J, Kingsley L, et al. High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors. J Virol 1997; 71: 6271-6275.
24. Hamed KA, Winters MA, Holodniy M, Katzenstein DA, Merigan TC. Detection of human immunodeficiency virus type 1 in semen: effects of disease stage and nucleoside therapy. J Infect Dis 1993; 167: 798-8102.
25. Mermin JH, Holodniy M, Katzenstein DA, Merigan TC. Detection of human immunodeficiency virus DNA and RNA in semen by the polymerase chain reaction. J Infect Dis 1991; 164: 769-772.
26. Zagury D, Bernard J, Leibowitch J, et al. HHV IU in cells cultured from semen of two patients with AIDS. Science 1984; 226: 449-451.
27. Vernazza PL, Eron JJ, Fiscus SA. Sensitive method for the detection of infectious HIV in semen of seropositive individuals. J Virol Methods 1996; 56: 33-40.
28. Mostad SB, Jackson S, Overbaugh J, et al. Cervical and vaginal shedding of human immunodeficiency virus type 1-infected cells throughout the menstrual cycle. J Infect Dis 1998; 178: 983-991.
29. Coombs RW, Speck CE, Hughes JP, et al. Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood. J Infect Dis 1998; 177: 320-330.
30. Vernazza PL, Gilliam BL, Dyer J, et al. Quantification of HIV in semen: correlation with antiviral treatment and immune status. AIDS 1997; 11: 987-993.
31. Dyer JR, Gilliam BL, Eron JJ, Jr., Grosso L, Cohen MS, Fiscus SA. Quantitation of human immunodeficiency virus type 1 RNA in cell free seminal plasma: comparison of NASBA with Amplicor reverse transcription-PCR amplification and correlation with quantitative culture. J Virol Methods 1996; 60: 161-170.
32. Quinn TC, Wawer MJ, Sewankambo, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000; 342: 921-929.