Interhemispheric transfer deficit in alexithymia: A transcranial magnetic stimulation study

Psychotherapy and Psychosomatics

Volumn 77, Issue 3, 2008, Pages 175-181

  Romei, Vincenzo ^a,d   De Gennaro, Luigi ^a   Fratello, Fabiana ^a   Curcio, Giuseppe ^a   Ferrara, Michele ^b   Pascual Leone, Alvaro ^c   Bertini, Mario ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Alexithymia; Corpus callosum; Interhemispheric transfer; Paired pulse; Transcallosal inhibition; Transcranial magnetic stimulation

Indexed keywords

ADULT; ALEXITHYMIA; ARTICLE; BRAIN DYSFUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; EVOKED MUSCLE RESPONSE; FEMALE; HAND MUSCLE; HUMAN; HYPOTHESIS; INTERHEMISPHERIC TRANSFER; INTERHEMISPHERIC TRANSFER DEFICIT; MALE; MOTOR CORTEX; NEUROPATHOLOGY; PRIORITY JOURNAL; RATING SCALE; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; AFFECTIVE SYMPTOMS; CORPUS CALLOSUM; EVOKED POTENTIALS, MOTOR; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; MOTOR CORTEX; NERVE NET; NEURAL INHIBITION; SEVERITY OF ILLNESS INDEX; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 41149177639     PISSN: 00333190     EISSN: None     Source Type: Journal    
DOI: 10.1159/000119737     Document Type: Article

References (69)

1. Nemiah JC, Sifneos PE: Psychosomatic illness: a problem in communication. Psychother Psychosom 1970;18:154-160.
2. Nemiah JC, Sifneos PE: Affect and fantasy in patients with psychosomatic disorders; in Hill OW (ed): Modern Trends in Psychosomatic Medicine. London, Butterworths, 1970, vol 2, pp 26-34.
3. Taylor GJ, Bagby RM, Parker JDA: Disorders of Affect Regulation: Alexithymia in Medical and Psychiatric Illness. Cambridge, Cambridge University Press, 1997.
4. Kauhanen J, Kaplan GA, Cohen RD, Salonen R, Salonen JT: Alexithymia may influence the diagnosis of coronary heart disease. Psychosom Med 1994;56:237-244.
5. Dewaraja R, Tanigawa T, Araki S, Nakata A, Kawamura N, Ago Y, Sasaki Y: Decreased cytotoxic lymphocyte counts in alexithymia. Psychother Psychosom 1997;66:83-86.
6. Porcelli P, Taylor GJ, Bagby RM, De Carne M: Alexithymia and functional gastrointestinal disorders. A comparison with inflammatory bowel disease. Psychother Psychosom 1999;68:263-269.
7. Bourke MP, Taylor GJ, Parker JD, Bagby RM: Alexithymia in women with anorexia nervosa. A preliminary investigation. Br J Psychiatry 1992;161:240-243.
8. Parker JD, Taylor GJ, Bagby RM, Acklin MW: Alexithymia in panic disorder and simple phobia: a comparative study. Am J Psychiatry 1993;150:1105-1107.
9. Marchesi C, Fonto S, Balista C, Cimmino C, Maggini C: Relationship between alexithymia and panic disorder: a longitudinal study to answer an open question. Psychother Psychosom 2005;74:56-60.
10. Parker JD, Wood LM, Bond BJ, Shaughnessy P: Alexithymia in young adulthood: a risk factor for pathological gambling. Psychother Psychosom 2005;74:51-55.
11. Grabe HJ, Ruhrmann S, Ettelt S, Muller A, Buhtz F, Hochrein A, Schulze-Rauschenbach S, Meyer K, Kraft S, Reck C, Pukrop R, Klosterkotter J, Falkai P, Maier W, Wagner M, John U, Freyberger HJ: Alexithymia in obsessive-compulsive disorder - results from a family study. Psychother Psychosom 2006;75:312-318.
12. Larsen JK, Brand N, Bermond B, Hijman R: Cognitive and emotional characteristics of alexithymia: a review of neurobiological studies. J Psychosom Res 2003;54:533-541.
13. Taylor GJ, Bagby RM: New trends in alexithymia research. Psychother Psychosom 2004;73:68-77.
14. Tabibnia G, Zaidel E: Alexithymia, interhemispheric transfer, and right hemispheric specialization: a critical review. Psychother Psychosom 2005;4:81-92.
15. Hoppe KD, Bogen JE: Alexithymia in twelve commissurotomized patients. Psychother Psychosom 1977;28:148-155.
16. Buchanan DC, Waterhouse GJ, West SC Jr: A proposed neurophysiological basis of alexithymia. Psychother Psychosom 1980;34:248-255.
17. TenHouten WD, Hoppe KD, Bogen JE, Walter DO: Alexithymia: an experimental study of cerebral commissurotomy patients and normal control subjects. Am J Psychiatry 1986;143:312-316.
18. Zeitlin SB, Lane RD, O'Leary DS, Schrift MJ: Interhemispheric transfer deficit and alexithymia. Am J Psychiatry 1989;46:1434-1439.
19. Parker JD, Keightley ML, Smith CT, Taylor GJ: Interhemispheric transfer deficit in alexithymia: an experimental study. Psychosom Med 1999;61:464-468.
20. Lumley MA, Sielky K: Alexithymia, gender, and hemispheric functioning. Compr Psychiatry 2000;41:352-359.
21. Dewaraja R, Sasaki Y: A left to right hemisphere callosal transfer deficit of nonlinguistic information in alexithymia. Psychother Psychosom 1990;54:201-207.
22. Grabe HJ, Moller B, Willert C, Spitzer C, Rizos T, Freyberger HJ: Interhemispheric transfer in alexithymia: a transcallosal inhibition study. Psychother Psychosom 2004;73:117-123.
23. Richter J, Moller B, Spitzer C, Letzel S, Bartols S, Barnow S, Willert C, Freyberger HJ, Grabe HJ: Transcallosal inhibition in patients with and without alexithymia. Neuropsychobiology 2006;53:101-107.
24. Barker AT, Freeston IL, Jalinous R, Merton PA, Morton HB: Magnetic stimulation of the human brain. J Physiol 1985;369:371.
25. Barker AT, Jalinous R, Freeston IL: Non-invasive magnetic stimulation of the human motor cortex. Lancet 1985;i:1106-1107.
26. Walsh V, Cowey A: Transcranial magnetic stimulation and cognitive neuroscience. Nat Rev Neurosci 2000;1:73-79.
27. Maeda F, Pascual-Leone A: Transcranial magnetic stimulation: studying motor neurophysiology of psychiatric disorders. Psychopharmacology 2003;168:259-276.
28. Daskalakis ZJ, Christensen BK, Chen R, Fitzgerald PB, Zipursky RB, Kapur S: Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation. Arch Gen Psychiatry 2002;59:347-354.
29. Fitzgerald PB, Brown TL, Daskalakis ZJ, deCastella A, Kulkarni J: A study of transcallosal inhibition in schizophrenia using transcranial magnetic stimulation. Schizophr Res 2002;56:199-209.
30. Fitzgerald PB, Brown TL, Daskalakis ZJ, Kulkarni J: A transcranial magnetic stimulation study of inhibitory deficits in the motor cortex in patients with schizophrenia. Psychiatry Res 2002;114:11-22.
31. Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD: Interhemispheric inhibition of the human motor cortex. J Physiol 1992;453:525-546.
32. Meyer BU, Roricht S, Grafin von Einsiedel H, Kruggel F, Weindl A: Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain 1995;118:429-440.
33. Woiciechowsky C, Vogel S, Meyer BU, Lehmann R: Neuropsychological and neurophysiological consequences of partial callosotomy. J Neurosurg Sci 1997;41:75-80.
34. Meyer BU, Roricht S, Woiciechowsky C: Topography of fibers in the human corpus callosum mediating interhemispheric inhibition between the motor cortices. Ann Neurol 1998;43:360-369.
35. Di Lazzaro V, Oliviero A, Profice P, Insola A, Mazzone P, Tonali P, Rothwell JC: Direct demonstration of interhemispheric inhibition of the human motor cortex produced by transcranial magnetic stimulation. Exp Brain Res 1999;124:520-524.
36. Bressi C, Taylor G, Parker J, Bressi S, Brambilla V, Aguglia E, Allegranti I, Bongiorno A, Giberti F, Bucca M, Todarello O, Callegari C, Vender S, Gala C, Invernizzi G: Cross validation of the factor structure of the 20-item Toronto Alexithymia Scale: an Italian multicenter study. J Psychosom Res 1996;41:551-559.
37. Bagby RM, Taylor GJ, Parker JD, Dickens SE: The development of the Toronto Structured Interview for Alexithymia: item selection, factor structure, reliability and concurrent validity. Psychother Psychosom 2006;75:25-39.
38. Picardi A, Toni A, Caroppo E: Stability of alexithymia and its relationships with the 'big five' factors, temperament, character, and attachment style. Psychother Psychosom 2005;74:371-378.
39. Salmaso D, Longoni AM: Problems in the assessment of hand preference. Cortex 1985;21:533-549.
40. Wassermann EM: Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalogr Clin Neurophysiol 1998;108:1-16.
41. Smith MJ, Keel JC, Greenberg BD, Adams LF, Schmidt PJ, Rubinow DA, Wassermann EM: Menstrual cycle effects on cortical excitability. Neurology 1999;53:2069-2072.
42. Rossini PM, Berardelli A, Deuschl G, Hallett M, Maertens de Noordhout AM, Paulus W, Pauri F: Applications of magnetic cortical stimulation. The International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol Suppl 1999;52:171-185.
43. Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, Dimitrijevic MR, Hallett M, Katayama Y, Lucking CH, et al: Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 1994;91:79-92.
44. Hanajima R, Ugawa Y, Machii K, Mochizuki H, Terao Y, Enomoto H, Furubayashi T, Shiio Y, Uesugi H, Kanazawa I: Interhemispheric facilitation of the hand motor area in humans. J Physiol 2001;531:849-859.
45. Meyer BU, Kuhn A, Röricht S: Influence of the direction of induced currents on callosally and corticospinally mediated electromyographic responses following magnetic motor cortex stimulation in man. J Physiol 1996;497:34-35.
46. Bertini M, De Gennaro L, Ferrara M, Curcio G, Romei V, Fratello F, Cristiani R, Pauri F, Rossini PM: Reduction of transcallosal inhibition upon awakening from REM sleep in humans as assessed by transcranial magnetic stimulation. Sleep 2004;27:875-882.
47. De Gennaro L, Ferrara M, Bertini M, Pauri F, Cristiani R, Curcio G, Romei V, Fratello F, Rossini PM: Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses. Neurosci Res 2003;46:219-227.
48. De Gennaro L, Cristiani R, Bertini M, Curcio G, Ferrara M, Fratello F, Romei V, Rossini PM: Handedness is mainly associated with an asymmetry of corticospinal excitability and not of transcallosal inhibition. Clin Neurophysiol 2004;115:1305-1312.
49. De Gennaro L, Bertini M, Pauri F, Cristiani R, Curcio G, Ferrara M, Rossini PM: Callosal effects of transcranial magnetic stimulation (TMS): the influence of gender and stimulus parameters. Neurosci Res 2004;48:129-137.
50. Kano M, Fukudo S, Gyoba J, Kamachi M, Tagawa M, Mochizuki H, Itoh M, Hongo M, Yanai K: Specific brain processing of facial expressions in people with alexithymia: an H2 15O-PET study. Brain 2003;26:1474-1484.
51. Oliveri M, Babiloni C, Filippi MM, Caltagirone C, Babiloni F, Cicinelli P, Traversa R, Palmieri MG, Rossini PM: Influence of the supplementary motor area on primary motor cortex excitability during movements triggered by neutral or emotionally unpleasant visual cues. Exp Brain Res 2003;149:214-221.
52. Spitzer C, Brandl S, Rose HJ, Nauck M, Freyberger HJ: Gender-specific association of alexithymia and norepinephrine/cortisol ratios. A preliminary report. J Psychosom Res 2005;59:73-76.
53. Henry JP, Haviland MG, Cummings MA, Anderson DL, Nelson JC, MacMurray JP, McGhee WH, Hubbard RW: Shared neuroendocrine patterns of post-traumatic stress disorder and alexithymia. Psychosom Med 1992;54:407-415.
54. Ham BJ, Lee MS, Lee YM, Kim MK, Choi MJ, Oh KS, Jung HY, Lyoo IK, Choi IG: Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia. Neuropsychobiology 2005;52:151-154.
55. Huber M, Herholz K, Habedank B, Thiel A, Muller-Kuppers M, Ebel H, Subic-Wrana C, Kohle K, Heiss WD: Different patterns of regional brain activation during emotional stimulation in alexithymics in comparison with normal controls. Psychother Psychosom Med Psychol 2002;52:469-478.
56. Lane RD, Reiman EM, Bradley MM, Lang PJ, Ahern GL, Davidson RJ, Schwartz GE: Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia 1997;35:1437-1444.
57. Berthoz S, Artiges E, Van De Moortele PF, Poline JB, Rouquette S, Consoli SM, Martinot JL: Effect of impaired recognition and expression of emotions on frontocingulate cortices: an fMRI study of men with alexithymia. Am J Psychiatry 2002;159:961-967.
58. Gündel H, Lòpez-Sala A, Ceballos-Baumann AO, Deus J, Cardoner N, Marten-Mittag B, Soriano-Mas C, Pujol J: Alexithymia correlates with the size of the right anterior cingulate. Psychosom Med 2004;66:132-140.
59. Mantani T, Okamoto Y, Shirao N, Okada G, Yamawaki S: Reduced activation of posterior cingulate cortex during imagery in subjects with high degrees of alexithymia: a functional magnetic resonance imaging study. Biol Psychiatry 2005;57:982-990.
60. Critchley HD, Mathias CJ, Josephs O, O'Doherty J, Zanini S, Dewar B-K, Cipolotti L, Shallice T, Dolan RJ: Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain 2003;126:2139-2152.
61. Neumann SA, Sollers JJ 3rd, Thayer JF, Waldstein SR: Alexithymia predicts attenuated autonomic reactivity, but prolonged recovery to anger recall in young women. Int J Psychophysiol 2004;53:183-195.
62. Infrasca R: Alexithymia, neurovegetative arousal and neuroticism. An experimental study. Psychother Psychosom 1997;66:276-280.
63. Wehmer F, Brejnak C, Lumley M, Stettner L: Alexithymia and physiological reactivity to emotion-provoking visual scenes. J Nerv Ment Dis 1995;183:351-357.
64. Martin JB, Pihl RO: Influence of alexithymic characteristics on physiological and subjective stress responses in normal individuals. Psychother Psychosom 1986;45:66-77.
65. Daskalakis ZJ, Christensen BK, Fitzgerald PB, Roshan L, Chen R: The mechanisms of interhemispheric inhibition in the human motor cortex. J Physiol 2002;543:317-326.
66. Chen R: Interactions between inhibitory and excitatory circuits in the human motor cortex. Exp Brain Res 2004;154:1-10.
67. Chowdhury SA, Matsunami KI: GABAB-related activity in processing of transcallosal response in cat motor cortex. J Neurosci Res 2002;68:489-495.
68. Lewis DA, Gonzalez-Burgos G: Pathophysiologically based treatment interventions in schizophrenia. Nat Med 2006;12:1016-1022.
69. Bajbouj M, Lisanby SH, Lang UE, Danker-Hopfe H, Heuser I, Neu P: Evidence for impaired cortical inhibition in patients with unipolar major depression. Biol Psychiatry 2006;59:395-400.