Effect of acute hepatic failure on epirubicin pharmacokinetics after intrahepatic arterial injection in rats

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 3, 2008, Pages 493-496

  Nagata, Masashi ^a,b   Matsuo, Yasuko ^a,b   Hidaka, Muneaki ^a,b   Kawano, Yohei ^b   Okumura, Manabu ^b   Tokunaga, Jin ^a   Takamura, Norito ^a   Arimori, Kazuhiko ^b  

^a KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b UNIVERSITY OF MIYAZAKI HOSPITAL   (Japan)

Author keywords

Epirubicin; Hepatic failure; Intrahepatic arterial injection; Intravenous injection; Pharmacokinetics; Rat

Indexed keywords

CARBON TETRACHLORIDE; EPIRUBICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG LIVER LEVEL; LIVER FAILURE; MALE; NONHUMAN; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; EPIRUBICIN; HEPATIC ARTERY; INJECTIONS, INTRA-ARTERIAL; INJECTIONS, INTRAVENOUS; LIVER; LIVER FAILURE, ACUTE; LIVER FUNCTION TESTS; MALE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 41149174102     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.493     Document Type: Article

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