The effect of adrenomedullin on rats exposed to lead

Journal of Applied Toxicology

Volumn 28, Issue 2, 2008, Pages 140-146

  Dogru, Mehmet Ilker ^a   Dogru, Arzu Kocagun ^a   Gul, Mehmet ^a   Esrefoglu, Mukaddes ^a   Yurekli, Muhittin ^a   Erdogan, Selim ^a   Ates, Burhan ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Adrenomedullin; Antioxidant enzymes; Histology; Lead; Lipid peroxidation; Oxidative stress; Pathology; Ultrastructural changes

Indexed keywords

ADRENOMEDULLIN; CATALASE; GLUTATHIONE PEROXIDASE; LEAD; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LEAD POISONING; LIVER INJURY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SCORING SYSTEM;

ADRENOMEDULLIN; ANIMALS; ANTIOXIDANTS; CATALASE; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE PEROXIDASE; INJECTIONS, INTRAPERITONEAL; LEAD; LEAD POISONING; LIPID PEROXIDATION; LIVER; MALONDIALDEHYDE; MICROSCOPY, ELECTRON, TRANSMISSION; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TIME FACTORS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 41149173222     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1259     Document Type: Article

References (28)

1. Buege AJ, Aust SD. 1978. Microsomal lipid peroxidation. Meth. Enzymol. 52: 302-310.
2. Cao YN, Kuwasako K, Kato J, Yanagita T, Tsuruda T, Kawano J, Nagoshi Y, Chen AF, Wada A, Suganuma T, Eto T, Kitamura K. 2005. Beyond vasodilation: The antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aorta. Biochem. Biophys. Res. Commun. 332: 866-872.
3. Chen L, Kis B, Busija DW, Yamashita H, Ueta Y. 2005. Adrenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro. Regul. Pept. 130: 27-34.
4. Daggett DA, Oberley TD, Nelson SA, Wright LS, Kornguth SE, Siegel FL. 1998. Effects of lead on rat kidney and liver: GST expression and oxidative stress. Toxicology 128: 191-206.
5. El-Sokkary GH, Abdel-Rahman GH, Kamel ES. 2005. Melatonin protects against lead-induced hepatic and renal toxicity in male rats. Toxicology 213: 25-33.
6. Eto T. 2001. A review of the biological properties and clinical implications of adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP), hypotensive and vasodilating peptides. Peptides 22: 1693-1711.
7. Flora SJS, Pande M, Mehta A. 2003. Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Chem. Biol. Interact. 145: 267-280.
8. Gurer H, Ercal N. 2000. Can antioxidants be beneficial in the treatment of lead poisoning? Free Radic. Biol. Med. 29: 927-945.
9. Gurer-Orhan H, Sabir HU, Ozgunes H. 2004. Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology 195: 147-154.
10. Hsu PC, Guo YL. 2002. Antioxidant nutrients and lead toxicity. Toxicology 180: 33-44.
11. Ichiki Y, Kitamura K, Kangawa K, Kawamoto M, Matsuo H, Eto T. 1994. Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma. FEBS Lett. 338: 6-10.
12. Jougasaki M, Burnett JC. 2000. Adrenomedullin: potential in physiology and pathophysiology. Life Sci. 66: 855-872.
13. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T. 1993. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 192: 553-560.
14. Lawrance RA, Burk RF. 1976. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71: 952-958.
15. Lowry O, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurements with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
16. Luck H. 1963. Methods of Enzymatic Analysis. Verlag Chemie, Academic Press: New York; 885-888.
17. Moreira EG, Rosa GJM, Barros SBM, Vassilieff VS, Vassilieff I. 2001. Antioxidant defense in rat brain regions after developmental lead exposure. Toxicology 169: 145-151.
18. Nakamura R, Kato J, Kitamura K, Onitsuka H, Imamura T, Cao Y, Marutsuka K, Asada Y, Kangawa K, Eto T. 2004. Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats. Circulation 110: 426-431.
19. Pande M, Flora SJS. 2002. Lead induced oxidative damage and its response to combined administration of α-lipoic acid and succimers in rats. Toxicology 177: 187-196.
20. Patra RC, Swamp D, Dwivedi SK. 2001. Antioxidant effects of α tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology 162: 81-88.
21. Saxena G, Pathak U, Flora SJS. 2005. Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats. Toxicology 214: 39-56.
22. Shalan MG, Mostafa MS, Hassouna MM, El-Nabi SEH, El-Refaie A. 2005. Amelioration of lead toxicity on rat liver with vitamin C and Silymarin supplements. Toxicology 206: 1-15.
23. Shimosawa T, Ogihara T, Matsui H, Asano T, Ando K, Fujita T. 2003. Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress. Hypertension 41: 1080-1085.
24. Sivaprasad R, Nagaraj M, Varalakshmi P. 2004. Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver. J. Nutr. Biochem. 15: 18-23.
25. Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34: 497-500.
26. Tandon SK, Singh S, Prasad S, Srivastava S. 2002. Reversal of lead-induced oxidative stress by chelating agent, antioxidant or their combination in the rat. Environ. Res. 90: 61-66.
27. Yoshimoto T, Fukai N, Sato R, Sugiyama T, Ozawa N, Schichiri M, Hirata Y. 2004. Antioxidant effect of adrenomedullin on angiotensin II-induced reactive oxygen species generation in vascular smooth muscle cells. Endocrinology 145: 3331-3337.
28. Zudaire E, Martinez A, Cuttitta F. 2003. Adrenomedullin and cancer. Regul. Pept. 112: 175-183.