Epidemiology, diagnosis and treatments of non-steroidal anti-inflammatory drug-induced enteropathy: A review of the literature

Gastroenterological Endoscopy

Volumn 50, Issue 2, 2008, Pages 189-198

  Koga, Hideki ^a   Matsumoto, Takayuki ^a   Iida, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AZAPROPAZONE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; INDOMETACIN; KANAMYCIN; MEFENAMIC ACID; METRONIDAZOLE; MISOPROSTOL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PHENYLBUTAZONE; PIROXICAM; ROFECOXIB; SALAZOSULFAPYRIDINE;

CAPSULE ENDOSCOPY; CLINICAL FEATURE; CLINICAL TRIAL; DIAPHRAGM INJURY; DOUBLE BALLOON ENTEROSCOPY; ENTEROPATHY; GASTROINTESTINAL TRACT SCINTISCANNING; HUMAN; INTESTINE RADIOGRAPHY; MEDICAL LITERATURE; PERMEABILITY; PREVALENCE; PROPHYLAXIS; REVIEW; SMALL INTESTINE MUCOSA; ULCER PERFORATION; UNSPECIFIED SIDE EFFECT;

EID: 41149167647     PISSN: 03871207     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Allison MC, Howatson AG, Torrance CJ et al. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992 ; 327 : 749-54.
2. Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am J Med 1998 ; 105 : 31-8.
3. Laine L, Connors LG, Reicin A et al. Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use. Gastroenterology 2003 ; 124 : 288-92.
4. Graham DY, Opekun AR, Willingham FF et al. Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 2005 ; 3 : 55-9.
5. Goldstein JL, Eisen GM, Lewis B et al. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 2005 ; 3 : 133-41.
6. Maiden L, Thjodleifsson B, Theodors A et al. A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy. Gastroenterology 2005 ; 128 : 1172-8.
7. Prog Dig Endosc 1986 ; 28 : 29-33.
8. Japanese source
9. Japanese source
10. Japanese source
11. Lang J, Price AB, Levi AJ et al. Diaphragm disease : pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs. J Clin Pathol 1988 ; 41 : 516-26.
12. Zhao B, Sanati S, Eltorky M. Diaphragm disease: complete small bowel obstruction after long-term nonsteroidal anti-inflammatory drugs use. Ann Diagn Pathol 2005 ; 9 : 169-73.
13. Going JJ, Canvin J, Sturrock R. Possible precursor of diaphragm disease in the small intestine. Lancet 1993 ; 341 : 638-9.
14. Matsumoto T, Nakamura S, Esaki M et al. Endoscopic features of chronic nonspecific multiple ulcers of the small intestine : comparison with nonsteroidal anti - inflammatory drug - induced enteropathy. Dig Dis Sci 2006 ; 51 : 1357-63.
15. Matsumoto T, Iida M, Matsui T et al. Non-specific multiple ulcers of the small intestine unrelated to non-steroidal anti-inflammatory drugs. J Clin Pathol 2204 ; 57 : 1145-50.
16. Kessler WF, Shires GT, Fahey TJ. Surgical complications of nonsteroidal anti-inflammatory drug-induced small bowel ulceration. J Am Coll Surg 1997 ; 185 : 250-4.
17. Langman MJ, Morgam L, Worrall A. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. Br Med J (Clin Res Ed) 1985 ; 290 : 347-9.
18. Lanas A, Serrano P, Bajador E et al. Evidence of aspirin use in both upper and lower gastrointestinal perforation. Gastroenterology 1997 ; 112 : 683-9.
19. Japanese source
20. Japanese source
21. Japanese source
22. Japanese source
23. Japanese source
24. Japanese source
25. Japanese source
26. Japanese source
27. Japanese source
28. Japanese source
29. Japanese source
30. Japanese source
31. Holt S, Rigoglioso V, Sidhu M et al. Nonsteroidal anti-inflammatory drugs and lower gastrointestinal bleeding. Dig Dis Sci 1993 ; 38 : 1619-23.
32. Lanas A, Sekar MC, Hirschowitz BI. Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal bleeding. Gastroenterology 1992 ; 103 : 862-9.
33. Japanese source
34. Japanese source
35. Japanese source
36. Japanese source
37. Hayashi Y, Yamamoto H, Kita H et al. Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy. World J Gastroenterol 2005 ; 11 : 4861-4.
38. Adebayo D, Bjarnason I. Is non-steroidal anti-inflammaory drug (NSAID) enteropathy clinically more important than NSAID gastropathy? Postgrad Med J 2006 ; 82 : 186-91.
39. Japanese source
40. Japanese source
41. Choi VM, Coates JE, Chooi J et al. Small bowel permeability : a variable effect of NSAIDS. Clin Invest Med 1995 ; 18 : 357-61.
42. Davies NM, Saleh JY, Skjodt NM. Detection and prevention of NSAID-induced enteropathy. J Pharm Pharm Sci 2000 ; 3 : 137-55.
43. Davies NM, Jamali F, Skeith KJ. Nonsteroidal anti-inflammatory drug (NSAID) -induced enteropathy and severe chronic anemia in a patient with rheumatoid arthritis. Arth Rheum 1996 ; 39 : 321-4.
44. Bjarnason I, Macpherson A. The changing gastrointestinal side effect of non-steroidal anti-inflammatory drugs. A new approach for the prevention of a new problem. Scand J Gastroenterol Suppl 1989 ; 163 : 56-64.
45. Gaya DR, Mackenzie JF. Fecal calprotectin : a bright future for assessing disease activity in Crohn's disease. Q J Med 2002 ; 95 : 557-5.
46. Tibble JA, Sigthorsson G, Foster R et al. High prevalence of NSAID enteropathy as shown by a simple faecal test. Gut 1999 ; 45 : 362-6.
47. Matsumoto T, Iida M, Kuroki F et al. Effects of diet on experimentally induced intestinal ulcers in rats : morphology and tissue leukotrienes. Gut 1994 ; 35 : 1058-63.
48. Kelly DA, Piasecki C, Anthony A et al. Focal reduction of villous blood flow in early indomethacin enteropathy : a dynamic vascular study in the rat. Gut 1998 ; 42 : 366-73.
49. Shimizu K, Koga H, Iida M et al. Microcirculatory changes in experimental mesenteric longitudinal ulcers of the small intestine in rats. Dig Dis Sci 2007 ; Epub ahead of print.
50. Somasundaram S, Sigthorsson G, Simpson RJ et al. Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Aliment Pharmacol Ther 2000 ; 14 : 639-50.
51. Yamada T, Deitch E, Specian RD et al. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 1993 ; 17 : 641-62.
52. Reuter BK, Davies NM, Wallace JL. Nonsteroidal anti-inflammatory drug enteropathy in rats : role of permeability, bacteria and enterohepatic circulation. Gastroenterology 1997 ; 112 : 109-17.
53. Koga H, Aoyagi K, Matsumoto T et al. Experimental enteropathy in athymic and euthymic rats : synergistic role of lipopolysaccharide and indomethacin. Am J Physiol Gastrointest Liver Physiol 1999 ; 276 : 576-82.
54. Bjarnason I, Smethurst P, Fenn CG et al. Misoprostol reduces indomethacin-induced changes in human small intestinal permeability. Dig Dis Sci 1989 ; 34 : 407-11.
55. Sigthorsson G, Simon T, Hoover M et al. COX-2 inhibition with refecoxib does not increase intestinal permeability in healthy subject : a double-blind crossover study comparing refecoxib with placebo and indomethacin. Gut 2000 ; 47 : 527-32.
56. Silverstein FE, Faich G, Goldstein JL et al. Gastrointestinal toxicity with celecoxib as NSAIDs for osteoarthritis and rheumatoid arthritis in the CLASS study. JAMA 2000 ; 284 : 1247-55.
57. Bjarnason I, Smethurst P, Price A et al. Metronidazole reduces intestinal inflammation and blood loss in NSAID-induced enteropathy. Gut 1992 ; 33 : 1204-8.
58. Bjarnason I, Zanelli G, Prouse P et al. Treatment of nonsteroidal anti-inflammatory drug induced enteropathy. Gut 1990 ; 31 : 777-80.
59. Kamata Y, Iwamoto M, Nara H et al. A case of rheumatoid arthritis with protein losing enteropathy induced by multiple diaphragmatic strictures of the small intestine : successful treatment by bougieing under double-balloon enteroscopy. Gut 2006 ; 55 : 1372.
60. Japanese source
61. Prog Dig Endosc 1999 ; 54 : 65-8.