Nucleolar targeting of proteins by the tandem array of basic amino acid stretches identified in the RNA polymerase I-associated factor PAF49

Biochemical and Biophysical Research Communications

Volumn 369, Issue 4, 2008, Pages 1017-1021

  Ushijima, Ryujiro ^a,b   Matsuyama, Toshifumi ^a   Nagata, Izumi ^b   Yamamoto, Kazuo ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Basic aminoacid stretch; Nucleolar localization; PAF49; RNA polymerase I

Indexed keywords

AMINO ACID; DNA DIRECTED RNA POLYMERASE; INTERFERON REGULATORY FACTOR 3; PROTEIN PAF49; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN TARGETING; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; AMINO ACIDS, BASIC; ANIMALS; CARRIER PROTEINS; CELL NUCLEOLUS; CELL NUCLEUS; DNA MUTATIONAL ANALYSIS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; POINT MUTATION; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE DELETION;

EID: 41149154275     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.138     Document Type: Article

References (30)

1. Raška I., Koberna K., Malínský J., Fidlerová H., and Mašata M. The nucleolus and transcription of ribosomal genes. Biol. Cell 96 (2004) 579-594
2. Lam Y.W., Trinkle-Mulcahy L., and Lamond A.I. The nucleolus. J. Cell. Sci. 118 (2005) 1335-1337
3. Reeder R.H., and Roeder R.G. Ribosomal RNA synthesis in isolated nuclei. J. Mol. Biol. 67 (1972) 433-441
4. Görlich D., and Mattaj I.W. Nucleocytoplasmic transport. Science 271 (1996) 1513-1518
5. Moss T., Langlois F., Gagnon-Kugler T., and Stefanovsky V. A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis. Cell Mol. Life Sci. 64 (2007) 29-49
6. Song C.Z., Hanada K., Yano K., Maeda Y., Yamamoto K., and Muramatsu M. High conservation of subunit composition of RNA polymerase I (A) between yeast and mouse and the molecular cloning of mouse RNA polymerase I 40-kDa subunit RPA40. J. Biol. Chem. 269 (1994) 26976-26981
7. Hanada K., Song C.Z., Yamamoto K., Yano K., Maeda Y., Yamaguchi K., and Muramatsu M. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. EMBO J. 15 (1996) 2217-2226
8. Yamamoto K., Yamamoto M., Hanada K., Nogi Y., Matsuyama T., and Muramatsu M. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Mol. Cell. Biol. 24 (2004) 6338-6349
9. Panov K.I., Panova T.B., Gadal O., Nishiyama K., Saito T., Russell J., and Zomerdijk J.C.B.M. RNA Polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. Mol. Cell. Biol. 24 (2004) 6338-6349
10. Obata Y., Yamamoto K., Miyazaki M., Shimotohno K., Kohno S., and Matsuyama T. Role of cyclophilin B in activation of interferon regulatory factor-3. J. Biol. Chem. 280 (2006) 18355-18360
11. Shu-Nu C., Lin C.H., and Lin A. An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22. FEBS Lett. 484 (2000) 22-28
12. Catez F., Erard M., Schaerer-Uthurralt N., Kindbeiter K., Madjar J.J., and Diaz J.J. Unique motif for nucleolar retention and nuclear export regulated by phosphorylation. Mol. Cell. Biol. 22 (2002) 1126-1139
13. Rowland R.R., and Yoo D. Nucleolar-cytoplasmic shuttling of PRRSV nucleocapsid protein: a simple case of molecular mimicry or the complex regulation by nuclear import, nucleolar localization and nuclear export signal sequences. Virus Res. 95 (2003) 23-33
14. Horke S., Reumann K., Schweizer M., Will H., and Heise T. Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA. J. Biol. Chem. 279 (2004) 26563-26570
15. Lipsius E., Walter K., Leicher T., Philippen W., Bisotti M.-A., and Kruppa J. Evolutionary conservation of nuclear and nucleolar targeting sequences in yeast ribosomal protein S6A. Biochem. Biophys. Res. Commun. 333 (2005) 1353-1360
16. Andersen J.S., Lam Y.W., Leung A.K.L., Ong S.-E., Lyon C.E., Lamond A.I., and Mann M. Nucleolar proteome dynamics. Nature 433 (2005) 77-83
17. Lange A., Mills R.E., Lange C.J., Stewart M., Devine S.E., and Corbett A.H. Classical nuclear localization signals: definition, function, and interaction with importin S. J. Biol. Chem. 282 (2007) 5101-5105
18. Hiscott J. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282 (2007) 15325-15329
19. Lin R., Heylbroeck C., Pitha P.M., and Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18 (1998) 2986-2996
20. Reich N.C. Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation. J. Interferon Cytokine Res. 22 (2002) 103-109
21. Boisvert F.-M., van Koningsbruggen S., Navascués J., and Lamond A.I. The multifunctional nucleolus. Nat. Rev. Mol. Cell. Biol. 8 (2007) 574-585
22. Shou W. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97 (1999) 233-244
23. Wong J.M., Kusdra L., and Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat. Cell Biol. 4 (2002) 731-736
24. Sherr C.J. Divorcing ARF and p53: an unsettled case. Nat. Rev. Cancer 6 (2006) 663-673
25. Chipuk J.E., and Green D.R. Dissecting p53-dependent apoptosis. Cell Death Differ. 13 (2006) 994-1002
26. Weber J.D., Taylor L.J., Roussel M.F., Sherr C.J., and Bar-Sagi D. Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1 (1999) 20-26
27. Lohrum M.A., Ashcroft M., Kubbutat M.H., and Vousden K.H. Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol. 2 (2000) 179-181
28. Kalderon D., Richardson W.D., Markham A.F., and Smith A.E. Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 311 (1984) 33-38
29. Rizos H., Darmanian A.P., Mann G.J., and Kefford R.F. Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Oncogene 19 (2000) 2978-2985
30. Ubersax J.A., and Ferrell Jr. J.E. Mechanisms of specificity in protein phosphorylation. Nat. Rev. Mol. Cell Biol. 8 (2007) 530-541