Electrophysiologic effects of systemic and locally infused epibatidine on locus coeruleus neurons

European Journal of Pharmacology

Volumn 584, Issue 1, 2008, Pages 93-99

  Ganesh, Arjunan ^a,b   Gonzalez Sulser, Alfredo ^a   Chaijale, Nayla ^a   Cucchiaro, Giovanni ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Analgesia; Dorsal raphe; Electrophysiology; Epibatidine; Locus coeruleus

Indexed keywords

EPIBATIDINE; MECAMYLAMINE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG DOSE COMPARISON; HISTOLOGY; LOCUS CERULEUS; MALE; NERVE CELL EXCITABILITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACTION POTENTIALS; ANALGESICS, NON-NARCOTIC; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, PARENTERAL; INJECTIONS, SUBCUTANEOUS; LOCUS COERULEUS; MALE; MECAMYLAMINE; NEURONS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PYRIDINES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; TIME FACTORS;

EID: 41149143508     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.01.034     Document Type: Article

References (23)

1. Akaoka H., Saunier C.F., Chergui K., Charlety P., Buda M., and Chouvet G. Combining in vivo volume-controlled pressure microejection with extracellular unit recording. J. Neurosci. Methods 42 (1992) 119-128
2. Aston-Jones G., Akaoka H., Charlety P., and Chouvet G. Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurons. J. Neurosci. 11 (1991) 760-769
3. Bitner R.S., Nikkel A.L., Curzon P., Arneric S.P., Bannon A.W., and Decker M.W. Role of the nucleus raphe magnus in antinociception produced by ABT-594: immediate early gene responses possibly linked to neuronal nicotinic acetylcholine receptors on serotonergic neurons. J. Neurosci. 18 (1998) 5426-5432
4. Boyce S., Webb J.K., Shepheard S.L., Russell M.G., Hill R.G., and Rupniak N.M. Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats. Pain 85 (2000) 443-450
5. Cucchiaro G., and Commons K.G. Alpha 4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission. Synapse 49 (2003) 195-205
6. Cucchiaro G., Chaijale N., and Commons K.G. The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine. J. Pharmacol. Exp. Ther. 313 (2005) 389-394
7. Cucchiaro G., Chaijale N., and Commons K.G. The locus coeruleus nucleus as a site of action of the antinociceptive and behavioral effects of the nicotinic receptor agonist, epibatidine. Neuropharmacology 50 (2006) 769-776
8. Curtis A.L., Bethea T., and Valentino R.J. Sexually dimorphic responses of the brain norepinephrine system to stress and corticotropin-releasing factor. Neuropsychopharmacology 31 (2006) 544-554
9. Engberg G., and Hajos M. Nicotine-induced activation of locus coeruleus neurons-an analysis of peripheral versus central induction. Naunyn Schmiedebergs Arch. Pharmacol. 349 (1994) 443-446
10. Hentschke H., Schwarz C., and Antkowiak B. Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor-mediated inhibition. Eur. J. Neurosci. 21 (2005) 93-102
11. Jacobs B.L., and Fornal C.A. 5-HT and motor control: a hypothesis. Trends Neurosci. 16 (1993) 346-352
12. Kaehler S.T., Singewald N., and Philippu A. Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity. Naunyn Schmiedebergs Arch. Pharmacol. 359 (1999) 386-393
13. Kim M.A., Lee H.S., Lee B.Y., and Waterhouse B.D. Reciprocal connections between subdivisions of the dorsal raphe and the nuclear core of the locus coeruleus in the rat. Brain Res. 1026 (2004) 56-67
14. Margalit D., and Segal M. A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus. Psychopharmacology (Berl) 62 (1979) 169-173
15. Nakahara D. Influence of nicotine on brain reward systems: study of intracranial self-stimulation. Ann. N.Y. Acad. Sci. 1025 (2004) 489-490
16. Nishikawa K., and MacIver M.B. Agent-selective effects of volatile anesthetics on GABAA receptor-mediated synaptic inhibition in hippocampal interneurons. Anesthesiology 94 (2001) 340-347
17. Proudfit H.K., and Clark F.M. The projections of locus coeruleus neurons to the spinal cord. Prog. Brain Res. 88 (1991) 123-141
18. Qiao J.T., and Dafny N. Dorsal raphe stimulation modulates nociceptive responses in thalamic parafascicular neurons via an ascending pathway: further studies on ascending pain modulation pathways. Pain 34 (1988) 65-74
19. Segal M. Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on responses to noxious stimuli. J. Physiol. 286 (1979) 401-415
20. Sirois J.E., Lei Q., Talley E.M., Lynch III C., and Bayliss D.A. The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics. J. Neurosci. 20 (2000) 6347-6354
21. Tung C.S., Ugedo L., Grenhoff J., Engberg G., and Svensson T.H. Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids. Synapse 4 (1989) 313-318
22. Usher M., Cohen J.D., Servan-Schreiber D., Rajkowski J., and Aston-Jones G. The role of locus coeruleus in the regulation of cognitive performance. Science 283 (1999) 549-554
23. Wang Q.P., and Nakai Y. The dorsal raphe: an important nucleus in pain modulation. Brain Res. Bull. 34 (1994) 575-585