Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian population

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 79, Issue 4, 2008, Pages 471-473

  Fontanella, M ^a   Rainero, I ^a   Gallone, S ^a   Rubino, E ^a   Fenoglio, P ^a   Valfre W ^a   Garbossa, D ^a   Benevello, C ^a   Ducati, A ^a   Pinessi, L ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTICLE; BRAIN ARTERY ANEURYSM; CLINICAL FEATURE; CONTROLLED STUDY; DNA MODIFICATION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; SUBARACHNOID HEMORRHAGE;

ADULT; AGED; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN-6; INTRACRANIAL ANEURYSM; ITALY; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); RISK FACTORS; SUBARACHNOID HEMORRHAGE;

EID: 41149142912     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2007.131565     Document Type: Article

References (25)

1. Menghini W, Brown RD, Sicks JD, et al. Incidence and prevalence of intracranial aneurysms and hemorrhage in Olmsted County, Minnesota, 1965 to 1995. Neurology 1998;51:405-11.
2. Iwamoto H, Kiyohara Y, Fujishima M, et al. Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study. Stroke 1999;30:1390-5.
3. Saveland H, Hillman J, Brandt L, et al. Overall outcome in aneurysmal subarachnoid hemorrhage. A prospective study from neurosurgical units in Sweden during a 1-year period. J Neurosurg 1992;76:729-34.
4. Ogilvy CS, Cheung AC, Mitha AP, et al. Outcomes for surgical and endovascular management of intracranial aneurysms using a comprehensive grading system. Neurosurgery 2006;59:1037-42.
5. Broderick JP, Viscoli CM, Brott T, et al. Major risk factors for aneurysmal subarachnoid hemorrhage in the young are modifiable. Stroke 2003;34:1375-81.
6. Ruigrok YM, Rinkel GJ, Wijmenga C. Genetics of intracranial aneurysms. Lancet Neurol 2005;4:179-89.
7. Nahed BV, Bydon M, Ozturk AK, et al. Genetics of intracranial aneurysms. Neurosurgery 2007;60:213-25.
8. Chyatte D, Bruno G, Desai S, et al. Inflammation and intracranial aneurysms. Neurosurgery 1999;45:1137-46.
9. Tulamo R, Frösen J, Junnikkala S, et al. Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurgery 2006;59:1069-76.
10. Jayaraman T, Berenstein V, Li X, et al. Tumor necrosis factor alpha is a key modulator of inflammation in cerebral aneurysms. Neurosurgery 2005;57:558-64.
11. Cacquevel M, Lebeurrier N, Chéenne S, et al. Cytokines in neuroinflammation and Alzheimer's disease. Curr Drug Targets 2004;5:529-34.
12. Aarli JA. Role of cytokines in neurological disorders. Curr Med Chem 2003;10:1931-7.
13. Greisenegger S, Endler G, Haering D, et al. The (-174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events. Thromb Res 2003;110:181-6.
14. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369-76.
15. Brull DJ, Montgomery HE, Sanders J, et al. Interleukin-6 gene -174 g>c and -572 g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 2001;21:1458-63.
16. Rivera-Chavez FA, Peters-Hybki DL, Barber RC, et al. Interleukin-6 promoter haplotypes and interleukin-6 cytokine responses. Shock 2003;20:218-23.
17. Morgan L, Cooper J, Montgomery H, et al. The interleukin-6 gene -174G>C and -572G>C promoter polymorphisms are related to cerebral aneurysms. J Neurol Neurosurg Psychiatry 2006;77:915-17.
18. Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 1980;6:1-9.
19. Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 1968;28:14-20.
20. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet 1975;7905:480-4.
21. Huang D, Zheng C, Giscombe R, et al. Polymorphism at -174 and in the 3′ flanking region of interleukin-6 (II-6) gene in patients with myasthenia gravis. J Neuroimmunol 1999;101:197-200.
22. Hwang IR, Hsu PI, Peterson LE, et al. Interleukin-6 genetic polymorphisms are not related to Helicobacter pylori-associated gastroduodenal diseases. Helicobacter 2003;8:142-8.
23. Bird TD, Jarvik GP, Wood NW. Genetic association studies: genes in search of diseases. Neurology 2001;57:1153-4.
24. Licastro F, Grimaldi LM, Bonafè M, et al. Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging 2003;24:921-6.
25. Capurso C, Solfrizzi V, D'Introno A, et al. Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe. Exp Gerontol 2004;39:1567-73.