Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 3: Importance of the indole orientation

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2399-2403

  Lu, Qing ^a   Chen, Zheng ^a   Perumattam, John ^a   Wang, Dan Xiong ^a   Liang, Weiling ^a   Xu, Yong jin ^a   Do, Steven ^a   Bonaga, Llorente ^a   Higaki, Jeffrey ^a   Dong, Hanmin ^a   Liclican, Albert ^a   Sideris, Steve ^a   Laney, Maureen ^a   Dugar, Sundeep ^a   Mavunkel, Babu ^a   Levy, Daniel E ^a  

^a SCIOS INC   (United States)

Author keywords

Calmodulin; Inhibitors; Kinase; Maleimides

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINE; FUNCTIONAL GROUP; INDOLE; INDOLYLMALEIMIDE DERIVATIVE; MALEIMIDE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN KINASE (CALCIUM,CALMODULIN); UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; BENZENE DERIVATIVES; BINDING SITES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DRUG DESIGN; ENZYME INHIBITORS; HYDROPHOBICITY; INDOLES; MALEIMIDES; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 41149139078     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.057     Document Type: Article

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