Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2277-2281

  Tomassi, Cyrille ^a   Van Nhien, Albert Nguyen ^a   Marco Contelles, José ^b   Balzarini, Jan ^c   Pannecouque, Christophe ^c   De Clercq, Erik ^c   Soriano, Elena ^d   Postel, Denis ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d CSIC   (Spain)

Author keywords

Aminonitrile; ATSAO; Computational study; CSIC reaction; NNRTI; TSAO

Indexed keywords

[2',5' BIS O (TERT BUTYLDIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL] 3' SPIRO 5'' (4'' AMINO 1'',2'' OXATHIOLE 2'',2'' DIOXIDE)NUCLEOSIDE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE; HIV-1; HIV-2; MODELS, CHEMICAL; REVERSE TRANSCRIPTASE INHIBITORS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 41149136849     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.010     Document Type: Article

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